Research Article

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Gout is the most common form of inflammatory arthritis affecting men, and current evidence suggests that genetic factors contribute to its progression. As a previous study identified that WD40 repeat protein 1 (WDR1) is associated with gout in populations of European descent, we sought to investigate its relationship with this disease in the Han Chinese population. We genotyped ... more

L.J. Liu; X.Y. Zhang; N. He; K. Liu; X.G. Shi; T. Feng; T.T. Geng; D.Y. Yuan; L.L. Kang; T.B. Jin; L.J. Liu; X.Y. Zhang; N. He; K. Liu; X.G. Shi; T. Feng; T.T. Geng; D.Y. Yuan; L.L. Kang; T.B. Jin; L.J. Liu; X.Y. Zhang; N. He; K. Liu; X.G. Shi; T. Feng; T.T. Geng; D.Y. Yuan; L.L. Kang; T.B. Jin
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ACLY gene; Beef cattle; Growth traits; High-resolution melting

ATP citrate lyase (ACLY) is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA, which is a key precursor of both fatty acid and mevalonate synthesis pathways. Genetic variation of the ACLY gene may influence multiple traits associated with animal production. Here, we identified three non-synonymous mutations in ACLY exons in five beef cattle ... more

M.N. Li; X. Guo; P.J. Bao; X.Y. Wu; X.Z. Ding; M. Chu; C.N. Liang; P. Yan; M.N. Li; X. Guo; P.J. Bao; X.Y. Wu; X.Z. Ding; M. Chu; C.N. Liang; P. Yan
04/28/2016
Nuclear factor kappa B; Repeated implantation failure; Single nucleotide polymorphism; SNP

Despite more than a century of intensive study, the mechanisms of successful pregnancy remain unclear. Recent research suggests that NF-κB (nuclear factor kappa B) plays an important role in embryo implantation. In the current study, we aimed to identify SNPs that contribute to genetic susceptibility for recurrent implantation failure (RIF). Thus, we examined the potential associations ... more

L. Luo; D.H. Li; X.P. Li; S.C. Zhang; C.F. Yan; J.F. Wu; Y.H. Qi; J. Zhao; L. Luo; D.H. Li; X.P. Li; S.C. Zhang; C.F. Yan; J.F. Wu; Y.H. Qi; J. Zhao; L. Luo; D.H. Li; X.P. Li; S.C. Zhang; C.F. Yan; J.F. Wu; Y.H. Qi; J. Zhao
04/26/2016
Acute rejection; Cytokines; Liver transplantation; Single nucleotide polymorphism

Acute rejection (AR) recurrence after liver transplantation (LT) is one of the major complications that leads to chronic graft dysfunction. It has been reported that the polymorphisms in some cytokine genes are associated with human liver allograft rejection. This study mainly investigated the associations between polymorphisms in the genes encoding interleukin-10 (IL10), ... more

X.X. Zhang; R.J. Bian; J. Wang; Q.Y. Zhang; X.X. Zhang; R.J. Bian; J. Wang; Q.Y. Zhang; X.X. Zhang; R.J. Bian; J. Wang; Q.Y. Zhang
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CD4 T cell; CD8 T cell; HIV; Single nucleotide polymorphism

Toll-like receptors (TLRs) are essential elements of the innate immune response to different infections including the infection with human immunodeficiency virus (HIV). Single nucleotide polymorphisms (SNPs) in TLRs such as TLR4 1063A/G and 1363C/T have been found to be associated with changes in CD4 count, viral load (VL), and disease progression during HIV infection. However, ... more

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05/23/2016
IL-13; IL-3; Rheumatoid arthritis; Single nucleotide polymorphism

The aim of this study was to examine the association between polymorphisms in the interleukin-3 and -13 (IL-3 and IL-13) genes and rheumatoid arthritis (RA). In this hospital-based case-control study, we analyzed the IL-3 rs2073506 G/A, IL-3 rs40401 C/T, and IL-13 rs1800925 C/T polymorphisms in 615 RA patients and 839 controls from a Chinese Han ... more

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Hepatocellular carcinoma; let-7; Single nucleotide polymorphism

Hepatocellular carcinoma (HCC) is a complex polygenic disease whose development is dependent on many genetic factors. The let-7 family, an important and widely studied microRNA family, has been shown to play an important role in the initiation and progression of HCC. In this study, we examined the possible associations between single-nucleotide polymorphisms in the promoter ... more

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Preeclampsia; rs7579169; Single nucleotide polymorphism

As a heterogeneous group of disorders in pregnancy, many genetic factors are involved in the development of preeclampsia. The single nucleotide polymorphism (SNP) rs7579169, located on chromosome 2q14.2, has been shown to be associated with pregnancy-induced hypertension in Europeans. In this study, we examined whether the SNP rs7579169 is associated with the susceptibility to ... more

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Hardy-Weinberg equilibrium; IL-19; Lupus nephritis; Single nucleotide polymorphism; Systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease that affects multiple organs and diminishes a patients’ quality of life. It has been suggested that interleukin 19 (IL-19) is engaged in intercellular signal transduction, which is related to the immune response and the local inflammatory reaction. Single nucleotide polymorphisms (SNPs) have been used to explore ... more

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Apoptosis; Autophagy; Beclin-1; Colorectal cancer; MicroRNA-30a; Prognosis

We investigated the associations between Beclin-1 and microRNA-30a (miR-30a) expression and the severity and treatment response in colorectal cancer (CRC). Our sample size consisted of 139 CRC patients who were treated with surgery alone. Immunohistochemistry was used to investigate the expression and prognostic significance of Beclin-1 in CRC, while the weak expression of Beclin-1 in ... more

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