Research Article

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Ischemia/reperfusion (I/R) injury often triggers ventricular arrhythmia. Citrate binds calcium ions, forming a soluble calcium citrate complex that may reduce I/R injury by affecting calcium ion concentration. We tested the effects of citrate pretreatment on ventricular heart rate and related factors in a rat I/R model. Fifty male Sprague Dawley rats weighing 350- ... more

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Bacterial killing; CD209a; Helicobacter pylori; LECT2; Macrophages; NF-κB

Helicobacter pylori employs unique methods to colonize the stomach, which induces chronic inflammation. It is also able to avoid eradication by macrophages and other immune cells. Leukocyte cell-derived chemotaxin 2 (LECT2), a multi-functional cytokine involved in many pathological conditions, has recently been shown to activate macrophages via the CD209a ... more

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Age distribution; Cervical cancer; Human papilloma virus; Multiple infection; Subtype distribution

The aim of this study was to examine the subtype distribution of human papilloma virus (HPV) in women in the Shaanxi Province of China. A DNA chip, along with polymerase chain reaction amplification and reverse dot blot technology, was adopted to analyze the HPV genotypes of 22,937 cases of cervical cell specimens. The HPV infection ... more

J. Li; Y.Y. Wang; X.F. Tian; X. Nan; T. Yan; P. Wang; Y.L. Fu; G.Q. Wang
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Gestational diabetes mellitus; Meta-analysis; PPARs; Pro12Ala polymorphism

The relationship between the Pro12Ala polymorphism of PPARγ and the risk of gestational diabetes mellitus remains unresolved. Here, we attempted to resolve this inconsistency. Case-control studies pertaining to the effect of the Pro12Ala polymorphism in the PPARγ protein and risk of gestational diabetes mellitus were extracted from the ... more

H.L. Shuai; X.Z. Lin; D.L. Chen; P. Li; X. Luo
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Deciduous teeth; Pathway analyses; Pathway-related modules; Permanent teeth; Reverse transcription-polymerase chain reaction

The differences in genetic backgrounds between deciduous and permanent teeth might contribute to the differences in developmental processes, histological characteristics, and tooth life cycles. Here, we attempted to identify significantly different modules between permanent and deciduous teeth via network and pathway analyses. We ... more

J. Kang; R. Bai; K. Liu; X.P. Ji; Y. Li; J.Y. Han
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IL10 haplotypes; IL10 polymorphisms; Linkage disequilibrium; Mexican Mestizo population; Western Mexico

Interleukin 10 (IL-10) is an immunoregulatory cytokine with multiple roles in the immune system. Three single nucleotide polymorphisms at positions -1082 (A>G), -819 (C>T), and -592 (C>A) in the promoter region of the IL10 gene are believed to be associated with different inflammatory, infectious, and autoimmune ... more

M. Vázquez-Villamar; C.A. Palafox-Sánchez; J. Hernández-Bello; J.F. Muñoz-Valle; Y. Valle; A. Cruz; A.I. Alatorre-Meza; E. Oregon-Romero
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Chinese Han population; Dopamine D2 receptor; Heroin dependence; Single nucleotide polymorphism

Heroin dependence is a chronic relapsing brain disease. Researchers have reported that the dopamine D2 receptor (DRD2) is involved in the development of opiate dependence. To identify markers that contribute to the genetic susceptibility to heroin addiction, we examined the potential association between heroin dependence and ... more

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11/03/2016
COL9A1; Congenital talipes equinovarus; Polymorphism

Talipes equinovarus is a common congenital deformity. COL9A1 polymorphisms are associated with the development of articular cartilage-related diseases. In the current study, we evaluated the relationship between COL9A1 rs1135056, rs35470562, and rs592121 genetic polymorphisms and risk of congenital talipes equinovarus ... more

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Correlation analysis; CYP1A1, GSTP1, ERCC2, XRCC1, XRCC3; Gene polymorphism; Lung cancer

Lung cancer is a common malignant tumor that is characterized by high morbidity and poor prognosis. Studies suggest that an individual’s genetic background affects the risk of developing lung cancer. Therefore, we investigated the relationship between gene polymorphisms and susceptibility to lung cancer. We recruited 308 primary lung ... more

H.X. Liu; J. Li; B.G. Ye; H.X. Liu; J. Li; B.G. Ye
11/03/2016
Classic Kaposi sarcoma; miR-146a; miR-149; Polymorphism

Classic Kaposi sarcoma is a type of vascular proliferative inflammatory disease. Previous studies have reported significant associations between microRNAs expression and the development of classic Kaposi sarcoma. Here, we conducted a case-control study to investigate the association between miR-146a and miR-149 genetic polymorphisms and ... more

H. Yang; Q.L. Lu; X.J. Wu; H.Y. Ma; Y.Y. Qu; D.Z. Zhang; X.M. Pu

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