Research Article

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08/07/2015
Beta vulgaris; Bioinformatics; EST; GSS; MicroRNA

Highly conserved endogenous non-coding microRNAs (miRNAs) play important roles in plants and animals by silencing genes via destruction or blocking of translation of homologous mRNA. Sugar beet, Beta vulgaris, is one of the most important sugar crops in China, with properties that include wide adaptability and strong tolerance to salinity and impoverished soils. Seedlings of ... more

J.L. Li; J. Cui; D.Y. Cheng
07/28/2015
Gastric cancer; Meta-analysis; MicroRNA; Polymorphism

Gastric cancer (GC) is a prevalent disease with a high mortality rate, especially in developing countries. Accumulating evidence suggests that single nucleotide polymorphisms in microRNA (miRNA) genes might influence the susceptibility to GC; such sequence variation might contribute to the development of disease by altering crucial cellular pathways. In this study, we assessed the ... more

Y.P. Gu; Q.Y. Yuan; H. Zhang; C.J. Wang; F. Zhou
12/28/2015
MicroRNA; miR-494; Pancreatic cancer; Prognosis; Survival

MicroRNA-494 (miR-494) expression is aberrant in various types of human cancer. However, the prognostic value of miR-494 in pancreatic cancer remains unclear. The level of miR-494 expression was determined in 99 pairs of primary pancreatic cancer and their corresponding, adjacent non-tumor tissues by using quantitative reverse transcriptase polymerase chain reaction. We also analyzed the ... more

Y.B. Ma; G.X. Li; J.X. Hu; X. Liu; B.M. Shi
10/29/2015
Alpaca fiber; Dual-luciferase reporter assay system; Fibroblast growth factor 5; MicroRNA

MicroRNAs are very small endogenous RNA molecules that play a crucial role in an array of biological processes, including regulation of skin morphogenesis. The microRNA let-7b is thought to modulate animal hair growth, by binding target genes that encode growth factors. Fibroblast growth factor 5 (FGF5) has been previously reported to be involved in the initiation of the catagen ... more

T. Wang; Y. Zhang; H.D. Wang; Y. Shen; N. Liu; J. Cao; X.J. Yu; C.S. Dong; X.Y. He
01/08/2016
Chronic lymphocytic leukemia; Differentially expressed genes; MicroRNA; Module analysis

Chronic lymphocytic leukemia (CLL) is a disease that involves progressive accumulation of nonfunctioning lymphocytes and has a low cure rate. There is an urgent requirement to determine the molecular mechanism underlying this disease in order to improve the early diagnosis and treatment of CLL. In this study, genes differentially expressed between CLL samples and age-matched controls were ... more

L. Dong; K.H. Bi; N. Huang; C.Y. Chen; L. Dong; K.H. Bi; N. Huang; C.Y. Chen; L. Dong; K.H. Bi; N. Huang; C.Y. Chen
12/06/2017
Gastric cancer; Microarray; MicroRNA; Oncomirs; Precision Medicine; Systems biology; Tumor suppressors
MicroRNAs (miRNAs) are non-coding small RNA molecules that regulate the differential expression of genes. The expression of miRNAs is dysregulated in various types of cancers,
including Gastric Cancer (GC), and has both prognostic and diagnostic potential. To interpret the role of miRNA expression in GC, we evaluated the expression profile using high-throughput miRNA array ... more
F. Bibi; P.Natesan Pushparaj; M.I. Naseer; M. yasir; E.I. Azhar
10/24/2016
Gynophore; MicroRNA sequencing; peanut

Peanut is one of the most important oilseed crops in the world that provides a significant amount of lipids and protein for many people. The gynophore plays an important role in gynophore development after fertilization of the peanut ovule. MicroRNAs (miRNAs) play an important role in numerous developmental and physiological plant ... more

Y. Shen; Y.H. Liu; X.J. Zhang; Q. Sha; Z.D. Chen; Y. Shen; Y.H. Liu; X.J. Zhang; Q. Sha; Z.D. Chen
11/03/2016
GHR; Growth curve; Sex-linked dwarf chickens

Sex-linked dwarf (SLD) chickens have been widely used in cross breeding of broilers and laying hens. To study the molecular mechanisms underlying growth hormone receptor (GHR) in SLD chickens, the expression profiles of GHR were measured in three growth related tissues (liver, breast, and thigh) in male and female S2 SLD chickens at ... more

H.Y. Huang; Z.H. Zhao; S.F. Li; Z. Liang; C.M. Li; Q.B. Wang
11/03/2016
Apoptosis; miR-1; Proliferation; Vestibular schwannoma

A growing body of research has demonstrated the tumor suppressive function of microRNA (miR)-1 in many cancers. Our study aimed to investigate its role in vestibular schwannoma (VS). We examined miR-1 expression in 95 VS specimens and 79 normal vestibular nerves using quantitative real-time polymerase chain reaction. Moreover, miR-1 ... more

S.L. Li; X.H. Ma; J.F. Ji; H. Li; W. Liu; F.Z. Lu; S.T. Wu; Y. Zhang
11/21/2016
Apoptosis; Bcl-xL; Cervical cancer c-33a cells; miRNA 421

Cervical cancer is a life-threatening condition. MicroRNAs (miRNAs) can promote or inhibit cell death and proliferation. The present study investigated the effect of miRNA 421 on the growth and apoptosis of cervical cancer cells. miRNA 421 and control miRNA were synthesized and transfected into c-33a cervical cancer cells. A thiazolyl ... more

X.J. Lai; X.Y. Cheng; L.D. Hu

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