Research Article

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10/24/2016
IFIH1; Meta-analysis; SLE; SLE clinical manifestations; SNPs

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder presenting heterogeneous clinical manifestations. A number of genes involved in SLE susceptibility are related to the type I interferon (IFN) pathway. IFN mediates innate immune responses and its increased levels contribute to the breakdown of peripheral tolerance. Interferon-induced helicase C ... more

deAzevêdo Silva; S.C. Lima; C. Addobbati; R. Moura; L.A.Cavalcanti Brandão; J.A.Trés Pancoto; E.A. Donadi; S. Crovella; P. Sandrin-Garcia
10/24/2016
-372C/G; -607A/C; Coronary artery disease; IL-18; Polymorphism

Coronary artery disease (CAD) has a high mortality rate in several countries. Interleukin (IL)-18 has been previously correlated with atherosclerotic plaque rupture. In this case-control study, the relationship between -607A/C and -372C/G promoter polymorphisms in IL-18 and risk of CAD development was investigated. A total of 326 CAD patients were ... more

J.B. Ma; L. Chen; B. Gao; J. Xu
10/24/2016
Biomarker; Env; Gag; HIV; Molecular epidemiology; Pol

HIV genotyping has led to conflicting results between laboratories. Therefore, identifying the most accurate gene combinations to sequence remains a priority. Datasets of Chinese HIV subtypes based on several markers and deposited in PubMed, Metstr, CNKI, and VIP databases between 2000 and 2015 were studied. In total, 9177 cases of amplification-positive samples ... more

L. Ren; H.W. Wang; Y. Xu; Y. Feng; H.F. Zhang; K.H. Wang
10/24/2016
ELOVL4 gene; PRPH2 gene; Stargardt disease

Stargardt disease (STGD) is an inherited genetic eye condition involving bilateral macular dystrophy leading to progressive central vision loss. It is the most common form of autosomal recessive juvenile macular dystrophy. In this study, ELOVL4 and PRPH2 genes were analyzed in 30 STGD probands for genetic variations using next-generation ... more

H. Bardak; M. Gunay; Y. Erçalık; Y. Bardak; H. Ozbas; O. Bagci; A. Ayata; M. Sönmez; C. Alagöz
10/24/2016
Bacterial killing; CD209a; Helicobacter pylori; LECT2; Macrophages; NF-κB

Helicobacter pylori employs unique methods to colonize the stomach, which induces chronic inflammation. It is also able to avoid eradication by macrophages and other immune cells. Leukocyte cell-derived chemotaxin 2 (LECT2), a multi-functional cytokine involved in many pathological conditions, has recently been shown to activate macrophages via the CD209a ... more

H.X. Shen; L. Li; Q. Chen; Y.Q. He; C.H. Yu; C.Q. Chu; X.J. Lu; J. Chen
11/13/2015
MyD88; Myeloid differentiation factor 88; Non-small cell lung carcinoma

We studied the expression level of myeloid differentiation factor 88 (MyD88) in non-small cell lung carcinoma (NSCLC) and normal paracancerous tissues, to determine its relationship with clinical pathological characteristics and prognosis. In total, 82 NSCLC patients who had received surgical treatment in our hospital between September 2008 and December 2013 were selected for this study. ... more

J. Zhu; Q. Li; J. He; K. Ma
10/29/2015
Blood test; Leptin; Meta-analysis; Non-small cell lung carcinoma; Serum levels; Standardized mean differences

In this study, we analyzed the association between serum leptin levels and non-small cell lung carcinoma (NSCLC). By examining English and Chinese databases, we identified potential relevant studies for statistical analysis. Human-associated case-control studies evaluating the association between serum leptin levels and NSCLC according to the random-effect model were retrieved and ... more

J. Du; J.C. Han; Y.J. Zhang; G.B. Qi; Y. Zhang; H.B. Li
06/03/2016
Clinical outcome; GSTP1 Ile105Val; Non-small cell lung carcinoma; XRCC1 Arg194Trp; XRCC1 Arg399Gln

Glutathione S-transferase P1 (GSTP1) and X-ray repair cross-complementing group 1 (XRCC1) genetic variations may in­fluence the efficacy of chemotherapy in various cancers. We investi­gated the possible roles of GSTP1 Ile105Val and XRCC1 Arg194Trp, and Arg399Gln gene polymorphisms in the prognosis of advanced non-small cell lung carcinoma ( ... more

L. Bu; L.B. Zhang; X. Mao; P. Wang; L. Bu; L.B. Zhang; X. Mao; P. Wang
09/01/2015
Circulating tumor cells; Lung cancer; Non-small cell lung cancer

We explored the expression and clinical significance of circulating tumor cells (CTCs) in patients with advanced non-small cell lung cancer (NSCLC). Sixty-six patients with advanced NSCLC at the Oncology Department of Jinzhou Hospital were selected as an observation group between February and December 2013. Healthy volunteers and 20 benign lung disease patients were taken as a control ... more

Y.H. Xu; J. Zhou; X.F. Pan
12/22/2015
AGER; Breast cancer; Lung cancer; Meta-analysis; Polymorphisms

We evaluated the associations between three common polymorphisms in the AGER gene and the risks of breast (BC) and lung (LC) cancer using meta-analysis. A systematic electronic search of the literature was conducted to identify all potential correlation studies in Embase, Web of Science, Cochrane Library, CINAHL, PubMed, CISCOM, China BioMedicine (CBM), and China National ... more

N.C. Yin; X.P. Lang; X.D. Wang; W. Liu

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