Research Article

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07/03/2015
Bud development; Gossypium hirsutum; Reverse-transcription-polymerase chain reaction; Semi-quantitative expression

Gene sequences previously identified in Arabidopsis buds were used as references in order to estimate temporal and tissue expression in buds, leaves, stem, and root tissues in cotton plants. Buds were evaluated during 3 phases: 2-8, 10-12, and 14-20 mm. Primers were designed for the ARF6, ATFY, and SEUSS genes for use in semi-quantitative reverse ... more

V.G.L. Batista; M.P.N. Pinheiro; P.A.Melo Filho; R.C. Santos; L.M. Lima
05/20/2016
AMMI; GE interaction; GGE biplot; Gossypium hirsutum

Seed cotton yield is a trait governed by multiple genes that cause changes in the performance of genotypes depending on the cultivation environment. Breeding programs examine the genotype x environment interaction (GE) using precise statistical methods, such as AMMI (additive main effects and multiplicative interaction) and GGE biplot (genotype main effects + genotype x environment ... more

F.J.C. Farias; L.P. Carvalho; J.L.Silva Filho; P.E. Teodoro; F.J.C. Farias; L.P. Carvalho; J.L.Silva Filho; P.E. Teodoro
10/05/2017
Cotton Seed Yield; Gossypium hirsutum; Indirect selection

The cotton crop has notable importance for Brazilian and worldwide economy. Relationships knowledge among characters allows developing alternatives that increase the genetic progress with simultaneous selection of several traits. The use of correlation estimates for use in indirect selection helps the breeder in the selection of characters and facilitates progress ... more

M.C. Reis; D.B.O. Cardoso; E.G.Silva Júnior; B.C. Gomes; L.T.G. Pereira; D.A. Gomes; L.B. Sousa
02/25/2019
Adaptability; Computational Intelligence; Gossypium hirsutum; Stability

Cotton is the most widely utilized natural fiber in the world. Brazil is currently one of the world’s largest cotton producers. Cotton crops are cultivated in all regions of the country, especially in the Cerrado biome. Studies of genotype x environment (GxE) interactions evaluate the adaptability and stability of cotton genotypes. Adaptability and stability ... more

D.B.O. Cardoso; E.G.Silva Júnior; M.C. Reis; L.B. de Sousa; L.M.S. Falco; M.C. Mamede; B.Q.V. Machado; T.S. Paiva; C.P. Gundim; G.A. Alves
12/19/2016
3' Untranslated Regions; Animals; Cell differentiation; Cell proliferation; Cells, Cultured; Down-regulation; Gene Expression Regulation, Developmental; Microfilament Proteins; MicroRNAs; Muscle development; Muscle Proteins; Myoblasts; Swine

MicroRNAs (miRNAs) play important roles in the development and biochemical functions of skeletal muscles. However, targeting of miRNAs to structural genes involved in Z-discs have not been investigated. Here, we describe a highly expressed miRNA, miR-432, in pig embryonic skeletal muscle, which appeared to target myozenin1 (MYOZ1), a protein involved in the muscular sarcomere microstructure. ... more

R.M. Ren; H. Liu; S.H. Zhao; J.H. Cao
2/16/2017
Cell differentiation; Colorectal neoplasms; Down-regulation; Female; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lymphatic metastasis; male; Prognosis; Survival analysis

Kruppel-like factors (KLFs) are a group of transcriptional regulators that have recently been identified to exhibit tumor-suppressive function against various gastrointestinal cancers. The present study aims to investigate the expression patterns and prognostic value of KLF-4 in colorectal cancers (CRCs). KLF-4 levels in CRC tissues were examined via immunohistochemistry analysis, real-time ... more

D.H. Xiu; Y. Chen; L. Liu; H.S. Yang; G.F. Liu
2/23/2017
Apoptosis; Blotting, Western; Breast neoplasms; Cell Line, Tumor; Cell Movement; Cell proliferation; Cyclin-Dependent Kinase Inhibitor p21; DNA-Binding Proteins; Down-regulation; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; MCF-7 cells; MicroRNAs; Microscopy, Electron; Neoplasm Invasiveness; Neoplasm Metastasis; Reverse Transcriptase Polymerase Chain Reaction; Transcription factors

Breast cancer, which derives from the epithelium of the mammary glands, is one of the most common cancers diagnosed in women globally. To date, the authors of many studies have reported that the deregulation of microRNAs (miRNAs) plays a crucial role in the occurrence, development, and metastasis of tumors. Here, we discovered that miR-660-5p was upregulated in the breast cancer cell lines ... more

Y. Shen; Y.F. Ye; L.W. Ruan; L. Bao; M.W. Wu; Y. Zhou
3/08/2017
Adaptor Proteins, Signal Transducing; Adult; Aged; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell proliferation; Down-regulation; Female; Genes, Tumor Suppressor; Humans; KB Cells; male; MicroRNAs; Middle Aged; Monomeric GTP-Binding Proteins; Mouth Neoplasms; RNA, Messenger

Ras association domain family member 5 (RASSF5), a member of the Ras association domain family, induces cell apoptosis by phosphorylating FOXO3a, which triggers target gene BIM (pro-apoptotic factor) activation. MiR-214 is overexpressed in oral cancer tissue, indicating its possible involvement in oral cancer pathogenesis. Bioinformatics analysis has revealed a complimentary sequence between ... more

T.K. Li; K. Yin; Z. Chen; Y. Bao; S.X. Zhang
3/16/2017
Actins; Apoptosis; Cell proliferation; Cells, Cultured; Coculture Techniques; Down-regulation; Hepatic stellate cells; Hepatocyte growth factor; Humans; Mesenchymal stem cells; Paracrine Communication

We investigated the paracrine effects of bone marrow mesenchymal stem cells (BMSCs) on the proliferation, apoptosis, and alpha-actin-2 (ACTA2) expression of hepatic stellate cells (HSCs), and explored the possible mechanisms of hepatocyte growth factor (HGF). We established a co-culture system by culturing BMSCs on the upper layer and HSCs on the lower layer of a 6-well Transwell plate. Normal ... more

H.J. Cao; M.D. Wang; S.G. Li; L. Zhu; J.H. Zheng
3/16/2017
Adult; Aged; Down-regulation; Factor VIII; Female; Gene Expression Regulation, Neoplastic; GTPase-Activating Proteins; Humans; Lymphatic metastasis; male; Middle Aged; Neoplasm Grading; Neoplasm Invasiveness; Nuclear Proteins; Stomach neoplasms; Vascular Endothelial Growth Factor A

Association of signal-induced proliferation-associated 1 (SIPA) gene and protein expression with gastric cancer development was examined. SIPA1 mRNA and protein levels were determined by real-time quantitative polymerase chain reaction and western blot, respectively, in 40 gastric tumor and tumor-adjacent normal tissues. SIPA1, VEGF-A, and FVIII levels in 60 gastric tumor and 40 tumor-adjacent ... more

J.Y. Li; J.B. Wang; C.B. Liu; D.L. Ma; J.H. Ma

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