Research Article

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11/03/2016
Classic Kaposi sarcoma; miR-146a; miR-149; Polymorphism

Classic Kaposi sarcoma is a type of vascular proliferative inflammatory disease. Previous studies have reported significant associations between microRNAs expression and the development of classic Kaposi sarcoma. Here, we conducted a case-control study to investigate the association between miR-146a and miR-149 genetic polymorphisms and ... more

H. Yang; Q.L. Lu; X.J. Wu; H.Y. Ma; Y.Y. Qu; D.Z. Zhang; X.M. Pu
11/03/2016
Idiopathic infertility; p53 polymorphism; Spermatogenesis

Many environmental agents affect the development of male germ cells at different stages. Apoptosis is common during normal spermatogenesis; it plays an important role in controlling the number of germ cells and the disposal of defective stem cells to produce functional sperm. The presence of p53 in primary spermatocytes suggests that it ... more

M.P. de Morais; R.F. Curado; K.S.Fe Silva; K.K.V.O. Moura; J.T. Arruda
11/03/2016
Apoptosis; miR-1; Proliferation; Vestibular schwannoma

A growing body of research has demonstrated the tumor suppressive function of microRNA (miR)-1 in many cancers. Our study aimed to investigate its role in vestibular schwannoma (VS). We examined miR-1 expression in 95 VS specimens and 79 normal vestibular nerves using quantitative real-time polymerase chain reaction. Moreover, miR-1 ... more

S.L. Li; X.H. Ma; J.F. Ji; H. Li; W. Liu; F.Z. Lu; S.T. Wu; Y. Zhang
11/03/2016
CG15269; CG15436; Crol; PARIS; PGC-1α; Spargel

Mitochondrial destruction leads to the formation of reactive oxygen species, increases cellular stress, causes apoptotic cell death, and involves a cascade of proteins including PARKIN, PINK1, and Mitofusin2. Mitochondrial biogenesis pathways depend upon the activity of the protein PGC-1α. These two processes are coordinated by the ... more

E.M. Merzetti; B.E. Staveley
11/03/2016
Alpha-actinin 3; Angiotensin-converting enzyme; Muscle fiber; Polymorphism; Scoliosis

The etiology of adolescent idiopathic scoliosis remains unknown. Angiotensin-converting enzyme and α-actinin-3 polymorphisms influence the characteristics of muscle fibers. The aim of this study was to examine the association between idiopathic scoliosis and genetic polymorphism of angiotensin-converting enzyme and α-actinin-3. Ninety-seven females with scoliosis, ... more

R.P. Luciano; M. Wajchenberg; S.S. Almeida; C.E.N. Amorim; L.M.R. Rodrigues; R.C. Araujo; E.B. Puertas; F. Faloppa; R.P. Luciano; M. Wajchenberg; S.S. Almeida; C.E.N. Amorim; L.M.R. Rodrigues; R.C. Araujo; E.B. Puertas; F. Faloppa
11/03/2016
ICAM-1; IL-6; IL-8; Myocardial ischemia-reperfusion; NF-κB; Total peony glycoside

Early recovery of myocardial perfusion is beneficial for myocardial ischemia. However, ischemia-reperfusion (I/R) may exacerbate myocardial injury. Research shows that total peony glucoside (TPG) can inhibit ischemic myocardial cell apoptosis. However, whether it can ameliorate I/R injury remains poorly understood. This study explored the effect of TPG pretreatment ... more

L. Lu; P. Wei; Y. Cao; Q. Zhang; M. Liu; X.D. Liu; Z.L. Wang; P.Y. Zhang; L. Lu; P. Wei; Y. Cao; Q. Zhang; M. Liu; X.D. Liu; Z.L. Wang; P.Y. Zhang
11/03/2016
Endophytes; Enzymes; Fungi; Phylogenetic analysis

Plants of medicinal and economic importance have been studied to investigate the presence of enzyme-producing endophytic fungi. The characterization of isolates with distinct enzyme production potential may identify suitable alternatives for specialized industry. At Universidade Estadual de Maringá Laboratory of Microbial Biotechnology, approximately 500 isolates ... more

R.N. Alberto; A.T. Costa; J.C. Polonio; M.S. Santos; S.A. Rhoden; J.L. Azevedo; J.A. Pamphile; R.N. Alberto; A.T. Costa; J.C. Polonio; M.S. Santos; S.A. Rhoden; J.L. Azevedo; J.A. Pamphile
11/03/2016
Liguistium wallichii; NF-κB; Renal carcinoma; UBE3A

Renal carcinoma accounts for a fifth of the morbidity among malignant tumors in China. Ubiquitin-protein ligase E3A (UBE3A) plays an important role in the occurrence and development of gene mutation-induced diseases. This study was designed to investigate the mechanism of Liguistium wallichii in treating renal carcinoma. Hematoxylin and eosin staining was ... more

J.S. Wu; P.M. Zhang; L.J. Sun; X.Z. Liu; J.S. Wu; P.M. Zhang; L.J. Sun; X.Z. Liu; J.S. Wu; P.M. Zhang; L.J. Sun; X.Z. Liu
11/03/2016
Keratoconus; Mutation; Next-generation sequencing; VSX1

The aim of this study was to screen the visual system homeobox 1 (VSX1) gene in Turkish patients with keratoconus (KC). The patient group consisted of 44 patients who had undergone corneal transplant surgery before the age of 30, for advanced and rapidly progressive KC. The control group comprised 250 healthy individuals. We ... more

H. Bardak; M. Gunay; E. Yildiz; Y. Bardak; B. Gunay; H. Ozbas; O. Bagci
11/03/2016
Combined treatment; Diabetes; Inflammatory factors; Tear; Traditional Chinese medicine; Xerophthalmia

Diabetes-induced xerophthalmia is a general metabolic disorder with high incidence and increased treatment difficulty. Our study aimed to explore the combined effect of traditional Chinese and Western medicines on diabetes-associated xerophthalmia. We recruited 60 diabetic xerophthalmia patients, and randomly assigned them to either the control (Western medicine ... more

S.Q. Wu; Q. Dai; J.L. Xu; W.Y. Sheng; Q.B. Xu; L.Y. Zhong; S.Q. Wu; Q. Dai; J.L. Xu; W.Y. Sheng; Q.B. Xu; L.Y. Zhong; S.Q. Wu; Q. Dai; J.L. Xu; W.Y. Sheng; Q.B. Xu; L.Y. Zhong

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