Research Article

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05/09/2016
Preeclampsia; rs7579169; Single nucleotide polymorphism

As a heterogeneous group of disorders in pregnancy, many genetic factors are involved in the development of preeclampsia. The single nucleotide polymorphism (SNP) rs7579169, located on chromosome 2q14.2, has been shown to be associated with pregnancy-induced hypertension in Europeans. In this study, we examined whether the SNP rs7579169 is associated with the susceptibility to ... more

L.F. Guo; Z.H. Wang; Y.F. Wang; L.F. Guo; Z.H. Wang; Y.F. Wang
05/23/2016
Cytokine; Inflammatory; Regulatory; Systemic lupus erythematosus

To investigate the cytokine profile in serum and cerebrospinal fluid (CSF) from patients with systemic lupus erythematosus (SLE) and central nervous system infection, we measured interferon-g (IFN-g), interleukin-1b (IL-1b), IL-4, IL-6, IL-8, IL-10, and IL-17 levels in serum and CSF from 50 SLE patients and 38 matched controls. In patients with active compared to quiescent disease, serum ... more

Y. Yao; J.B. Wang; M.M. Xin; H. Li; B. Liu; L.L. Wang; L.Q. Wang; L. Zhao; Y. Yao; J.B. Wang; M.M. Xin; H. Li; B. Liu; L.L. Wang; L.Q. Wang; L. Zhao
04/28/2016
Nuclear factor kappa B; Repeated implantation failure; Single nucleotide polymorphism; SNP

Despite more than a century of intensive study, the mechanisms of successful pregnancy remain unclear. Recent research suggests that NF-κB (nuclear factor kappa B) plays an important role in embryo implantation. In the current study, we aimed to identify SNPs that contribute to genetic susceptibility for recurrent implantation failure (RIF). Thus, we examined the potential associations ... more

L. Luo; D.H. Li; X.P. Li; S.C. Zhang; C.F. Yan; J.F. Wu; Y.H. Qi; J. Zhao; L. Luo; D.H. Li; X.P. Li; S.C. Zhang; C.F. Yan; J.F. Wu; Y.H. Qi; J. Zhao; L. Luo; D.H. Li; X.P. Li; S.C. Zhang; C.F. Yan; J.F. Wu; Y.H. Qi; J. Zhao
04/28/2016
Case-control study; Gout; Single nucleotide polymorphism; WDR1

Gout is the most common form of inflammatory arthritis affecting men, and current evidence suggests that genetic factors contribute to its progression. As a previous study identified that WD40 repeat protein 1 (WDR1) is associated with gout in populations of European descent, we sought to investigate its relationship with this disease in the Han Chinese population. We genotyped ... more

L.J. Liu; X.Y. Zhang; N. He; K. Liu; X.G. Shi; T. Feng; T.T. Geng; D.Y. Yuan; L.L. Kang; T.B. Jin; L.J. Liu; X.Y. Zhang; N. He; K. Liu; X.G. Shi; T. Feng; T.T. Geng; D.Y. Yuan; L.L. Kang; T.B. Jin; L.J. Liu; X.Y. Zhang; N. He; K. Liu; X.G. Shi; T. Feng; T.T. Geng; D.Y. Yuan; L.L. Kang; T.B. Jin
04/26/2016
Colorectal cancer; High-resolution melting; Mismatch repair gene; Single nucleotide polymorphism

Single nucleotide polymorphisms (SNPs) in mismatch repair genes, especially in the MLH1 gene, are closely associated with susceptibility to hereditary nonpolyposis colorectal cancer. However, few relevant findings are available regarding the association between sporadic colorectal cancer (SCRC) and SNPs of MLH1 in Chinese patients. Therefore, the present study aimed to ... more

H.X. Peng; X. Xu; R. Yang; Y.M. Chu; D.M. Yang; Y. Xu; F.L. Zhou; W.Z. Ma; X.J. Zhang; M. Guan; Z.H. Yang; Z.D. Jin; H.X. Peng; X. Xu; R. Yang; Y.M. Chu; D.M. Yang; Y. Xu; F.L. Zhou; W.Z. Ma; X.J. Zhang; M. Guan; Z.H. Yang; Z.D. Jin; H.X. Peng; X. Xu; R. Yang; Y.M. Chu; D.M. Yang; Y. Xu; F.L. Zhou; W.Z. Ma; X.J. Zhang; M. Guan; Z.H. Yang; Z.D. Jin
04/26/2016
Acute rejection; Cytokines; Liver transplantation; Single nucleotide polymorphism

Acute rejection (AR) recurrence after liver transplantation (LT) is one of the major complications that leads to chronic graft dysfunction. It has been reported that the polymorphisms in some cytokine genes are associated with human liver allograft rejection. This study mainly investigated the associations between polymorphisms in the genes encoding interleukin-10 (IL10), ... more

X.X. Zhang; R.J. Bian; J. Wang; Q.Y. Zhang; X.X. Zhang; R.J. Bian; J. Wang; Q.Y. Zhang; X.X. Zhang; R.J. Bian; J. Wang; Q.Y. Zhang
04/04/2016
CD4 T cell; CD8 T cell; HIV; Single nucleotide polymorphism

Toll-like receptors (TLRs) are essential elements of the innate immune response to different infections including the infection with human immunodeficiency virus (HIV). Single nucleotide polymorphisms (SNPs) in TLRs such as TLR4 1063A/G and 1363C/T have been found to be associated with changes in CD4 count, viral load (VL), and disease progression during HIV infection. However, ... more

E.A. Said; F. Al-Yafei; F. Zadjali; M.S. Al-Balushi; S.S. Hasson; S.H. Al-Mahroqi; C.Y. Koh; K. Al-Naamani; J.Z. Al-Busaidi; M.A. Idris; A. Balkhair; A.A. Al-Jabri; E.A. Said; F. Al-Yafei; F. Zadjali; M.S. Al-Balushi; S.S. Hasson; S.H. Al-Mahroqi; C.Y. Koh; K. Al-Naamani; J.Z. Al-Busaidi; M.A. Idris; A. Balkhair; A.A. Al-Jabri; E.A. Said; F. Al-Yafei; F. Zadjali; M.S. Al-Balushi; S.S. Hasson; S.H. Al-Mahroqi; C.Y. Koh; K. Al-Naamani; J.Z. Al-Busaidi; M.A. Idris; A. Balkhair; A.A. Al-Jabri
05/23/2016
IL-13; IL-3; Rheumatoid arthritis; Single nucleotide polymorphism

The aim of this study was to examine the association between polymorphisms in the interleukin-3 and -13 (IL-3 and IL-13) genes and rheumatoid arthritis (RA). In this hospital-based case-control study, we analyzed the IL-3 rs2073506 G/A, IL-3 rs40401 C/T, and IL-13 rs1800925 C/T polymorphisms in 615 RA patients and 839 controls from a Chinese Han ... more

M.J. Wang; X.D. Zhou; H. Zhang; R.P. Liu; M.J. Wang; X.D. Zhou; H. Zhang; R.P. Liu
05/13/2016
Hepatocellular carcinoma; let-7; Single nucleotide polymorphism

Hepatocellular carcinoma (HCC) is a complex polygenic disease whose development is dependent on many genetic factors. The let-7 family, an important and widely studied microRNA family, has been shown to play an important role in the initiation and progression of HCC. In this study, we examined the possible associations between single-nucleotide polymorphisms in the promoter ... more

Z.Y. Sui; J. Li; G.L. Cheng; S.F. Wang; Z.Y. Sui; J. Li; G.L. Cheng; S.F. Wang
09/21/2015
Immunology; Lupus nephritis; Pathology; Reactivity index score

We investigated the effect of age on the expression of immune molecules [ANA, C4, double stranded DNA (dsDNA), CD16/32, CD19, CD3, and CD64], urine protein, and pathology in mice with chronic graft-versus-host disease (cGVHD) lupus nephritis (LN), and their relationship with reactivity index score. Mouse models of cGVHD LN were established, and mice were randomly divided into four aged-based ... more

X.F. Ma; F.L. Xu; L.F. Gao; Y.X. Wang; Z.B. Pan

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