Research Article

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07/15/2013
High-performance capillary electrophoresis; IL-4; Ischemic stroke; Uyghur population; Variable number of tandem repeats

Ischemic stroke (IS) is a multifactorial disorder, and genetic factors act as important contributors to its onset and progression. Inflammation is a key event that is closely associated with the pathophysiology of IS. The association of genetic polymorphisms of inflammatory cytokines with IS remains poorly understood. We investigated the relationship between the variable number of tandem ... more

Y.Q. Tong; J.J. Ye; Z.H. Wang; Y.W. Zhang; F.X. Zhan; X.H. Guan; Y.J. Geng; S.Y. Hou; Y. Li; J.Q. Cheng; Z.X. Lu; J.F. Liu
02/28/2014
Asthma; IL-4; Meta-analysis; Polymorphisms; Promoter

This study aimed to more precisely assess the correlation between interleukin-4 (IL-4) promoter polymorphisms and the susceptibility risk of asthma. We conducted association studies on IL-4 promoter C-33T, C-589T, and G-1098T polymorphisms with asthma using data obtained from MEDLINE up to September 2011. Results showed that the polymorphisms IL-4 C-33T and C-589T were significantly ... more

L. Tang; H.G. Lin; B.F. Chen
07/29/2016
Cytokines; IL-18; IL-4; Non-Hodgkin’s lymphoma

Strong evidence indicates that tumor growth can be actively controlled by the immune system, and interleukins (ILs) are known to play an influential role in immune response regulation. Moreover, inflammatory cytokines are significantly involved in lymphoma pathogenesis. We aimed to investigate serum levels of IL-4 and IL-18 in aggressive non-Hodgkin’s lymphoma (A-NHL) patients and their ... more

H.O. Soydinc; N. Guney; M. Basaran; D. Duranyildiz; V. Yasasever; H.O. Soydinc; N. Guney; M. Basaran; D. Duranyildiz; V. Yasasever
08/14/2015
8-Hydroxy deoxyguanosine; DNA damage; Smoking; Tobacco; Waterpipe

Waterpipe tobacco smoking is increasing in popularity, particularly among young adults. This popularity is related to the lack knowledge regarding the health effects of waterpipe smoking. In this study, we examined the genotoxicity of waterpipe smoking using an 8-hydroxy deoxyguanosine (8-OHdG) assay. Genotoxicity was evaluated in the saliva, urine, and serum of 66 waterpipe adult smokers ... more

M. Azab; O.F. Khabour; K.H. Alzoubi; S.A.H. Mahmoud; M. Anabtawi; M. Quttina
07/31/2015
Aging; FOXO3; PI3K/Akt; Signaling pathway; Smoking

We investigated the effects of smoking and aging on pro­teins involved in the forkhead box O3 (FOXO3) signaling pathways in the lungs. Sixteen senescence-accelerated mouse-resistant 1 (SAMR1) and senescence-accelerated mouse-prone 8 (SAMP8) mice at 3 months of age were divided into a normally aged, smoke-exposed group (4 SAMR1 mice), a normally aged, air-exposed group (4 SAMR1 mice), an ... more

Y.M. Yuan; L. Luo; Z. Guo; M. Yang; Y.F. Lin; C. Luo
01/04/2016
CYP1 A1; Gene polymorphism; Non-small cell lung cancer; Smoking

Many studies have shown that genetic factors, environmental factors, and bad living habits, especially smoking, are risk factors for lung cancer. However, not all smokers develop lung cancer, which may be related to different genetic backgrounds. Currently, most research has investigated the GSTM1, XRCC1, XRCC3, CYP2D6, and C188T genes. Little ... more

Y.Q. Xie; J.M. Chen; Y. Liu
12/22/2015
Alcohol; Colorectal neoplasms; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2E1; Genetic polymorphisms; Smoking

Polymorphisms in genes encoding P450 cytochrome enzymes may increase the risk of sporadic colorectal cancer (SCRC). Here we investigated the association between SCRC and CYP2E1 (PstI) and CYP1A1 (MspI) polymorphisms in a case-control study. Moreover, we sought to determine any possible associations between this disease and the sociodemographic factors. ... more

M.A. Proença; G.M.M. Fernandes; A. Russo; R.B. Lelis; J.G. Netinho; G.S. Cunrath; A.E. Silva; E.M. Goloni-Bertollo; E.C. Pavarino
3/15/2017
Atherosclerosis; Female; Genetic association studies; Genetic predisposition to disease; Genotype; Glutathione transferase; Humans; male; Middle Aged; Polymorphism, Genetic; Risk factors; Smoking

Atherosclerosis is characterized by lesions, called atheroma or atheromatous plaques, in the inner layer of blood vessels, which block the vascular lumen and weaken the underlying tunica media. Several modifiable and non-modifiable risk factors for the development of atherosclerosis exist. The modifiable risk factors include hypertension, smoking, obesity, high LDL and low HDL cholesterol ... more

D.A. Rodrigues; J.V.M. Martins; K.S.F.E. Silva; I.R. Costa; M.H. Lagares; F.L. Campedelli; A.M. Barbosa; M.P. de Morais; K.K.V.O. Moura
3/30/2017
Adult; Aged; Aged, 80 and over; Alleles; Asian People; Case-control studies; Female; Genetic association studies; Genetic predisposition to disease; Humans; Interleukin-17; Laryngeal Neoplasms; male; Middle Aged; Polymorphism, Single Nucleotide; Risk factors; Smoking

IL-17 is associated with the occurrence and development of laryngeal cancer. However, no study has reported the association between IL-17 polymorphisms and laryngeal cancer susceptibility. Therefore, we analyzed the association of three polymorphism loci (rs2275913, 197 G/A; rs3748067, 383 A/G; and rs763780, 7488 T/C) of IL-17A and IL-17F with laryngeal cancer in the Chinese population. A case ... more

F.Z. Si; Y.Q. Feng; M. Han
08/17/2017
Alcohol Drinking; Atherosclerosis; Case-control studies; Diabetes mellitus; Humans; Polymorphism, Single Nucleotide; Smoking; Tumor Suppressor Protein p53

Atherosclerosis is a multifactorial pathological disease that alters the morphology and function of arterial walls. The atheroma growth leads to vessel hardening and lumen narrowing, limiting the blood flow. The atheroma plaque can eventually break, expose highly thrombogenic material and lead to platelet activation and subsequent formation of a thrombus that may block blood flow in loco, or ... more

M.H. Lagares; K.S.F. Silva; A.M. Barbosa; D.A. Rodrigues; I.R. Costa; J.V.M. Martins; M.P. Morais; F.L. Campedelli; K.K.V.O. Moura

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