Research Article

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Sequence-related amplified polymorphism (SRAP) is a recently developed molecular marker technique that is stable, simple, reliable, and achieves moderate to high numbers of codominant markers. This study is the first to apply SRAP markers in a mammal, namely the Arctic fox. In order to investigate the genetic diversity of the Arctic fox and to provide a reference for use of its germplasm ... more

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The polymerase chain reaction-single-strand conforma­tion polymorphism technique was employed to measure mononucleo­tide diversity in the coding region of the leptin and leptin receptor genes in the Arctic fox. The relationships between specific genetic mutations and reproductive performance in Arctic foxes were determined to im­prove breeding strategies. We found that a leptin gene ... more

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Folate metabolism is essential for DNA synthesis and repair. Alterations in genes that participate in folate metabolism can be associated with several types of malignant neoplasms, including thyroid and breast cancer. In the present case-control study, we examined the association between methylenetetrahydrofolate reductase (MTHFR C677T, rs1801133) and methionine synthase (MTR ... more

T. Zara-Lopes; A.P.A. Gimenez-Martins; C.H.V. Nascimento-Filho; M.M.U. Castanhole-Nunes; A.L.S. Galbiatti-Dias; J.A. Padovani-Júnior; J.V. Maniglia; J.L.E. Francisco; E.C. Pavarino; E.M. Goloni-Bertollo; T. Zara-Lopes; A.P.A. Gimenez-Martins; C.H.V. Nascimento-Filho; M.M.U. Castanhole-Nunes; A.L.S. Galbiatti-Dias; J.A. Padovani-Júnior; J.V. Maniglia; J.L.E. Francisco; E.C. Pavarino; E.M. Goloni-Bertollo
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To understand genetic variability of the endangered aquatic herb Brasenia schreberi (Cabombaceae), we describe 31 microsatellite markers obtained using next-generation sequencing. A total of 24 individuals from the population of Jackson Lake, USA, were genotyped for each marker. Twenty-eight markers were polymorphic. The number of alleles per locus ranged from 1 to 9; the ... more

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