Research Article

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06/11/2013
GNAQ; Han Chinese population; Polymorphism; Rheumatoid arthritis

Mice that lose Gαq from their immune system can spontaneously develop inflammatory arthritis. Gαq expression in the peripheral blood lymphocytes of rheumatoid arthritis (RA) patients is significantly decreased in comparison to that in healthy individuals, and reduced Gαq expression is closely correlated with RA disease activ­ity. These indicate that Gαq plays critical roles in the ... more

Y. Li; Y. Wang; Y. He; D. Wang; L. Deng; Y. Du; G. Shi
03/15/2013
IL-18; Polymorphism; Prostate cancer

Interleukin-18 (IL-18) has been implicated in a wide variety of cellular functions that affect the biological response to tumors. However, there is insufficient evidence to prove that IL-18 gene variants are associated with risk of prostate cancer. We examined a possible association between two promoter polymorphisms, -137G/C (rs187238) and -607C/A (rs1946518), in the IL-18 ... more

J.M. Liu; J.N. Liu; M.T. Wei; Y.Z. He; Y. Zhou; X.B. Song; B.W. Ying; J. Huang
02/07/2013
Polymorphism; Rheumatoid arthritis; Toll-like receptor

We investigated whether Toll-like receptor (TLR) polymorphisms confer susceptibility to rheumatoid arthritis and whether they influence clinical characteristics of rheumatoid arthritis. Studies were considered relevant for our meta-analysis if at least two comparisons of an issue were available. Eleven studies with 2078 patients with rheumatoid arthritis and 2581 controls were ... more

Y.H. Lee; S.C. Bae; G.G. Song
09/13/2012
GSTM1; Polymorphism; Primary open-angle glaucoma

Primary open-angle glaucoma (POAG) is characterized by loss of retinal ganglion cells, optic nerve damage and irreversible loss of visual field. Glaucoma is the second leading cause of blindness worldwide. It was estimated that in 2010 there were about 60.5 million glaucoma cases worldwide; among these patients, 4.5 million will become bilaterally blind. Glutathione S-transferases (GST) ... more

A.M. Barbosa; A.B. Frare; N.B. Costa; R.E. Silva; K.K.V.O. Moura
08/13/2012
Gastric cancer; Meta-analysis; NQO1 gene; Polymorphism; Risk

The association between the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene C609T polymorphism and gastric cancer has been widely evaluated, yet with conflicting results. Data were available from seven study populations involving 2600 subjects. Overall, comparison of alleles 609T and 609C indicated a significantly increased risk (46%) for gastric cancer (95% confidence interval (95 ... more

Y. Zhang; Z.T. Wang; J. Zhong
05/15/2012
5p15; Polymorphism; Prostate cancer

Recent evidence has suggested that single-nucleotide polymorphisms (SNPs) located at 5p15.33 contribute to susceptibilities for several cancer types, including prostate cancer. To determine whether SNP rs402710 in this region plays a role in prostate cancer, we analyzed these associations in a Chinese population; 251 prostate cancer patients and 273 control subjects were included in this ... more

Q. Ren; B. Xu; S.Q. Chen; Y. Yang; C.Y. Wang; Y.D. Wang; X.H. Wang; L.X. Hua; M. Chen
05/15/2012
Killer cell immunoglobulin-like receptor; Polymorphism; Pulmonary tuberculosis; susceptibility

Killer cell immunoglobulin-like receptors (KIRs) are involved in the pathogenesis of a variety of diseases. However, whether KIR polymorphism is associated with susceptibility to pulmonary tuberculosis was unknown. We examined a possible association of KIR polymorphism with susceptibility to pulmonary tuberculosis in Chinese Han. We analyzed 15 KIR genes in 109 pulmonary tuberculosis ... more

C. Lu; Y.J. Shen; Y.F. Deng; C.Y. Wang; G. Fan; Y.Q. Liu; S.M. Zhao; B.C. Zhang; Y.R. Zhao; Z.E. Wang; C.Z. Zhang; Z.M. Lu
04/27/2012
Polymorphism; PTPN22; Tuberculosis

The protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene, which encodes an intracellular lymphoid-specific phosphatase, is considered an important regulator of T-cell activation. We investigated a possible association between the PTPN22 C1858T (R620W) polymorphism and pulmonary tuberculosis in an Iranian population. Single nucleotide polymorphisms of PTPN22 C1858T (rs2476601) ... more

H.R. Kouhpayeh; M. Hashemi; S.A. Hashemi; A. Moazeni-Roodi; M. Naderi; B. Sharifi-Mood; M. Taheri; M. Mohammadi; S. Ghavami
03/14/2012
Diabetes mellitus; Hypertension; Polymorphism; RT-qPCR; VDR gene

RT-qPCR was used to analyze the vitamin D receptor (VDR) gene TaqI polymorphism in 100 Turkish patients with type 2 diabetes mellitus (T2DM) and hypertension compared with 100 healthy subjects, to determine whether VDR could be considered as one of the susceptibility genes for T2DM and hypertension. Genotyping was done with PCR, followed by melting curve analysis with specific fluorescent ... more

H.C. Vural; E. Maltas
01/09/2012
Chinese Hui population; Haplotype; Polymorphism; Rheumatoid arthritis; TIM-1

The T-cell immunoglobulin and mucin domain 1 (TIM-1) is known to be associated with susceptibility to rheumatoid arthritis (RA). We investigated the association of four single-nucleotide polymorphisms (SNPs) in the promoter region of the TIM-1 gene with susceptibility to RA in a Chinese Hui ethnic minority group. Using RFLP or sequence specific primer-PCR, 118 RA patients and 118 non- ... more

J.R. Xu; Y. Yang; X.M. Liu; J.Y. Sun; Y.J. Wang

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