Research Article

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Cytokine-induced killer cells; EGFR tyrosine kinase inhibitor; Lung cancer; NKG2D ligands

We examined the effects and molecular mechanism of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib on NKG2D ligand expression in human lung adenocarcinoma A549 cells and the cytotoxicity of cytokine-induced killer cells. Flow cytometry was used to detect NKG2D ligand expression in A549 cells under effects of erlotinib and EGFR downstream molecules, ... more

J.Z. Mei; G.J. Liu; X.J. Zhang; J.Z. Zhao; R.T. Feng
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GSTM1; Lung cancer; Meta-analysis; Polymorphism

The relationship between glutathione S-transferase M1 (GSTM1) genetic polymorphisms and lung cancer has been reported previously. However, the results are not consistent. Therefore, to clarify the association between GSTM1 polymorphisms and lung cancer, we performed a meta-analysis based on published studies. We used the Revman 5.0 software to perform literature ... more

H. Liu; H.F. Ma; Y.K. Chen
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Gene polymorphism; Interleukin-6; Lung cancer; Meta-analysis

The results of previous case-control studies examining the relationship between the interleukin (IL)-6 gene -174G>C polymorphism and lung cancer are controversial. In this study, we evaluated the relationship between the IL-6 gene -174G>C polymorphism and lung cancer. We selected 5 case-control studies related to the IL-6 gene -174G>C polymorphism and lung cancer by searching the ... more

Y. Liu; X.L. Song; G.L. Zhang; A.M. Peng; P.F. Fu; P. Li; M. Tan; X. Li; M. Li; C.H. Wang
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Animals; Carcinosarcoma; Chromosome aberrations; Dogs; Female; genomic instability; Heterochromatin; Karyotype; Mammary Neoplasms, Animal; Ploidies

This study searched a rare and aggressive type of cancer in dogs and humans, the breast carcinosarcoma. Both clinical and pathological traits of mammary carcinosarcomas in dogs are similar to humans, such as infrequent occurrence, fast tumor growth, and unfavorable prognosis when compared to carcinomas. Other possible alterations include chromosomal abnormalities that can be useful for the ... more

C.S.D. Morais; P.R.A.M. Affonso; J.A. Bitencourt; A.A. Wenceslau
06/29/2017
Droughts; environment; genomic instability; Hybridization, Genetic; Models, Genetic; Plant breeding; Quantitative Trait, Heritable; Stress, Physiological; Zea mays

In several crops, the water deficit is perhaps the main limiting factor in the search for high yields. The objective of this study was to evaluate the phenotypic stability of maize hybrids in environments with and without water restriction using the analytical factor (AF) approach. We evaluated 171 maize hybrids in 14 environments, divided into environments with (A1, A2, A3, A4, A5, A6, and A7 ... more

A.O. Santos; J.J. Nuvunga; C.P. Silva; L.P.M. Pires; R.G. Von Pinho; L.J.M. Guimarães; M. Balestre
2017 Sep 27
Brazil; Edible Grain; environment; genomic instability; Genotype; Glycine max; Plant breeding; Quantitative Trait, Heritable; Selection, Genetic; Selective breeding

Biplot analysis has often been used to recommend genotypes from different crops in the presence of the genotype x environment interaction (GxE). The objective of this study was to verify the association between the AMMI and GGE biplot methods and to select soybean genotypes that simultaneously meet high grain yield and stability to the environments belonging to the Edaphoclimatic Region 402, ... more

E.U.Ramos Junior; R.L. Brogin; V.P.C. Godinho; F.J.E. Botelho; F.D. Tardin; P.E. Teodoro
2017 Sep 27
Gene-Environment Interaction; Genetic variation; genomic instability; Glycine max; Hypocotyl; Models, Genetic; Plant breeding; Plant Leaves; Quantitative Trait, Heritable; Selective breeding

In order to obtain the certificate of cultivar protection, it is necessary to prove its distinctiveness, homogeneity, and stability. Currently, there are 37 descriptors for differentiating soybeans cultivars. However, they are still not enough and, as a result, it is necessary to create, identify, and evaluate new descriptors. This study was aimed at evaluating the genotypic and environment ... more

M.V.A. Chaves; N.S. Silva; R.H.O. Silva; G.L. Jorge; I.C. Silveira; L.A. Medeiros; R.L. Hamawaki; O.T. Hamawaki; A.P.O. Nogueira; C.D.L. Hamawaki

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