Research Article

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The folate cycle is a biochemical pathway that plays an important role in the development and maintenance of the nervous system. Biocompounds synthesized in this cycle must be carefully regulated, since the accumulation of some substances can be neurotoxic and increase susceptibility to neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and ... more

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Chinese Han population; Dopamine D2 receptor; Heroin dependence; Single nucleotide polymorphism

Heroin dependence is a chronic relapsing brain disease. Researchers have reported that the dopamine D2 receptor (DRD2) is involved in the development of opiate dependence. To identify markers that contribute to the genetic susceptibility to heroin addiction, we examined the potential association between heroin dependence and ... more

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COL9A1; Congenital talipes equinovarus; Polymorphism

Talipes equinovarus is a common congenital deformity. COL9A1 polymorphisms are associated with the development of articular cartilage-related diseases. In the current study, we evaluated the relationship between COL9A1 rs1135056, rs35470562, and rs592121 genetic polymorphisms and risk of congenital talipes equinovarus ... more

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Lung cancer is a common malignant tumor that is characterized by high morbidity and poor prognosis. Studies suggest that an individual’s genetic background affects the risk of developing lung cancer. Therefore, we investigated the relationship between gene polymorphisms and susceptibility to lung cancer. We recruited 308 primary lung ... more

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Idiopathic infertility; p53 polymorphism; Spermatogenesis

Many environmental agents affect the development of male germ cells at different stages. Apoptosis is common during normal spermatogenesis; it plays an important role in controlling the number of germ cells and the disposal of defective stem cells to produce functional sperm. The presence of p53 in primary spermatocytes suggests that it ... more

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