Research Article

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06/10/2016
Chinese population; Gastric cancer; Polymorphism; XPG

We conducted a case-control study to investigate the role of three common single nucleotide polymorphisms (SNPs) in the xeroderma pigmentosum complementation group G (XPG) gene (rs2094258, rs751402 and rs17655) in the development of gastric cancer in a Chinese population. Between January 2012 and December 2014, samples from a total of 177 patients with gastric cancer and 237 ... more

Y.B. Feng; D.Q. Fan; J. Yu; Y.K. Bie; Y.B. Feng; D.Q. Fan; J. Yu; Y.K. Bie
05/20/2016
Breast cancer; Proliferation; Resveratrol; Tristetraprolin

Resveratrol is a natural compound that exhibits anticancer properties. Previous studies have proved that it can inhibit the proliferation of breast cancer cell lines and upregulate some cytokines such as cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). The initiation and progression of cancer are associated with the abnormal expression of multiple cytokines. ... more

C. Li; C. Tang; G. He; C. Li; C. Tang; G. He
05/13/2016
Association analysis; Breast cancer; Genetic variants; Haplotype; Hormone-related gene

Sex hormones play important roles in breast cancer (BC) development. This study investigated associations between BC risk and hormone-related gene variants in Chinese women. In a cohort of 336 patients with histopathologically confirmed BC and 390 age-matched controls, we genotyped seven single nucleotide polymorphisms (SNPs) in five hormone-related genes: estrogen receptor-α (ESR1 ... more

Z. Pan; Z. Fu; Q. Song; W. Cao; W. Cheng; X. Xu; Z. Pan; Z. Fu; Q. Song; W. Cao; W. Cheng; X. Xu
05/12/2016
Breast cancer; Keap1; Prognosis

Our objective was to explore the expression and clinical significance of Kelch-like epichlorohydrin-associated protein 1 (Keap1) in breast cancer tissue. Eighty-one breast cancer patients having undergone surgical treatment in our hospital between March 2002 and December 2008 were enrolled in this study. Normal tissue adjacent to tumors was used for the control samples. Diagnoses for all ... more

L. Zhang; W.P. Yang; L.Y. Wu; X. Zhu; C.Y. Wei; L. Zhang; W.P. Yang; L.Y. Wu; X. Zhu; C.Y. Wei
05/09/2016
Breast cancer; Folate; Genes; Genetic polymorphism; Thyroid cancer

Folate metabolism is essential for DNA synthesis and repair. Alterations in genes that participate in folate metabolism can be associated with several types of malignant neoplasms, including thyroid and breast cancer. In the present case-control study, we examined the association between methylenetetrahydrofolate reductase (MTHFR C677T, rs1801133) and methionine synthase (MTR ... more

T. Zara-Lopes; A.P.A. Gimenez-Martins; C.H.V. Nascimento-Filho; M.M.U. Castanhole-Nunes; A.L.S. Galbiatti-Dias; J.A. Padovani-Júnior; J.V. Maniglia; J.L.E. Francisco; E.C. Pavarino; E.M. Goloni-Bertollo; T. Zara-Lopes; A.P.A. Gimenez-Martins; C.H.V. Nascimento-Filho; M.M.U. Castanhole-Nunes; A.L.S. Galbiatti-Dias; J.A. Padovani-Júnior; J.V. Maniglia; J.L.E. Francisco; E.C. Pavarino; E.M. Goloni-Bertollo
06/16/2016
Breast cancer; GSTP1; Meta-analysis; Polymorphism

Breast cancer (BC) is the most widespread cause of cancer-related deaths in women. Many published studies have assessed the association between the glutathione S-transferase P1 (GSTP1) rs1695 polymorphism and BC risk. However, the effect of the GSTP1 rs1695 polymorphism on BC risk has remained controversial. Therefore, this meta-analysis was conducted to obtain a ... more

M. Kuang; W. Xu; C.X. Cao; L.L. Shen; J. Chang; X.L. Zhang; J.F. Chen; C.J. Tang; M. Kuang; W. Xu; C.X. Cao; L.L. Shen; J. Chang; X.L. Zhang; J.F. Chen; C.J. Tang
03/31/2014
NSCLC; SNPs; XPG; XRCC1; XRCC3

This study aimed to investigate the effects of single-nucleotide polymorphisms (SNPs) XRCC1 Arg194Trp, XRCC1 Arg280His, XRCC1 Arg399Gln, XRCC3 Thr241Met, XPG His104Asp, and XPG His46His in genes involved in the DNA-repair pathway on the outcomes of platinum-based chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). ... more

Z.Y. Jin; X.T. Zhao; L.N. Zhang; Y. Wang; W.T. Yue; S.F. Xu
01/24/2014
CSB; DNA repair-related genes; Prostate cancer; XPG

We aimed to investigate the association between genetic variants of the DNA repair genes XPG, CSB, XPC, CCNH, and MMS19L in the nucleotide excision repair (NER) pathway and risk of prostate cancer in a population in China. This study included 229 patients with newly diagnosed and histopathologically confirmed primary prostate cancer and 238 ... more

X.J. Zhang; P. Liu; F. Zhu
04/28/2016
16S rDNA; Pathogenicity island; Polymerase chain reaction; Polymorphism

Chromobacterium violaceum is a free-living Gram-negative bacillus usually found in the water and soil in tropical regions, which causes infections in humans. Chromobacteriosis is characterized by rapid dissemination and high mortality. The aim of this study was to detect the genetic variability among C. violaceum type strain ATCC 12472, and seven isolates from the ... more

A.C. Santini; J.T. Magalhães; J.C.M. Cascardo; R.X. Corrêa; A.C. Santini; J.T. Magalhães; J.C.M. Cascardo; R.X. Corrêa; A.C. Santini; J.T. Magalhães; J.C.M. Cascardo; R.X. Corrêa
04/28/2016
Coronary artery disease; IL-10-1082A/G; Polymorphism

We conducted a case-control study to investigate the association between IL-10-G1082A (rs1800896) polymorphism and the development of coronary artery disease (CAD) in the Chinese population. We recruited 295 CAD patients and 355 healthy controls from the Fifth Affiliated Hospital of Zhengzhou University between April 2012 and December 2014. Subjects were genotyped for IL-10 ... more

K. Liang; S.R. Dong; H. Peng; K. Liang; S.R. Dong; H. Peng; K. Liang; S.R. Dong; H. Peng

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