Research Article

Related GMR Articles

07/14/2016
Hepatic cirrhosis; Hepatocellular carcinoma; Innate immunity; Toll-like receptor

Toll-like receptors (TLRs) can specifically identify pathogen-associated molecular patterns (PAMPs) by recognizing structural patterns in diverse microbial molecules, and can provide an effective defense against multiple microbial infectious. A variety of TLRs can be expressed on the surface of liver parenchymal as well as nonparenchymal cells. Kupffer cells are a type of hepatic ... more

L. Sun; J.J. Dai; W.F. Hu; J. Wang; L. Sun; J.J. Dai; W.F. Hu; J. Wang
06/24/2016
Crosstalk; Hepatitis B virus; Hepatocellular carcinoma; Network; Pathway

This study aims to identify significant pathways in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) based on the pathway network strategy. We proposed a pathway network where a protein-protein interaction (PPI) network was integrated with the crosstalk of pathways. Pathway data were first obtained from background PPI network, Reactome pathway database, and common genes ... more

L.M. Wen; W.Z. Wu; X.C. Peng; L.M. Wen; W.Z. Wu; X.C. Peng
06/20/2016
Hepatocellular carcinoma; Meta-analysis; Methylation; Pathogenesis; RUNX3

The aim of this study was to elucidate the role of RUNX3 promoter methylation in the pathogenesis of hepatocellular carcinoma (HCC) among Asians. For this purpose, we performed a comprehensive search of Chinese and English language scientific literature databases using stringent selection criteria; ultimately, we identified relevant studies that specifically assessed the ... more

W. Lu; Y. Liu; L.L. Liu; P.H. Zhuang; W. Lu; Y. Liu; L.L. Liu; P.H. Zhuang
05/13/2016
Hepatocellular carcinoma; let-7; Single nucleotide polymorphism

Hepatocellular carcinoma (HCC) is a complex polygenic disease whose development is dependent on many genetic factors. The let-7 family, an important and widely studied microRNA family, has been shown to play an important role in the initiation and progression of HCC. In this study, we examined the possible associations between single-nucleotide polymorphisms in the promoter ... more

Z.Y. Sui; J. Li; G.L. Cheng; S.F. Wang; Z.Y. Sui; J. Li; G.L. Cheng; S.F. Wang
05/09/2016
COX-2 -1195G>A (rs689466) polymorphism; COX-2 -765G>C (rs20417) polymorphism; Disease-free survival; Hepatocellular carcinoma; Independent influence factor

Cyclooxygenase-2 (COX-2) influences carcinogenesis through regulation of angiogenesis, apoptosis, cytokine expression, and immune response suppression. It has been well established that COX-2 is overexpressed in a variety of human cancers, such as hepatocellular carcinoma (HCC). In this study, we aimed to evaluate the association between COX-2 polymorphisms and prognosis of HCC. We ... more

R. Liang; X.X. Yan; Y. Lin; Q. Li; C.L. Yuan; Z.H. Liu; Y.Q. Li; R. Liang; X.X. Yan; Y. Lin; Q. Li; C.L. Yuan; Z.H. Liu; Y.Q. Li
04/27/2016
Espírito Santo-Brazil; Hereditary hemochromatosis; HFE gene; Iron metabolism disorders; Iron overload; Polymorphisms

Hereditary hemochromatosis (HH) is an autosomal recessive disorder that leads to progressive iron accumulation and may cause cirrhosis, hepatocellular carcinoma, diabetes, and heart failure. Most cases of HH have been linked to mutations in genes associated with iron homeostasis. There have been three major variants in the high Fe (HFE) gene associated with the disease: C282Y, ... more

L.N.R. Alves; E.V.W. Santos; E. Stur; A.M.A.Silva Conforti; I.D. Louro; L.N.R. Alves; E.V.W. Santos; E. Stur; A.M.A.Silva Conforti; I.D. Louro; L.N.R. Alves; E.V.W. Santos; E. Stur; A.M.A.Silva Conforti; I.D. Louro
04/26/2016
A1298C; C677T; Male infertility; Meta-analysis; MTHFR; Polymorphisms

Published studies on the association between the C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene and male infertility risk are controversial. To obtain a more precise evaluation, we performed a meta-analysis based on published case-control studies. We conducted an electronic search of PubMed, EMBASE, the Cochrane Library, the Web of Science ... more

Y. Yang; Y.Y. Luo; S. Wu; Y.D. Tang; X.D. Rao; L. Xiong; M. Tan; M.Z. Deng; H. Liu; Y. Yang; Y.Y. Luo; S. Wu; Y.D. Tang; X.D. Rao; L. Xiong; M. Tan; M.Z. Deng; H. Liu; Y. Yang; Y.Y. Luo; S. Wu; Y.D. Tang; X.D. Rao; L. Xiong; M. Tan; M.Z. Deng; H. Liu
04/07/2016
A1298C; C677T; Lung cancer; Meta-analysis; MTHFR; Polymorphisms

Results from previous studies on the association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms C677T and A1298C and lung cancer have been conflicting. The aim of this meta-analysis was to clarify the effect of MTHFR polymorphisms on the risk of lung cancer. An electronic search of PubMed, EMBASE, the Cochrane library, and the China Knowledge Resource ... more

Y. Yang; L.J. Yang; M.Z. Deng; Y.Y. Luo; S. Wu; L. Xiong; D. Wang; Y. Liu; H. Liu; Y. Yang; L.J. Yang; M.Z. Deng; Y.Y. Luo; S. Wu; L. Xiong; D. Wang; Y. Liu; H. Liu; Y. Yang; L.J. Yang; M.Z. Deng; Y.Y. Luo; S. Wu; L. Xiong; D. Wang; Y. Liu; H. Liu
08/10/2015
17a-Hydroxylase/17; 20-lyase deficiency; mutations; p. Thr101Ilefs*2; p. Thr306Ale

We determined whether a child with 17α-hydroxylase/17, 20-lyase deficiency possessed the sex-determining region (SRY) gene, and examined the mutations present in the CYP17A1 gene that led to 17α-hydroxylase/17, 20-lyase deficiency. In the child, karyotype analysis was performed and polymerase chain reaction analysis and electrophoretic techniques were used to identify the ... more

H. Xiao; H. Zhang; T. Li; D. Wu; L.T. Qin; T. Wang; B. Zhang; S.X. Liao
12/03/2015
CRTAP; LEPRE1; mutations; Osteogenesis imperfecta; PPIB

Osteogenesis imperfecta (OI) is a genetic disease characterized by bone deformities and fractures. Most cases are caused by autosomal dominant mutations in the type I collagen genes COL1A1 and COL1A2; however, an increasing number of recessive mutations in other genes have been reported. The LEPRE1, CRTAP, and PPIB genes encode proteins that ... more

C. Barbirato; M. Trancozo; M.G. Almeida; L.S. Almeida; T.O. Santos; J.C.G. Duarte; M.R.G.O. Rebouças; V. Sipolatti; V.R.R. Nunes; F. Paula

Pages