Research Article

Related GMR Articles

07/28/2015
Regulators of G-protein signaling 9 gene; Schizophrenia; Single nucleotide polymorphisms

To identify single-nucleotide polymorphisms that contribute to the genetic susceptibility to schizophrenia, we examined the potential association between schizophrenia and 9 single nucleotide polymorphisms (rs1530351, rs4791230, rs2869577, rs8077696, rs8070231, rs2292592, rs9916525, rs1122079, and rs4790953) in the G-protein signaling 9 gene. The participants included 395 schizophrenia ... more

Y.S. Zhu; Y.X. Li; X.M. Qiao; H.B. Zhang
07/27/2015
Nuclear factor-kB; Ovarian cancer; Single nucleotide polymorphisms

Nuclear factor-κB (NF-κB), a transcription factor that is activated by various stimuli, is associated with the pathogenesis of several cancers. One functional polymorphism, -94 insertion/deletion ATTG (rs28362491), in the human NFKB1 gene (one member of the NF-κB gene family) is associated with increased risk of various cancers. However, only one study has reported that rs28362491 ... more

L.P. Chen; P.S. Cai; H.B. Liang
12/29/2015
Bronchiolitis; Chinese population; ORMDL3 gene; Respiratory viruses; Single nucleotide polymorphisms

Recent studies revealed common genetic risks for both viral bronchiolitis and asthma. Genome-wide association studies revealed that rs7216389 in the ORMDL3 gene is associated with childhood asthma. We conducted a case-control study examining the associations between ORMDL3 polymorphisms (rs7216389, rs12603332, and rs11650680) and bronchiolitis susceptibility/viral findings among ... more

X.T. Liu; L. Ren; L.L. Zhou; Q.Y. Xiao; Y. Deng; E.M. Liu
12/21/2015
Chronic obstructive pulmonary disease; Hypoxia-inducible factor-1α; Single nucleotide polymorphisms

In the present study, we examined whether hypoxia-inducible factor-1α (HIF-1α) polymorphisms are associated with the susceptibility to chronic obstructive pulmonary disease (COPD). One hundred and twenty patients with COPD and 112 healthy controls were recruited from the Han population in Southern China. Polymerase chain reaction-restriction fragment length polymorphism was used to assess ... more

W.T. Wei; B. Li; M. Chen; H.R. Jia; H.X. Zhang
12/15/2015
Anti-inflammatory cytokines; Hematogenous osteomyelitis; Single nucleotide polymorphisms

Osteomyelitis is a progressive bone infection disease caused by destructive immunological inflammatory reactions following new bone formation. Anti-inflammatory cytokines are a series of immunoregulatory molecules that control the pro-inflammatory cytokine response. In this study, we investigated 9 single nucleotide polymorphisms in 5 different cytokine/cytokine receptor genes in hematogenous ... more

A.E. Osman; M. Mubasher; N.E. ElSheikh; H. AlHarthi; I.A. AlAlallah; A.A. Elbeshir; M. Abashar; N. Elsidig; G. ElGhazali; A.S.A. Fadil
12/08/2015
Asthma in children; Brain-derived neurotrophic factor; Single nucleotide polymorphisms

Brain-derived neurotrophic factor (BDNF) promotes synaptic remodeling and modulates the function of other neurotransmitters. Allergic inflammation triggers neuronal dysfunction and structural changes in the airways. Genetic polymorphisms in functional regions of the BDNF gene have a plausible role in modulating the risk of child asthma (CA). This study examined the ... more

J.Y. Wang; A.L. Wang; W. Han; Z.L. Mu
12/02/2015
8-Oxoguanine DNA glycosylase rs1052133; Base excision repair; Lung cancer; poly(ADP-ribose) polymerase 1 rs1136410; Single nucleotide polymorphisms; X-ray repair cross-complementing group 1 rs25487

Base excision repair (BER) plays an important role in maintaining genome integrity and anti-cancer drug resistance. Single nu­cleotide polymorphisms (SNPs) in BER genes were detected in 500 lung cancer patients and 500 cancer-free controls. A logistic regression model was applied to analyze the relationship between lung cancer susceptibility and BER SNPs coupled with a wide range of ... more

X. Wang; K.W. Ma; Y.G. Zhao; G.J. Wang; W. Li
05/06/2016
Asthma; Single nucleotide polymorphisms; Vascular endothelial growth factor

It has been proven that vascular endothelial growth factor (VEGF) is involved in airway restoration and the development of asthma. We sought to examine the relevance of VEGF gene polymorphisms to asthma in the Chinese Han population. We extracted the whole genomic DNA from the peripheral blood of 471 participants, including 226 patients with asthma and 245 healthy controls. Seven ... more

H.Y. Lu; G.L. Zhao; M.F. Fu; H.Y. Lu; G.L. Zhao; M.F. Fu
09/25/2015
Colostrum; Goat; Mature milk; MicroRNA

Immune-related miRNAs in breast milk are extracellular miRNAs that are related to immune organ development and regulation of the immune function in infants and young animals. The goal of this study was to compare the expression levels of five immune-related miRNAs in breast milk in black goats, humans, and dairy cattle. The miRNAs from milk were extracted and the expression levels were ... more

R.S. Na; G.X. E; W. Sun; X.W. Sun; X.Y. Qiu; L.P. Chen; Y.F. Huang
08/28/2015
Differentially expressed gene; MicroRNA; Pancreatic adenocarcinoma

The main aim of this study was to explore the underlying molecular mechanisms and potential target molecules of pancreatic adenocarcinoma. The miRNA (GSE32678) and mRNA (GSE32676) expression profiles of patients with pancreatic ductal adenocarcinoma and healthy controls were downloaded from the Gene Expression Omnibus database. Differentially expressed miRNA and differentially expressed genes ... more

P.F. Liu; W.H. Jiang; Y.T. Han; L.F. He; H.L. Zhang; H. Ren

Pages