Research Article

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Gout; Metabolic indices; Single nucleotide polymorphism; SLC2A9; ZNF518B

Current evidence suggests that heredity and metabolic syndrome contribute to gout progression. SLC2A9 and ZNF518B may play a role in gout progression in different populations, but no studies have focused on the Tibetan Chinese population. In this study, we determined whether variations in these 2 genes were correlated with gout-related indices in Chinese-Tibetan gout ... more

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Body measurement trait; CIDEC; Meat quality trait; Qinchuan cattle; Single nucleotide polymorphism

Previous studies have shown that the cell death-inducing DFF45-like effector-C (CIDEC) gene is involved in lipid storage and energy metabolism, suggesting that it is a potential candidate gene that affects body measurement traits (BMTs) and meat quality traits (MQTs). The aim of this study was to identify polymorphisms of the bovine CIDEC gene and analyze their possible ... more

C.G. Mei; L.S. Gui; C.Z. Fu; H.C. Wang; J.L. Wang; G. Cheng; L.S. Zan
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Body mass index; Genetic variant; Obesity; PCSK1 gene; POMC gene; Single nucleotide polymorphism

Genetic variants of the POMC and PCSK1 genes cause severe obesity among patients in the early stages of childhood. This family-based study analyzed the links between single nucleotide polymorphisms (SNPs) in either the POMC or PCSK1 genes and obesity, as well as obesity-related traits among obese Thai children and their families. The variants rs1042571 ... more

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Growth arrest and DNA-damage-inducible protein 45 alpha gene; meat quality; Pig; Single nucleotide polymorphism

This study was conducted to evaluate the porcine gene GADD45A (growth arrest and DNA-damage-inducible protein 45 alpha) as a positional candidate controlling quantitative trait loci (QTL) for meat quality traits on chromosome 6 (SSC6). Four exons of the porcine GADD45A gene were defined from cDNA and BAC clone sequences. A total of 4 single nucleotide ... more

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We aimed to explore the correlation between unexplained recurrent spontaneous abortion and polymorphisms in the methylene tetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes. A case control study was conducted in 118 patients with unexplained recurrent spontaneous abortion (abortion group) and 174 healthy women (control group). The genetic ... more

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Single nucleotide polymorphisms (SNPs) are widespread in the Nicotiana genome. Using an alignment and variation detection method, we developed 20,607,973 SNPs, based on the expressed sequence tag sequences of 10 Nicotiana species. The replacement rate was much higher than the transversion rate in the SNPs, and SNPs widely exist in the Nicotiana. In vitro ... more

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Alopecia areata; Association; Single nucleotide polymorphism; Transporter 1 ATP-binding cassette sub-family B

The transporter 1 ATP-binding cassette sub-family B (MDR/TAP) gene (TAP1) is located in the major histocompatibility complex class II region, and forms a heterodimer that plays a key role in endogenous antigen presentation pathways. Investigation of polymorphisms identified in these loci has revealed an association with several autoimmune disorders. Alopecia areata (AA) is a ... more

H.K. Kim; H. Lee; B.L. Lew; W.Y. Sim; Y.O. Kim; S.W. Lee; S. Lee; I.K. Cho; J.T. Kwon; H.J. Kim
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Asian pear; De novo assembly; differential gene expression; Pyrus pyrifolia; Simple sequence repeat; Single nucleotide polymorphism

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J.F. Li; Z. Gao; Y.S. Lou; M. Luo; S.R. Song; W.P. Xu; S.P. Wang; C.X. Zhang
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CTLA4; MECP2; PDCD1; Single nucleotide polymorphism; Systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease that results in chronic inflammation of different organ systems. Several susceptibility loci for SLE have been suggested in different populations, but the nature of the susceptibility genes has yet to be determined. The programmed cell death 1 gene (PDCD1), the cytotoxic T-lymphocyte-associated protein 4 (CTLA4 ... more

H.R. Dong; H.S. Li; S.C. Wang; Q.M. Balin; P.Y. Chang
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Case-control study; COMT; Meta-analysis; Ovarian cancer; Single nucleotide polymorphism; Systematic review

The objective of this study was to perform a systematic review of the correlations between the single nucleotide polymorphism rs4680 in the catechol-O-methyltransferase (COMT) gene and susceptibility to ovarian cancer. A computer search was carried out for relevant case-control studies published between January 2000 to January 2014 in databases such as Ovid, EBSCO, PubMed, CNKI, CBMDISC, VIP, ... more

W. Pan; H. Liao

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