Research Article

Related GMR Articles

12/18/2014
Biochemical recurrence; miR-146a; Polymorphism; Prostate cancer

Evidence has shown that miR-146a is involved in carcinogenesis and a common G/C variant (rs2910164) in the pre-miR-146a gene has been found to be associated with various cancers. We investigated the potential prognostic role of miR-146a polymorphism in prostate cancer after radical prostatectomy. Seventy-two southern Chinese with prostate cancer undergoing radical prostatectomy were ... more

M. Chen; Z.Y. Zhou; J.G. Chen; N. Tong; S.Q. Chen; Y. Yang; X.W. Zhang; H. Jiang; N. Liu; J. Liu; G.Z. Sha; W.D. Zhu; L.X. Hua; Z.J. Wang; B. Xu
12/04/2014
CYP1A1; CYP1A1m1; Glaucoma; Polymorphism; Primary open-angle glaucoma; Restriction fragment length polymorphism

The CYP1A1 gene is related to the generation of secondary metabolites that are capable of inducing DNA damage. The CYP1A1m1 polymorphism has been examined in many studies, and is located in a region near loci that have been linked to glaucoma, including the locus GLC1I. As a result, this polymorphism has been related to several diseases that are influenced by ... more

N.B. Costa; C.T.X. Silva; A.B. Frare; R.E. Silva; K.K.V.O. Moura
10/27/2014
Haplotype; Kazakh; Linkage disequilibrium; Metabolic syndrome; Polymorphism; PPARγ

We investigated the relationship between haplotype and linkage disequilibrium of the PPARγ gene polymorphisms rs3856806, rs12490265, rs1797912, and rs1175543 and metabolic syndrome (MS) in the Kazakh people of Xinjiang Province. For PPARγ, rs3856806, rs12490265, rs1797912, and rs1175543 genotypes were detected in 489 subjects (including 245 MS patients and 244 controls) using matrix- ... more

S.X. Guo; H. Guo; R.L. Ma; Y.S. Ding; J.Y. Zhang; J.M. Liu; M. Zhang; Q. Niu; N. Qiang; S.G. Li; C.N. Qi
04/29/2014
Essential hypertension; NPPB gene; Polymorphism; Pulse pressure

The aim of this study was to investigate the correlation between the natriuretic peptide precursor B (NPPB) gene single nucleotide polymorphism (SNP) c.-1298 G/T and pulse pressure (PP) of the Chinese Han population and the association between genotype and clinical indicators of hypertension. Peripheral blood was collected from 180 unrelated patients with hypertension and 540 healthy ... more

K. Zeng; X.D. Wu; H.D. Cai; Y.G. Gao; G. Li; Q.C. Liu; F. Gao; J.H. Chen; C.Z. Lin
01/17/2014
Chromosome abnormality; Chromosome rearrangement; Polymorphism; Recurrent pregnancy loss

The subsequent reproductive outcomes in couples with a history of recurrent pregnancy loss (RPL) associated with chromosome abnormalities or polymorphisms are generally not reported in China. Many RPL carrier couples have decided not to have children. The present study recorded the subsequent delivery, miscarriage, and unpregnancy outcomes of 113 RPL carrier couples and 226 non-carrier ... more

Y. Dong; L.L. Li; R.X. Wang; X.W. Yu; X. Yun; R.Z. Liu
04/17/2014
Catechol-O-methyltransferase (COMT); Polymorphism; Schizophrenia

Schizophrenia is a complex neuropsychiatric disorder strongly associated with dopamine dysregulation. Catechol-O-methyl-transferase (COMT) is a candidate gene for schizophrenia that encodes an enzyme involved in the metabolic inactivation of dopamine. The COMT Val158Met polymorphism has been associated with schizophrenia and has significant inter- and intra-ethnic variations. ... more

S. Al-Asmary; S. Kadasah; M. Arfin; M. Tariq; A. Al-Asmari
03/17/2014
Chinese muntjac; Microsatellite; Muntiacus reevesi; Polymorphism; Population genetics

Eight polymorphic microsatellite markers for Muntiacus reevesi were identified and characterized in this study. The number of alleles per locus ranged from 3 to 10 across 24-48 samples. The loci showed expected and observed heterozygosities of 0.577-0.876 and 0.387-0.933, respectively, with an average polymorphic information content value of 0.682. These markers should be a ... more

H. Wang; X. Luo; W.B. Shi; B.W. Zhang
03/17/2014
Association study; H-FABP; Polymorphism; PSMC1; Qinchuan cattle

Growth and carcass traits are economically important quality characteristics of beef cattle and are complex quantitative traits that are controlled by multiple genes. In this study, 2 candidate genes, H-FABP (encoding the heart fatty acid-binding protein) and PSMC1 (encoding the proteasome 26S subunit of ATPase 1) were investigated in Qinchuan beef cattle of China. PCR- ... more

W. Liang; H.L. Zhang; Y. Liu; B.C. Lu; X. Liu; Q. Li; Y. Cao
02/28/2014
Polymorphism; Porcine; Receptor function; TLR3

Toll-like receptor 3 (TLR3) recognizes double-stranded RNA, which is a molecular signature of viruses, and plays a pivotal role in host defense against viral invasion. Polymorphisms in the human TLR3 gene have been shown to affect the receptor function and to be associated with a variety of diseases, suggesting correlations between TLR3 polymorphisms and the disease resistance/ ... more

L. Wang; Y.C. Chen; D.J. Zhang; H.T. Li; D. Liu; X.Q. Yang
06/29/2015
Alzheimer’s disease; Apolipoprotein E; Meta-analysis; Polymorphism; PPARγ

We investigated whether Pro12Ala (C→G) and His447His (C→T) polymorphisms of the peroxisome proliferator-activated receptor gamma (PPARγ) gene are associated with susceptibility to Alzheimer’s disease (AD). We conducted a meta-analysis of the associations between the PPARγ Pro12Ala and His447His polymorphisms and AD in subjects. The meta-analysis was performed according to the ... more

Y.H. Lee; G.G. Song

Pages