Research Article

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04/04/2016
CD4 T cell; CD8 T cell; HIV; Single nucleotide polymorphism

Toll-like receptors (TLRs) are essential elements of the innate immune response to different infections including the infection with human immunodeficiency virus (HIV). Single nucleotide polymorphisms (SNPs) in TLRs such as TLR4 1063A/G and 1363C/T have been found to be associated with changes in CD4 count, viral load (VL), and disease progression during HIV infection. However, ... more

E.A. Said; F. Al-Yafei; F. Zadjali; M.S. Al-Balushi; S.S. Hasson; S.H. Al-Mahroqi; C.Y. Koh; K. Al-Naamani; J.Z. Al-Busaidi; M.A. Idris; A. Balkhair; A.A. Al-Jabri; E.A. Said; F. Al-Yafei; F. Zadjali; M.S. Al-Balushi; S.S. Hasson; S.H. Al-Mahroqi; C.Y. Koh; K. Al-Naamani; J.Z. Al-Busaidi; M.A. Idris; A. Balkhair; A.A. Al-Jabri; E.A. Said; F. Al-Yafei; F. Zadjali; M.S. Al-Balushi; S.S. Hasson; S.H. Al-Mahroqi; C.Y. Koh; K. Al-Naamani; J.Z. Al-Busaidi; M.A. Idris; A. Balkhair; A.A. Al-Jabri
02/05/2016
Adiponectin; Cytokines; Hemorrhagic shock; Inflammation; Mean arterial pressure; Serum

The aim of this study was to explore the relationship between adiponectin (ADPN) and hemorrhagic shock (HS) and the recovery after HS. This is significant for further understanding of the pathophysiological processes of HS and the development of better treatments. In total, 72 male C57BL/6 mice were assigned randomly to three groups: control, HS, and recovery (N = 24). The HS mouse model ... more

X. Gong; Y. Liu; S. Yao; J.F. Zheng; F. Wan; X.D. Xiang; X.P. Chai; X. Gong; Y. Liu; S. Yao; J.F. Zheng; F. Wan; X.D. Xiang; X.P. Chai
04/28/2016
Nuclear factor kappa B; Repeated implantation failure; Single nucleotide polymorphism; SNP

Despite more than a century of intensive study, the mechanisms of successful pregnancy remain unclear. Recent research suggests that NF-κB (nuclear factor kappa B) plays an important role in embryo implantation. In the current study, we aimed to identify SNPs that contribute to genetic susceptibility for recurrent implantation failure (RIF). Thus, we examined the potential associations ... more

L. Luo; D.H. Li; X.P. Li; S.C. Zhang; C.F. Yan; J.F. Wu; Y.H. Qi; J. Zhao; L. Luo; D.H. Li; X.P. Li; S.C. Zhang; C.F. Yan; J.F. Wu; Y.H. Qi; J. Zhao; L. Luo; D.H. Li; X.P. Li; S.C. Zhang; C.F. Yan; J.F. Wu; Y.H. Qi; J. Zhao
04/28/2016
Case-control study; Gout; Single nucleotide polymorphism; WDR1

Gout is the most common form of inflammatory arthritis affecting men, and current evidence suggests that genetic factors contribute to its progression. As a previous study identified that WD40 repeat protein 1 (WDR1) is associated with gout in populations of European descent, we sought to investigate its relationship with this disease in the Han Chinese population. We genotyped ... more

L.J. Liu; X.Y. Zhang; N. He; K. Liu; X.G. Shi; T. Feng; T.T. Geng; D.Y. Yuan; L.L. Kang; T.B. Jin; L.J. Liu; X.Y. Zhang; N. He; K. Liu; X.G. Shi; T. Feng; T.T. Geng; D.Y. Yuan; L.L. Kang; T.B. Jin; L.J. Liu; X.Y. Zhang; N. He; K. Liu; X.G. Shi; T. Feng; T.T. Geng; D.Y. Yuan; L.L. Kang; T.B. Jin
04/26/2016
Colorectal cancer; High-resolution melting; Mismatch repair gene; Single nucleotide polymorphism

Single nucleotide polymorphisms (SNPs) in mismatch repair genes, especially in the MLH1 gene, are closely associated with susceptibility to hereditary nonpolyposis colorectal cancer. However, few relevant findings are available regarding the association between sporadic colorectal cancer (SCRC) and SNPs of MLH1 in Chinese patients. Therefore, the present study aimed to ... more

H.X. Peng; X. Xu; R. Yang; Y.M. Chu; D.M. Yang; Y. Xu; F.L. Zhou; W.Z. Ma; X.J. Zhang; M. Guan; Z.H. Yang; Z.D. Jin; H.X. Peng; X. Xu; R. Yang; Y.M. Chu; D.M. Yang; Y. Xu; F.L. Zhou; W.Z. Ma; X.J. Zhang; M. Guan; Z.H. Yang; Z.D. Jin; H.X. Peng; X. Xu; R. Yang; Y.M. Chu; D.M. Yang; Y. Xu; F.L. Zhou; W.Z. Ma; X.J. Zhang; M. Guan; Z.H. Yang; Z.D. Jin
05/23/2016
IL-13; IL-3; Rheumatoid arthritis; Single nucleotide polymorphism

The aim of this study was to examine the association between polymorphisms in the interleukin-3 and -13 (IL-3 and IL-13) genes and rheumatoid arthritis (RA). In this hospital-based case-control study, we analyzed the IL-3 rs2073506 G/A, IL-3 rs40401 C/T, and IL-13 rs1800925 C/T polymorphisms in 615 RA patients and 839 controls from a Chinese Han ... more

M.J. Wang; X.D. Zhou; H. Zhang; R.P. Liu; M.J. Wang; X.D. Zhou; H. Zhang; R.P. Liu
05/13/2016
Hepatocellular carcinoma; let-7; Single nucleotide polymorphism

Hepatocellular carcinoma (HCC) is a complex polygenic disease whose development is dependent on many genetic factors. The let-7 family, an important and widely studied microRNA family, has been shown to play an important role in the initiation and progression of HCC. In this study, we examined the possible associations between single-nucleotide polymorphisms in the promoter ... more

Z.Y. Sui; J. Li; G.L. Cheng; S.F. Wang; Z.Y. Sui; J. Li; G.L. Cheng; S.F. Wang
05/09/2016
Preeclampsia; rs7579169; Single nucleotide polymorphism

As a heterogeneous group of disorders in pregnancy, many genetic factors are involved in the development of preeclampsia. The single nucleotide polymorphism (SNP) rs7579169, located on chromosome 2q14.2, has been shown to be associated with pregnancy-induced hypertension in Europeans. In this study, we examined whether the SNP rs7579169 is associated with the susceptibility to ... more

L.F. Guo; Z.H. Wang; Y.F. Wang; L.F. Guo; Z.H. Wang; Y.F. Wang
04/28/2016
Hardy-Weinberg equilibrium; IL-19; Lupus nephritis; Single nucleotide polymorphism; Systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease that affects multiple organs and diminishes a patients’ quality of life. It has been suggested that interleukin 19 (IL-19) is engaged in intercellular signal transduction, which is related to the immune response and the local inflammatory reaction. Single nucleotide polymorphisms (SNPs) have been used to explore ... more

J.R. Lin; H.H. Qin; Y. Wang; J. Liang; J.H. Xu; J.R. Lin; H.H. Qin; Y. Wang; J. Liang; J.H. Xu
07/29/2016
Cytokines; IL-18; IL-4; Non-Hodgkin’s lymphoma

Strong evidence indicates that tumor growth can be actively controlled by the immune system, and interleukins (ILs) are known to play an influential role in immune response regulation. Moreover, inflammatory cytokines are significantly involved in lymphoma pathogenesis. We aimed to investigate serum levels of IL-4 and IL-18 in aggressive non-Hodgkin’s lymphoma (A-NHL) patients and their ... more

H.O. Soydinc; N. Guney; M. Basaran; D. Duranyildiz; V. Yasasever; H.O. Soydinc; N. Guney; M. Basaran; D. Duranyildiz; V. Yasasever

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