Research Article

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06/10/2016
Apoptosis; Chondrocytes; CREB phosphorylation; Hypoxia; Mitochondrial dysfunction

Chondrocytes, which are embedded within the growth-plate or the intervertebral disc, are sensitive to environmental stresses, such as inflammation and hypoxia. However, little is known about the molecular signaling pathways underlying hypoxia-induced mitochondrial dysfunction and apoptosis in chondrocytes. We first examined the apoptosis, caspase-3 activity, and apoptosis-associated ... more

Y.Y. Qiu; Y. Chen; T.H. Zeng; W.H. Guo; W.Y. Zhou; X.J. Yang; Y.Y. Qiu; Y. Chen; T.H. Zeng; W.H. Guo; W.Y. Zhou; X.J. Yang
06/03/2016
Henoch-Schönlein purpura nephritis; Matrix metalloproteinase-9; Single nucleotide polymorphisms

Henoch-Schönlein purpura nephritis (HSPN), the most serious long-term complication of Henoch-Schönlein purpura, is one of the most common renal diseases in children. Matrix metalloproteinase-9 (MMP-9) is implicated in the pathogenesis of renal diseases. Genomic DNA was isolated from the venous blood leukocytes of 220 unrelated patients with HSPN and 205 unrelated healthy individuals. To ... more

E.D. Xu; Y.F. Xiao; J.J. Wang; L. Dong; E.D. Xu; Y.F. Xiao; J.J. Wang; L. Dong
05/13/2016
Coronary artery disease; Matrix metalloproteinase-9; Polymorphism

We conducted a case-control study to investigate the role of one single nucleotide polymorphism of MMP-9 rs3918242 in the development of coronary artery disease. The rs3918242 was amplified with 435-bp DNA fragments using polymerase chain reaction coupled with restriction fragment length polymorphism. When compared with control subjects, patients with coronary artery disease had ... more

L.M. Qin; G.M. Qin; X.H. Shi; A.L. Wang; H. Zuo; L.M. Qin; G.M. Qin; X.H. Shi; A.L. Wang; H. Zuo
09/22/2015
Cartilage; Chondrocytes; Fibroblast growth factor 1; Osteoarthritis

Osteoarthritis (OA) is a degenerative disease of the systemic joint that involves multiple cytokines and growth factors. Fibroblast growth factor 1 (FGF-1) is increased in patients with rheumatic arthritis. The aim of this study was to determine whether the expression and secretion of FGF-1 differed in synovial tissue from patients with late stage OA from that in normal tissues. We selected ... more

R. Li; B. Wang; C.Q. He; Y.Q. Yang; H. Guo; Y. Chen; T.H. Du
12/17/2015
IL-6; miR-31; NF-κB; Peripheral blood mononuclear cells; TNF-α; Tuberculosis

We investigated the diagnostic values of microRNA-31 in peripheral blood mononuclear cells (PBMCs) for pediatric pulmonary tuberculosis in Chinese patients. Sixty-five children with TB were selected for this study, which was conducted at the Department of Infectious Diseases People’s Hospital of Laiwu City between December 2013 and December 2014. Sixty healthy children, selected in ... more

J.X. Wang; J. Xu; Y.F. Han; Y.B. Zhu; W.J. Zhang
10/24/2016
Bacterial killing; CD209a; Helicobacter pylori; LECT2; Macrophages; NF-κB

Helicobacter pylori employs unique methods to colonize the stomach, which induces chronic inflammation. It is also able to avoid eradication by macrophages and other immune cells. Leukocyte cell-derived chemotaxin 2 (LECT2), a multi-functional cytokine involved in many pathological conditions, has recently been shown to activate macrophages via the CD209a ... more

H.X. Shen; L. Li; Q. Chen; Y.Q. He; C.H. Yu; C.Q. Chu; X.J. Lu; J. Chen
11/03/2016
ICAM-1; IL-6; IL-8; Myocardial ischemia-reperfusion; NF-κB; Total peony glycoside

Early recovery of myocardial perfusion is beneficial for myocardial ischemia. However, ischemia-reperfusion (I/R) may exacerbate myocardial injury. Research shows that total peony glucoside (TPG) can inhibit ischemic myocardial cell apoptosis. However, whether it can ameliorate I/R injury remains poorly understood. This study explored the effect of TPG pretreatment ... more

L. Lu; P. Wei; Y. Cao; Q. Zhang; M. Liu; X.D. Liu; Z.L. Wang; P.Y. Zhang; L. Lu; P. Wei; Y. Cao; Q. Zhang; M. Liu; X.D. Liu; Z.L. Wang; P.Y. Zhang
11/03/2016
Liguistium wallichii; NF-κB; Renal carcinoma; UBE3A

Renal carcinoma accounts for a fifth of the morbidity among malignant tumors in China. Ubiquitin-protein ligase E3A (UBE3A) plays an important role in the occurrence and development of gene mutation-induced diseases. This study was designed to investigate the mechanism of Liguistium wallichii in treating renal carcinoma. Hematoxylin and eosin staining was ... more

J.S. Wu; P.M. Zhang; L.J. Sun; X.Z. Liu; J.S. Wu; P.M. Zhang; L.J. Sun; X.Z. Liu; J.S. Wu; P.M. Zhang; L.J. Sun; X.Z. Liu
10/24/2016
Antimicrobial peptides; Chromatography; Membrane permeabilization; Phytopathogenic fungi; Reactive oxygen species

Coffee, an agronomical crop of great economic importance, is also among the most commonly traded commodities in worldwide markets. Antimicrobial peptides, which play a role in plant defense, have been identified and isolated particularly from seeds. We isolated and immunolocalized Cc-LTP2, a new lipid transfer protein (LTP) from Coffea canephora ... more

G.C.V. Bard; U. Zottich; T.A.M. Souza; S.F.F. Ribeiro; G.B. Dias; S. Pireda; M. Da Cunha; R. Rodrigues; L.S. Pereira; O.L.T. Machado; A.O. Carvalho; V.M. Gomes; G.C.V. Bard; U. Zottich; T.A.M. Souza; S.F.F. Ribeiro; G.B. Dias; S. Pireda; M. Da Cunha; R. Rodrigues; L.S. Pereira; O.L.T. Machado; A.O. Carvalho; V.M. Gomes
11/03/2016
Cis-elements; Differential expression; Low temperature; Oryza sativa L.; Reactive oxygen species; Salinity

Different rice (Oryza sativa L.) genotypes were subjected to high salinity and low temperature (150 mM NaCl and 13°C, respectively) for 0, 6, 24, 48, or 72 h. We evaluated the simultaneous expression of the genes OsCATA, OsCATB, and OsCATC, correlated gene expression with enzyme activity, and verified the regulation of these ... more

I.L. Vighi; L.C. Benitez; M.Ndo Amaral; P.A. Auler; G.P. Moraes; G.S. Rodrigues; L.C. da Maia; L.S. Pinto; E.J.B. Braga; I.L. Vighi; L.C. Benitez; M.Ndo Amaral; P.A. Auler; G.P. Moraes; G.S. Rodrigues; L.C. da Maia; L.S. Pinto; E.J.B. Braga

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