Research Article

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04/26/2016
ERCC1; ERCC2; Gastric cancer; Polymorphism; Treatment outcome

We conducted a prospective study to investigate whether ERCC1 rs11615 and rs3212986 and ERCC2 rs13181 and rs1799793 gene polymorphisms could serve as potential biomarkers for the prognosis of gastric cancer. Between January 2010 and December 2012, 246 patients with pathologically proven gastric cancer who were receiving platinum-based chemotherapy were recruited from the ... more

D.L. Zheng; G.D. Tang; Y.N. Chen; T. Zhang; M.B. Qin; D.L. Zheng; G.D. Tang; Y.N. Chen; T. Zhang; M.B. Qin; D.L. Zheng; G.D. Tang; Y.N. Chen; T. Zhang; M.B. Qin
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Bladder cancer; CYP1A2; Polymorphism; Risk

To date, no study has investigated the association between CYP1A2-163C/A polymorphism and bladder cancer risk in a Chinese population. Here, we extracted genomic DNA from peripheral white blood cells, and differentiated CYP1A2 alleles by polymerase chain reaction-based restriction fragment length polymorphism methods. Differences in genotype frequencies between the cases ... more

Y.L. Song; L. Wang; J.C. Ren; Z.H. Xu; Y.L. Song; L. Wang; J.C. Ren; Z.H. Xu; Y.L. Song; L. Wang; J.C. Ren; Z.H. Xu
04/28/2016
Esophageal cancer; Genetic variant; Polymorphism; Tumor necrosis factor-alpha
H. Zhao; H.W. Zhang; T. Zhang; X.M. Gu; H. Zhao; H.W. Zhang; T. Zhang; X.M. Gu; H. Zhao; H.W. Zhang; T. Zhang; X.M. Gu; H. Zhao; H.W. Zhang; T. Zhang; X.M. Gu; H. Zhao; H.W. Zhang; T. Zhang; X.M. Gu
07/14/2016
Gastric cancer; MicroRNA; Polymorphism; Review

MicroRNAs (miRNAs) are a class of small non-coding RNA molecules of about 22 nucleotides in length. miRNAs are highly conserved in both plants and animals, and function as gene regulators by binding to the 3'-untranslated region of target mRNAs for cleavage and/or translational repression. miRNA biogenesis, stability, and regulation of expression are strongly sequence dependent. Sequence ... more

B.W. Han; Z.H. Li; S.F. Liu; H.B. Han; S.J. Dong; H.J. Zou; R.F. Sun; J. Jia; B.W. Han; Z.H. Li; S.F. Liu; H.B. Han; S.J. Dong; H.J. Zou; R.F. Sun; J. Jia
06/24/2016
Chinese donkey; Microsatellite; Phylogenetic relationship; Polymorphism

To reveal the genetic diversity and phylogenetic relationships between Chinese donkey breeds, 415 individuals representing ten breeds were investigated using ten microsatellite markers. The observed number of alleles, mean effective number of alleles (NE), mean expected heterozygosity (HE), and polymorphic information content (PIC) of each breed and ... more

R.F. Zhang; W.M. Xie; T. Zhang; C.Z. Lei; R.F. Zhang; W.M. Xie; T. Zhang; C.Z. Lei
06/20/2016
Basigin gene; Esophageal cancer; miR-483-5p; Polymorphism

The aim of this study was to investigate the association between a functional variant of the basigin (BSG) gene, caused by a polymorphism (rs11473) at the miR-483-5p binding site, and the risk of esophageal squamous cell carcinoma (ESCC) in the Chinese population. The rs11473 polymorphism was genotyped in 624 esophageal cancer patients and 636 cancer-free age- and gender-matched ... more

H.Y. Li; Y.C. Liu; Y.H. Bai; M. Sun; L. Wang; X.B. Zhang; B. Cai; H.Y. Li; Y.C. Liu; Y.H. Bai; M. Sun; L. Wang; X.B. Zhang; B. Cai
06/20/2016
Cerebral infarction; Mononucleotide; Polymorphism; PPAR gamma

The variant of PPAR-g2 has been shown to promote the increase of carotid IMT in patients suffering from cerebral infarction and the Pro12Ala polymorphism in the peroxisome proliferator-activated receptorg2 (PPARg2) gene may be associated with cerebral infarction. However, due to the different genetic background, race, and regional variations of cerebral infarction ... more

X. Li; B.L. Zhang; X.G. Zhang; X.L. Su; X. Li; B.L. Zhang; X.G. Zhang; X.L. Su
06/20/2016
AMPD1; C34T; Essential hypertension; Malaysia; Polymorphism

The aim of this study was to determine whether C34T, a common polymorphism of the adenosine monophosphate deaminase 1 gene (AMPD1), is associated with essential hypertension (EH). We hypothesize that C34T is associated with the development of EH. A case-control design was used for this study. The DNA was extracted using a commercial kit from the whole blood of 200 patients with ... more

R. Nemati; J. Lu; V. Ramachandran; A. Etemad; M. Heidari; M.J. Yahya; R. Roozafzoon; P. Ismail; R. Nemati; J. Lu; V. Ramachandran; A. Etemad; M. Heidari; M.J. Yahya; R. Roozafzoon; P. Ismail
06/17/2016
ERCC5; Gastric cancer; Polymorphism

We investigate the role of ERCC5 gene polymorphisms (rs17655 and rs751402) in the development of gastric cancer in a Chinese population. A total of 142 gastric cancer patients whose diagnoses were confirmed by pathology, and 274 control subjects were recruited from Tangshan Gongren Hospital between March 2013 and March 2015. Genotyping of ERCC5 rs17655 and rs751402 ... more

B.W. Guo; L. Yang; R. Zhao; S.Z. Hao; B.W. Guo; L. Yang; R. Zhao; S.Z. Hao
06/16/2016
Coronary artery disease; Interleukin 6; Polymorphism

To investigate the role of IL-6 polymorphism (-174G/C and -572C/G) in the development of coronary artery disease (CAD), CAD patients (224) and control subjects (260) were recruited between January 2012 and December 2014. Genotyping at IL-6 -174G/C and -572C/G was conducted via polymerase chain reaction coupled to restriction fragment length polymorphism. Results ... more

L. Mao; G.Y. Geng; W.J. Han; M.H. Zhao; L. Wu; H.L. Liu; L. Mao; G.Y. Geng; W.J. Han; M.H. Zhao; L. Wu; H.L. Liu

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