Research Article

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09/01/2015
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We explored the expression and clinical significance of circulating tumor cells (CTCs) in patients with advanced non-small cell lung cancer (NSCLC). Sixty-six patients with advanced NSCLC at the Oncology Department of Jinzhou Hospital were selected as an observation group between February and December 2013. Healthy volunteers and 20 benign lung disease patients were taken as a control ... more

Y.H. Xu; J. Zhou; X.F. Pan
12/22/2015
AGER; Breast cancer; Lung cancer; Meta-analysis; Polymorphisms

We evaluated the associations between three common polymorphisms in the AGER gene and the risks of breast (BC) and lung (LC) cancer using meta-analysis. A systematic electronic search of the literature was conducted to identify all potential correlation studies in Embase, Web of Science, Cochrane Library, CINAHL, PubMed, CISCOM, China BioMedicine (CBM), and China National ... more

N.C. Yin; X.P. Lang; X.D. Wang; W. Liu
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8-Oxoguanine DNA glycosylase rs1052133; Base excision repair; Lung cancer; poly(ADP-ribose) polymerase 1 rs1136410; Single nucleotide polymorphisms; X-ray repair cross-complementing group 1 rs25487

Base excision repair (BER) plays an important role in maintaining genome integrity and anti-cancer drug resistance. Single nu­cleotide polymorphisms (SNPs) in BER genes were detected in 500 lung cancer patients and 500 cancer-free controls. A logistic regression model was applied to analyze the relationship between lung cancer susceptibility and BER SNPs coupled with a wide range of ... more

X. Wang; K.W. Ma; Y.G. Zhao; G.J. Wang; W. Li
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Doxorubicin; Lung cancer; Meloxicam; MRP; Xenograft

It has been suggested that selected COX inhibitors can overcome multidrug resistance through the inhibition of ATP‑binding cassette-transporter proteins thereby enhancing the inhibitory effect of doxorubicin on human tumor growth and promoting the actions of cytostatics. However, their effect on lung cancer and the molecular mechanisms involved in the overcoming of multidrug resistance ... more

S.F. Chen; Z.Y. Zhang; J.L. Zhang
04/07/2016
A1298C; C677T; Lung cancer; Meta-analysis; MTHFR; Polymorphisms

Results from previous studies on the association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms C677T and A1298C and lung cancer have been conflicting. The aim of this meta-analysis was to clarify the effect of MTHFR polymorphisms on the risk of lung cancer. An electronic search of PubMed, EMBASE, the Cochrane library, and the China Knowledge Resource ... more

Y. Yang; L.J. Yang; M.Z. Deng; Y.Y. Luo; S. Wu; L. Xiong; D. Wang; Y. Liu; H. Liu; Y. Yang; L.J. Yang; M.Z. Deng; Y.Y. Luo; S. Wu; L. Xiong; D. Wang; Y. Liu; H. Liu; Y. Yang; L.J. Yang; M.Z. Deng; Y.Y. Luo; S. Wu; L. Xiong; D. Wang; Y. Liu; H. Liu
07/03/2015
Camellia sinensis (L.) O. Kuntze; cluster analysis; Codon usage bias; Correlation analysis; ENC-plot; SPDS

The spermidine synthase (SPDS) gene exists widely in all types of plants. In this paper, the codon usage of the SPDS gene from Camellia sinensis (CsSPDS) was analyzed. The results showed that the codon usage of the CsSPDS gene is biased towards the T-ended or A-ended codons, which is similar to that observed in 73 genes selected from the C ... more

E. You; Y. Wang; Z.T. Ding; X.F. Zhang; L.L. Pan; C. Zheng
11/13/2015
Articular cartilage bone; Correlation analysis; Interleukin-6; Osteoarthritis

This study aimed to investigate the expressional profile of interleukin-6 (IL-6) in articular cartilage bone of osteoarthritis (OA) patients and its correlation with OA. A total of 30 articular cartilage bone samples from knee OA patients, which were collected by knee arthroscopy or articular surgery, comprised the study group, and 30 samples of normal articular cartilage tissue comprised ... more

X.Q. Qu; W.J. Wang; S.S. Tang; Y. Liu; J.L. Wang
03/04/2016
Correlation analysis; Desmoglein 4; Diversity; Evolution; Goat

Desmoglein 4 (DSG4) has an important role in the development of wool traits in domestic animals. The full-length DSG4 gene, which contains 3918 bp, a complete open-reading-frame, and encodes a 1040-amino acid protein, was amplified from Liaoning cashmere goat. The sequence was compared with that of DSG4 from other animals and the results show that the DSG4 ... more

G.X. E; Y.J. Zhao; Y.H. Ma; G.L. Cao; J.N. He; R.S. Na; Z.Q. Zhao; C.D. Jiang; J.H. Zhang; S. Arlvd; L.P. Chen; X.Y. Qiu; W. Hu; Y.F. Huang; G.X. E; Y.J. Zhao; Y.H. Ma; G.L. Cao; J.N. He; R.S. Na; Z.Q. Zhao; C.D. Jiang; J.H. Zhang; S. Arlvd; L.P. Chen; X.Y. Qiu; W. Hu; Y.F. Huang
09/28/2015
Case-control study; Dental caries; Gene polymorphism; Vitamin D receptor

Environmental influences on the development and progression of dental caries are well known; however, there is little evidence of a genetic component imparting susceptibility to dental caries. The aim of this study was to investigate the relationship between a single nucleotide polymorphism in the vitamin D receptor TaqI locus and dental caries susceptibility in a Chinese ... more

X.P. Hu; Z.Q. Li; J.Y. Zhou; Z.H. Yu; J.M. Zhang; M.L. Guo
09/09/2015
Arg188His; Gene polymorphism; Ovarian cancer; X-ray repair cross-complementing group 2 (XRCC2)

Numerous studies have evaluated the association between the Arg188His polymorphism of the X-ray repair cross-complementing group 2 (XRCC2) gene and ovarian cancer risk. However, the specific association is still controversial. This meta-analysis was therefore designed to clarify these controversies. Relevant case-control studies were enrolled in the meta-analysis. Quality ... more

M. Zhai; Y. Wang; M.F. Jiang

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