Research Article

Related GMR Articles

Biomarker; Breast cancer; CCL-8; Prognosis; Serum

In this study, we investigated the correlation between serum chemokine (C-C motif) ligand 18 (CCL-18) and the prognosis as well as clinical characteristics of breast cancer. Blood samples from 207 breast cancer patients, 126 individuals with benign breast tumors, and 93 healthy women were collected. Serum CCL-18 expression was detected by enzyme-linked immunosorbent assay. Mann-Whitney’s ... more

J.H. Sun; N. Fan; Y. Zhang; J.H. Sun; N. Fan; Y. Zhang
Breast cancer; miR-99a; Prognosis; Serum

MicroRNA (miRNA) deregulation has been previously linked to the initiation and development of breast cancer. Although miR-99a is aberrantly expressed in many types of cancers, including breast cancer, the serum miR-99a expression level in breast cancer and its clinical significance remains unknown. Blood samples were obtained from 72 patients with breast cancer and 40 healthy volunteers ... more

J. Li; Z.J. Song; Y.Y. Wang; Y. Yin; Y. Liu; X. Nan; J. Li; Z.J. Song; Y.Y. Wang; Y. Yin; Y. Liu; X. Nan
Breast cancer; Estrogen metabolism; Genetic polymorphism; UGT1A1

Breast cancer is among the most common causes of cancer-related death in women worldwide. Previous studies have demonstrated an association between prolonged estrogen exposure and increased risk of breast cancer. Uridine 5'-diphospho-glucuronosyltransferase 1-1 (UGT1A1) plays a significant role in the detoxification of estrogens. Two major genetic polymorphisms have been identified in the ... more

J. Shi; L.H. Li; X.Y. Duan; Q. Liu; L.L. Sun; Y.T. Tian; J. Shi; L.H. Li; X.Y. Duan; Q. Liu; L.L. Sun; Y.T. Tian
Asthenospermia; Genetic polymorphisms; NSUN7 gene

\Previous studies have shown that genetic polymorphisms in exon7 of the NSUN7 gene can be used as an infertility marker in Iranian men with asthenospermia. However, there have been no equivalent studies in China. In the present study, we investigated the possible association between the genetic polymorphisms in exon7 of NSUN7 and asthenospermia in a Chinese Han population. We ... more

H.Y. Ren; R. Zhong; X.P. Ding; Z.Y. Chen; Y.L. Jing
Alcohol; Colorectal neoplasms; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2E1; Genetic polymorphisms; Smoking

Polymorphisms in genes encoding P450 cytochrome enzymes may increase the risk of sporadic colorectal cancer (SCRC). Here we investigated the association between SCRC and CYP2E1 (PstI) and CYP1A1 (MspI) polymorphisms in a case-control study. Moreover, we sought to determine any possible associations between this disease and the sociodemographic factors. ... more

M.A. Proença; G.M.M. Fernandes; A. Russo; R.B. Lelis; J.G. Netinho; G.S. Cunrath; A.E. Silva; E.M. Goloni-Bertollo; E.C. Pavarino
Genetic polymorphisms; Glutathione S-transferase; SA; Turabah

Glutathione-S-transferases (GST) are key phase II detoxifying enzymes that play critical roles in protection against products of oxidative stress and against electrophiles. Glutathione S-transferase mu (GST-M1) and theta (GST-T1) are isoforms of glutathione transferase enzymes that participate in the metabolism of a wide range of chemicals. Deletion variants ... more

A.A. Mansour; O.M. Saleh; T. Askar; A.M. Salim; A. Mergani
Chemokine receptor type 2-V64I; Chemokine receptor type 5-Δ32; Genetic polymorphisms; Mixed population; Northeastern Brazil

Chemokines are low-molecular weight proteins that play a key role in inflammatory processes. Genomic variations in chemokine receptors are associated with the susceptibility to various diseases. Polymorphisms in chemokine receptor type 5 (CCR5)-Δ32 and CCR2-V64I are related to human immunodeficiency virus infection resistance, which has led to genetic association studies ... more

H. Ferreira-Fernandes; A.C.C. Santos; F.J.N. Motta; R. Canalle; F.K.N. Yoshioka; R.R. Burbano; J.A. Rey; B.B. da Silva; G.R. Pinto
Chromosome 18; Fetus; Genetic polymorphisms; Short tandem repeat

We investigated the genetic polymorphisms of three short tandem repeat (STR) loci, D18S53, D18S59, and D18S488, on chromosome 18 in fetuses from a Chinese Tianjin Han population. Sixty-four villus samples and 374 amniotic fluid samples were collected from fetuses. Quantitative fluorescence polymerase chain reaction was performed to amplify the STR loci, followed by scanned electrophoresis ... more

X.Z. Li; J. Liu; Y.F. Shi; D. Ju; Y. Zhang; T.F. Yue; X.Z. Li; J. Liu; Y.F. Shi; D. Ju; Y. Zhang; T.F. Yue
Genetic polymorphisms; PCR; Scientometrics

Scientometrics is a quantitative evaluation of scientific and technological activities. The main objective is to point the number of methodologies used in scientific studies or even the structure of several research centers. This type of metric study belongs to the area of sociology of scientific knowledge. It covers quantitative analyzes of scientific activities ... more

A.M. Barbosa; K.S.F. De Silva; M.H. Lagares; D.A. Rodrigues; J.V.M. Martins; I.R. da Costa; K.K.V.O. Moura
Biochemical markers; Genetic polymorphisms; Oxidative stress; Schizophrenia

We evaluated the association of glutathione S-transferase polymorphisms (GSTT1 and GSTM1) and oxidative stress biomarkers in patients with schizophrenia. A total of 162 subjects were studied: 53 had schizophrenia (Total Study Group-TSG), and 109 without the disorder (Total Control Group-TCG). To analyze oxidative stress, TSG was distributed into ... more

L. Forner; T.N. Andreguetto; A.M. Lopes; P. Buosi; F.A. Borghi; I.S. Facincani; R. Fernandes-Ferreira; C.I.F. Oliveira-Brancati; E.A. de Almeida; A.A. Felício; D.P. Martins; G.M.A. Filho; D.R.S. Souza