Research Article

Related GMR Articles

09/09/2015
Chronic obstructive pulmonary disease; Gene polymorphism; Meta-analysis; Vitamin D-binding protein

Gene polymorphism of vitamin D-binding protein (VDBP) correlates with chronic obstructive pulmonary disease (COPD), but the results remain inconclusive. We aimed to explore the association between VDBP gene polymorphism and COPD. We searched MEDLINE, Embase, Web of Science, and China National Knowledge Infrastructure for publications addressing the association between VDBP gene ... more

Y.L. Wang; H. Kong; W.P. Xie; H. Wang
12/21/2015
Chronic obstructive pulmonary disease; Hypoxia-inducible factor-1α; Single nucleotide polymorphisms

In the present study, we examined whether hypoxia-inducible factor-1α (HIF-1α) polymorphisms are associated with the susceptibility to chronic obstructive pulmonary disease (COPD). One hundred and twenty patients with COPD and 112 healthy controls were recruited from the Han population in Southern China. Polymerase chain reaction-restriction fragment length polymorphism was used to assess ... more

W.T. Wei; B. Li; M. Chen; H.R. Jia; H.X. Zhang
10/27/2015
Chronic obstructive pulmonary disease; Polymorphism; Proteinase-activated receptor-1

We conducted a case-control study to investigate the association between PAR1 gene polymorphisms and the development of chronic obstructive pulmonary disease (COPD). A total of 270 patients with COPD and 270 control subjects were consecutively recruited between March 2012 and March 2014. A polymerase chain reaction restriction fragment length polymorphism assay was used to assess ... more

C.M. Yun; X.Y. Sang
08/19/2016
Chronic obstructive pulmonary disease; Inflammatory response; Intercellular adhesion molecule-1; Interleukin-1b

Chronic obstructive pulmonary disease (COPD) is a devastating lung disorder characterized by sustained airway flow restriction that is not fully reversible. The precise pathogenic mechanisms are unknown, but it is clear that cigarette smoking and chronic inflammatory stimulation are the major causes of COPD. Lung inflammation associated with COPD involves multiple cytokines, aggregation ... more

Y.X. Wang; M.L. Ji; C.Y. Jiang; Z.B. Qian; Y.X. Wang; M.L. Ji; C.Y. Jiang; Z.B. Qian
04/26/2016
A1298C; C677T; Male infertility; Meta-analysis; MTHFR; Polymorphisms

Published studies on the association between the C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene and male infertility risk are controversial. To obtain a more precise evaluation, we performed a meta-analysis based on published case-control studies. We conducted an electronic search of PubMed, EMBASE, the Cochrane Library, the Web of Science ... more

Y. Yang; Y.Y. Luo; S. Wu; Y.D. Tang; X.D. Rao; L. Xiong; M. Tan; M.Z. Deng; H. Liu; Y. Yang; Y.Y. Luo; S. Wu; Y.D. Tang; X.D. Rao; L. Xiong; M. Tan; M.Z. Deng; H. Liu; Y. Yang; Y.Y. Luo; S. Wu; Y.D. Tang; X.D. Rao; L. Xiong; M. Tan; M.Z. Deng; H. Liu
04/25/2016
Meta-analysis; Methylation; Promoter; RASSF1A; Renal cell cancer

Epigenetic inactivation of Ras-associated domain family 1A (RASSF1A) by hyper-methylation of its promoter region has been identified in various cancers. However, the role of RASSF1A in renal cancer has neither been thoroughly investigated nor reviewed. In this study, we reviewed and performed a meta-analysis of 13 published studies reporting correlations between ... more

Y.Q. Huang; H. Guan; C.H. Liu; D.C. Liu; B. Xu; L. Jiang; Z.X. Lin; M. Chen; Y.Q. Huang; H. Guan; C.H. Liu; D.C. Liu; B. Xu; L. Jiang; Z.X. Lin; M. Chen; Y.Q. Huang; H. Guan; C.H. Liu; D.C. Liu; B. Xu; L. Jiang; Z.X. Lin; M. Chen
04/07/2016
A1298C; C677T; Lung cancer; Meta-analysis; MTHFR; Polymorphisms

Results from previous studies on the association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms C677T and A1298C and lung cancer have been conflicting. The aim of this meta-analysis was to clarify the effect of MTHFR polymorphisms on the risk of lung cancer. An electronic search of PubMed, EMBASE, the Cochrane library, and the China Knowledge Resource ... more

Y. Yang; L.J. Yang; M.Z. Deng; Y.Y. Luo; S. Wu; L. Xiong; D. Wang; Y. Liu; H. Liu; Y. Yang; L.J. Yang; M.Z. Deng; Y.Y. Luo; S. Wu; L. Xiong; D. Wang; Y. Liu; H. Liu; Y. Yang; L.J. Yang; M.Z. Deng; Y.Y. Luo; S. Wu; L. Xiong; D. Wang; Y. Liu; H. Liu
04/04/2016
135G/C polymorphism; Acute myeloid leukemia; Meta-analysis; RAD51

Numerous studies have evaluated the association between the 135G/C polymorphism in the RAD51 gene and risk of acute myeloid leukemia (AML), but the results have been inconsistent. The aim of this study is to precisely examine the association between the 135G/C polymorphism in the RAD51 gene and AML risk through a meta-analysis. PubMed, Google Scholar, and Web of Science databases were ... more

L. Wu; Z.G. Long; Z.S. Dai; L. Wu; Z.G. Long; Z.S. Dai; L. Wu; Z.G. Long; Z.S. Dai
04/04/2016
Breast cancer; Meta-analysis; MicroRNA-10b; Prognostic factor

Many microRNAs (miRNAs) exhibit altered expression levels in cancers, and they may be considered as valuable prognostic biomarkers for cancers. Here we aimed to summarize the recent advances in miR-10b involvement in human breast cancer and analyze the predicting role of miR-10b for survival. We searched, Embase, and Wanfang databases to identify studies on the prognostic role of miR-10b ... more

N. Wang; P. Chen; L.P. Huang; T.Z. Wang; N. Wang; P. Chen; L.P. Huang; T.Z. Wang; N. Wang; P. Chen; L.P. Huang; T.Z. Wang
04/04/2016
Coffee intake; CYP1A2; Ethnicity; Meta-analysis; rs762551 SNP

The association between the single nucleotide polymorphism rs762551 in the cytochrome P450 family 1, subfamily A2 gene (CYP1A2) and caffeine consumption remains controversial. We conducted a meta-analysis to clarify this potential association. Twelve studies were selected from articles retrieved from the and Google Scholar databases, and the data were analyzed to determine the ... more

S. Denden; B. Bouden; H. Khelil; J. Ben Chibani; M.H. Hamdaoui; S. Denden; B. Bouden; H. Khelil; J. Ben Chibani; M.H. Hamdaoui; S. Denden; B. Bouden; H. Khelil; J. Ben Chibani; M.H. Hamdaoui

Pages