Research Article

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04/28/2016
Hardy-Weinberg equilibrium; IL-19; Lupus nephritis; Single nucleotide polymorphism; Systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease that affects multiple organs and diminishes a patients’ quality of life. It has been suggested that interleukin 19 (IL-19) is engaged in intercellular signal transduction, which is related to the immune response and the local inflammatory reaction. Single nucleotide polymorphisms (SNPs) have been used to explore ... more

J.R. Lin; H.H. Qin; Y. Wang; J. Liang; J.H. Xu; J.R. Lin; H.H. Qin; Y. Wang; J. Liang; J.H. Xu
11/08/2011
MicroRNA; Non-invasive prenatal diagnosis; Preeclampsia

Preeclampsia continues to be a mortal disease of pregnant women throughout the world. Recently, geneticists, allied with obstetricians, have opened new frontiers. MicroRNAs (miRNAs) are members of a class of small, noncoding RNA molecules. They are critical posttranscriptional regulators of gene expression. We extracted circulating miRNA from maternal plasma and quantified mir-152 and mir ... more

T. Gunel; Y.G. Zeybek; P. Akçakaya; I. Kalelioglu; A. Benian; H. Ermis; K. Aydinli
07/15/2013
Leptin; Leptin receptor; Polymorphism; Preeclampsia

The aim of this study was to investigate the relationship between the leptin receptor (LEPR) polymorphism/serum leptin level and preeclampsia. The prevalence of a single nucleotide polymorphism in the LEPR gene exon 14 at -656 and the serum leptin concentrations in 97 preeclamptic pregnant mothers were compared to those of 110 healthy controls. The Lys656Asn genotype and ... more

S. Wang; F.Y. Qiao; L. Feng
08/13/2012
ACE; Insertion/deletion polymorphism; Preeclampsia

Preeclampsia affects 3-8% of pregnancies and is a major cause of maternal and perinatal morbidity and mortality worldwide. Inappropriate activation of the renin-angiotensin system may play a role in the development of preeclampsia. An insertion/deletion polymorphism in the angiotensin-converting enzyme gene (ACE-I/D) has been associated with differences in ACE activity. However, there are ... more

W.G. Zhong; Y. Wang; H. Zhu; X. Zhao
12/18/2014
Imprinted genes; PEG10; Preeclampsia; Trophoblastic cells

The aim of this study was to investigate the expression and significance of the imprinted gene PEG10 (paternally expressed gene 10) in preeclampsia placental tissue. Quantitative real-time reverse transcriptase polymerase chain reaction and immunohistochemistry to evaluate mRNA and protein expression and distribution of PEG10 in placental tissues obtained from 22 preeclampsia patients (8 ... more

X.Y. Liang; X. Chen; Y.Z. Jin; X.O. Chen; Q.Z. Chen
08/07/2014
Gestational hypertension; LIPC gene; Lipid metabolism; Preeclampsia; SNP

We examined the influence of the promoter polymorphisms -250G/A (rs2070895) and -514C/T (rs1800588) in the human hepatic lipase (LIPC) gene on dyslipidemia and hypertensive disorders complicating pregnancy (HDCP) in a Chinese population. Clinically defined HDCP patients (N = 321) and healthy pregnant women (N = 331) were recruited and genotyped using polymerase chain reaction- ... more

H. Lin; Z. Yin; X.Y. Yu; N. Lin; Y. Lin; J. Chen; Y.Z. Chen; K.P. Lu; H.K. Liu
01/17/2014
GSTM1; GSTT1; Preeclampsia

Preeclampsia is a pregnancy-specific disorder in humans and a major cause of maternal and neonatal morbidity and mortality. Increasing evidence suggests that oxidative stress plays an important role in the pathogenesis of preeclampsia. The aim of this study was to investigate the relationship between null alleles of the glutathione S-transferases (GST) M1 and T1 genes and the risk of ... more

A. Sandoval-Carrillo; M. Aguilar-Duran; F. Vázquez-Alaniz; F.X. Castellanos-Juárez; M. Barraza-Salas; E. Sierra-Campos; A. Téllez-Valencia; O. La Llave-León; J.M. Salas-Pacheco
06/18/2015
Gene expression; Partial least squares; Preeclampsia

Preeclampsia is major cause of maternal and fetal morbidity and mortality. Currently, the etiology of preeclampsia is unclear. In this study, we investigated differences in gene expression between preeclampsia patients and controls using partial least squares-based analysis, which is more suitable than routine analysis. Expression profile data were downloaded from the Gene Expression ... more

F. Jiang; Y. Yang; J. Li; W. Li; Y. Luo; Y. Li; H. Zhao; X. Wang; G. Yin; G. Wu
04/28/2016
Nuclear factor kappa B; Repeated implantation failure; Single nucleotide polymorphism; SNP

Despite more than a century of intensive study, the mechanisms of successful pregnancy remain unclear. Recent research suggests that NF-κB (nuclear factor kappa B) plays an important role in embryo implantation. In the current study, we aimed to identify SNPs that contribute to genetic susceptibility for recurrent implantation failure (RIF). Thus, we examined the potential associations ... more

L. Luo; D.H. Li; X.P. Li; S.C. Zhang; C.F. Yan; J.F. Wu; Y.H. Qi; J. Zhao; L. Luo; D.H. Li; X.P. Li; S.C. Zhang; C.F. Yan; J.F. Wu; Y.H. Qi; J. Zhao; L. Luo; D.H. Li; X.P. Li; S.C. Zhang; C.F. Yan; J.F. Wu; Y.H. Qi; J. Zhao
04/28/2016
Case-control study; Gout; Single nucleotide polymorphism; WDR1

Gout is the most common form of inflammatory arthritis affecting men, and current evidence suggests that genetic factors contribute to its progression. As a previous study identified that WD40 repeat protein 1 (WDR1) is associated with gout in populations of European descent, we sought to investigate its relationship with this disease in the Han Chinese population. We genotyped ... more

L.J. Liu; X.Y. Zhang; N. He; K. Liu; X.G. Shi; T. Feng; T.T. Geng; D.Y. Yuan; L.L. Kang; T.B. Jin; L.J. Liu; X.Y. Zhang; N. He; K. Liu; X.G. Shi; T. Feng; T.T. Geng; D.Y. Yuan; L.L. Kang; T.B. Jin; L.J. Liu; X.Y. Zhang; N. He; K. Liu; X.G. Shi; T. Feng; T.T. Geng; D.Y. Yuan; L.L. Kang; T.B. Jin

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