Research Article

Related GMR Articles

09/30/2003
Dopamine; Mutant mouse; Parkinson’s disease

We have identified a new mutant mouse that we have named new mouse neurological mutant 3 (NM3); it may be a useful model to understand the underlying molecular and genetic basis of Parkinson’s disease (PD). A mouse carrying the NM3 mutation arose spontaneously in an RIIIS/J breeding colony and was identified as having a movement disorder. Upon neurological examination of these mice, their ... more

M.E. Legare; W.H. Hanneman
03/12/2014
Dopamine; DRD5; Haplotype; Paranoid schizophrenia; SNP

Dopamine (DA) has been implicated in the pathophysiol­ogy of several psychiatric disorders, including schizophrenia. Thus, genes related to the dopaminergic (DAergic) system are good candidate genes for schizophrenia. One of receptors of the DA receptor system is dopa­mine receptor 5 (DRD5). Single nucleotide polymorphisms (SNPs) in the regulatory regions of DRD5 gene may affect ... more

Y. Zhao; M. Ding; H. Pang; X.M. Xu; B.J. Wang
03/09/2007
Azoospermia; Infertility; Molecular markers; Ring-Y

In the present study, we report on the case of a 43-year-old male patient seeking for fertility assistance, who showed a seminal analysis and testicular biopsy of complete azoospermia. Peripheral blood culture for chromosome studies revealed a karyotype of 46 chromosomes with a ring-Y-chromosome that lost the long arm heterochromatin. Molecular analysis of genomic DNA from the patient detected ... more

F.M. Carvalho; E.V. Wolfgramm; I. Degasperi; B.M. Verbeno; B.A. Vianna; F.F. Chagas; F. Paula; I.D. Louro; A.M.S. Perroni
08/02/2013
Endometriosis; GSTM1; GSTT1; Infertility

Endometriosis is a gynecologic pathology with a high prevalence and unknown etiology. Therefore, an increasing number of studies has been undertaken to search for associations between endometriosis and alterations or polymorphisms in candidate genes, including glutathione S-transferase mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1). We analyzed the frequency of ... more

A.B. Frare; A.M. Barbosa; I.R. Costa; S.R. Souza; R.C.P.C. Silva; B.M. Bordin; C.L.Ribeiro Júnior; K.K.V.O. Moura
05/12/2015
Fluorescence in situ hybridization; Infertility; Reciprocal translocation; Sperm aneuploidy rates

A reciprocal translocation between the short arm of chromosome 1 and the long arm of chromosome 3 was observed in a pedigree of three carriers (proband, and his brother and mother). In this study, the three carriers had different clinical manifestations: the proband with infertility, his brother with spousal miscarriages, and his mother with no adverse reproductive history. Cytogenetic ... more

L.L. Li; Y. Dong; R.X. Wang; N. An; X. Yun; R.Z. Liu
03/06/2015
Clinical adverse reactions; Clinical value; Fluid bolus contrast flow meter; Hysterosalpingography; Infertility; Radiation

The purpose of this study was to investigate the clinical value of the fluid bolus contrast flow meter during hysterosalpingography. Hysterosalpingography information of 342 cases, which included a manual handset group of 213 cases and a bolus instrument group of 129 cases were reviewed. Comparative analysis was used to compare the two groups in order to assess the clinical adverse ... more

Y.P. Ji; Y. Xu; S.Z. Xia; F.Y. Bian; H. Zhang; G.H. Shen
04/27/2016
Anxiety and depression; Infertility; Psychological counseling; Structural chromosome abnormality

Infertility as a psychological problem has gained increasing attention. Male partners among infertile couples have elevated levels of psychological distress, which could affect semen quality, result in hormonal abnormalities, and increase the occurrence of early miscarriage. Infertile women are more vulnerable to psychological distress and require psychological support. Subfertile women ... more

H.L. Wang; B. Wu; K.M. Guo; R.H. Tian; H.L. Wang; B. Wu; K.M. Guo; R.H. Tian; H.L. Wang; B. Wu; K.M. Guo; R.H. Tian
09/27/2017
Animals; Anovulation; Brain; Female; Interleukin-6; Leptin; Lipid metabolism; Mice; Mice, Obese; Receptor Protein-Tyrosine Kinases; Receptors, GABA; Receptors, Muscarinic; Receptors, Serotonin; Synaptic Transmission

Polycystic ovary syndrome is the classic example of loss of functional cyclicity and anomalous feedback. In this case, the excessive extra-glandular production and conversion of androgens to estrogens are the pathophysiological basis of the chronic anovulation. The literature describes an experimental model of the polymicrocystic ovary in obese diabetic mice with insulin resistance. The fact ... more

M.A. Azevedo; I.D.C.G. Silva