Research Article

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Brazilian red pepper essential oil; Ex vivo; Intestinal alkaline phosphatase; Intestinal explants; Sodium butyrate; Swine

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Congenital heart disease; MicroRNA; miR-196a2; Single nucleotide polymorphisms

We hypothesized that single nucleotide polymorphisms (SNPs) in certain microRNAs contribute to congenital heart disease (CHD) phenotypes. Five hundred and seventy-three subjects were enrolled in this study. DNA extracted from peripheral blood cells was used for SNP genotyping of miR-196a2 (rs11614913), miR-27a (rs11671784, rs895819), and miR-499 (rs3746444). Allele ... more

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Endoplasmic reticulum stress; High glucose; Rosuvastatin

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Balanced translocation; Breakpoint; Chromosome 7; Genetic counseling; Male infertility

Balanced reciprocal translocations are associated with reproductive failure. Some reciprocal translocation carriers exhibit azoospermia or oligozoospermia, and an association exists between these chromosomal abnormalities and recurrent abortion. Previous reports have indicated the involvement of chromosome 7 translocations in male infertility and recurrent ... more

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4b/a (VNTR); eNOS polymorphisms; Fabry disease; Glu298Asp; Kidney disease; Renal function parameters

Fabry disease (FD) is an inherited X-linked lysosomal disease that causes renal failure in a high percentage of affected individuals. The eNOS gene encodes for endothelial nitric oxide synthase, which plays an important role in glomerular hemodynamics. This gene has two main polymorphisms (Glu298Asp and 4b/a) that have been studied in the context of many ... more

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