Research Article

Related GMR Articles

06/17/2016
Cytochrome P450; Lung cancer; Meta-analysis; Polymorphism; Risk

The aim of this meta-analysis was to assess the association between a polymorphism (-3860 G > A) in the cytochrome P450 1A2 (CYP1A2) gene and lung cancer susceptibility. Relevant studies were retrieved from the PubMed and EMBase databases, and additionally evaluated for conformance with the inclusion criteria. The odds ratios (ORs) and their 95% confidence intervals (95%CIs) ... more

J. Ren; B.Z. He; T.S. Zhang; S.P. Lu; T. Yan; J. Ren; B.Z. He; T.S. Zhang; S.P. Lu; T. Yan
06/16/2016
Coronary artery disease; Interleukin 6; Polymorphism

To investigate the role of IL-6 polymorphism (-174G/C and -572C/G) in the development of coronary artery disease (CAD), CAD patients (224) and control subjects (260) were recruited between January 2012 and December 2014. Genotyping at IL-6 -174G/C and -572C/G was conducted via polymerase chain reaction coupled to restriction fragment length polymorphism. Results ... more

L. Mao; G.Y. Geng; W.J. Han; M.H. Zhao; L. Wu; H.L. Liu; L. Mao; G.Y. Geng; W.J. Han; M.H. Zhao; L. Wu; H.L. Liu
06/16/2016
Breast cancer; GSTP1; Meta-analysis; Polymorphism

Breast cancer (BC) is the most widespread cause of cancer-related deaths in women. Many published studies have assessed the association between the glutathione S-transferase P1 (GSTP1) rs1695 polymorphism and BC risk. However, the effect of the GSTP1 rs1695 polymorphism on BC risk has remained controversial. Therefore, this meta-analysis was conducted to obtain a ... more

M. Kuang; W. Xu; C.X. Cao; L.L. Shen; J. Chang; X.L. Zhang; J.F. Chen; C.J. Tang; M. Kuang; W. Xu; C.X. Cao; L.L. Shen; J. Chang; X.L. Zhang; J.F. Chen; C.J. Tang
06/15/2016
ApaI; End-stage renal disease; Polymorphism; Renal osteodystrophy; TaqI

Two single nucleotide polymorphisms (SNPs; TaqI and ApaI) in the vitamin D receptor (VDR) gene have been identified as risk factors for the progression of end-stage renal disease (ESRD). The purpose of our study was to confirm the reported association of these two SNPs with ESRD risk and progression of renal osteodystrophy in a Chinese Han population. A total of 452 ESRD ... more

L.Y. Wang; P. Zhang; H.F. Wang; Z.W. Qin; K.B. Wei; X.A. Lv; L.Y. Wang; P. Zhang; H.F. Wang; Z.W. Qin; K.B. Wei; X.A. Lv
06/10/2016
Coronary heart disease; Matrix metallopeptidase 1; Polymorphism; Type 2 diabetes mellitus

Matrix metallopeptidase 1 (MMP-1) has been reported to be involved in the coexistence of type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD). We sought to examine the association between the MMP-1 gene polymorphism and coexistence of T2DM and CHD in a Han Chinese population. We extracted genomic DNA from the peripheral blood of 794 subjects, including 378 patients ... more

Y.Z. Ma; Q.Y. Jiang; D.Q. Kong; Y.Z. Ma; Q.Y. Jiang; D.Q. Kong
06/10/2016
Meta-analysis; Polycystic ovary syndrome; Polymorphism; Tumor necrosis factor alpha

Previous studies have suggested that the tumor necrosis factor alpha (TNF-α) gene 308G/A polymorphism may be associated with polycystic ovary syndrome (PCOS) risk. However, this relationship is controversial. The present meta-analysis aimed to evaluate the correlation between the TNF-α308G/A polymorphism and susceptibility to PCOS. A systematic ... more

X.B. Liu; X.H. Deng; B. Zhou; L. Zhang; X.M. Niu; X.B. Liu; X.H. Deng; B. Zhou; L. Zhang; X.M. Niu
06/10/2016
IL-16; Polymorphism; Renal cell cancer

IL-16 plays an important role in affect the secretion of tumor-related inflammatory cytokines. We aimed to assess the role of interleukin-16 (IL-16) rs4778889 T/C and rs11556218 T/G polymorphisms in the occurrence of renal cell cancer (RCC). This study is composed of 274 RCC patients and 274 control subjects. Genotyping of polymorphisms was performed using polymerase chain ... more

S.X. Yang; F. Chen; J.W. Zhang; Z.Q. Sun; B.P. Chen; S.X. Yang; F. Chen; J.W. Zhang; Z.Q. Sun; B.P. Chen
06/03/2016
Asthma; BclI; ER22/23EK; N363S; NR3C1; Polymorphism; Tth111I

The aim of this study was to investigate the association between four single nucleotide polymorphisms in NR3C1 (Tth111I, BclI, ER22/23EK, and N363S), which encode the glucocorticoid receptor, and asthma susceptibility in patients from the Henan Province of China. Three hundred and twenty-eight patients with asthma and 60 healthy volunteers were recruited to ... more

Z. Cheng; L.L. Dai; Q. Liu; M. Liu; Q. Wang; P.F. Li; H. Wang; L.Q. Jia; L. An; Z. Cheng; L.L. Dai; Q. Liu; M. Liu; Q. Wang; P.F. Li; H. Wang; L.Q. Jia; L. An
06/03/2016
Interleukin-10; Meta-analysis; Pediatric asthma; Polymorphism

The results of previous epidemiological studies exploring the relationship between interleukin-10 (IL-10) promoter polymorphisms and susceptibility to pediatric asthma are not consistent. Therefore, we have performed a systematic review and meta-analysis to provide a more convincing conclusion. Odds ratios (OR) with their 95% confidence intervals (CIs) were used to evaluate the ... more

Z.Y. Huang; B.J. Cheng; Y. Wan; C. Zhou; Z.Y. Huang; B.J. Cheng; Y. Wan; C. Zhou
06/03/2016
Arg194Trp; Arg280His; Arg399Gln; Pancreatic cancer; Polymorphism; XRCC1

We conducted a case-control study to assess the role of the XRCC1 Arg399Gln, Arg280His, and Arg194Trp gene polymorphisms in pancreatic cancer susceptibility in a Chinese population. A total of 152 patients diagnosed with pancreatic cancer and 264 control subjects were enrolled in this study between March 2012 and October 2014. XRCC1 Arg399Gln, Arg280His, and Arg194Trp were genotyped ... more

L.J. Wang; H.T. Wang; X.X. Wang; L.J. Wang; H.T. Wang; X.X. Wang

Pages