Research Article

Related GMR Articles

11/03/2016
COL9A1; Congenital talipes equinovarus; Polymorphism

Talipes equinovarus is a common congenital deformity. COL9A1 polymorphisms are associated with the development of articular cartilage-related diseases. In the current study, we evaluated the relationship between COL9A1 rs1135056, rs35470562, and rs592121 genetic polymorphisms and risk of congenital talipes equinovarus ... more

X.L. Zhao; Y.J. Wang; Y.L. Wu; W.H. Han
11/21/2016
IL-8; Meta-analysis; Periodontitis; Polymorphism

The -251A/T polymorphism in the anti-inflammatory cytokine interleukin-8 (IL-8) gene has been implicated in susceptibility to periodontitis; however, this correlation has not been elucidated. In this meta-analysis, we investigated the association between the IL-8 -251A/T polymorphism and the risk of periodontitis. All eligible case-control studies ... more

Z.J. Yang; X.P. Tang; Q.G. Lai; J.B. Ci; K.F. Yuan; Z.J. Yang; X.P. Tang; Q.G. Lai; J.B. Ci; K.F. Yuan; Z.J. Yang; X.P. Tang; Q.G. Lai; J.B. Ci; K.F. Yuan
10/17/2016
-1082A/G; -592A/C; CAD; IL-10; Polymorphism

Here, we conducted a case-control study to investigate the association between IL-10 gene polymorphisms and development of CAD in a Chinese population. A total of 220 patients with CAD and 236 control subjects who visited the Zhengzhou People’s Hospital between May 2012 and June 2014 were selected for this study. The IL-10-1082A/G and -592A/C ... more

L. Wu; M.H. Zhao; G.Y. Geng; L. Mao; H.J. Liu
10/17/2016
IL-8; Polymorphism; Primary gouty arthritis; rs2227306; rs4073

In this study, we investigated the role of two single nucleotide polymorphisms in the promoter region of the interleukin-8 gene (IL-8; rs4073 and rs2227306) in the susceptibility to primary gouty arthritis in a Chinese population. Three hundred and twelve patients with primary gouty arthritis and 340 healthy controls were recruited from the Yan’an ... more

Y.X. Cui; H. Zhao; H.Q. Guo
10/17/2016
Epinephelus coioides; IGF1Ra; IGF1Rb; Nucleotide diversity; Polymorphism

Orange-spotted grouper (Epinephelus coioides) is one of the most important marine fish and has a high market value. The insulin-like growth factor type 1 receptor (IGF1R) is a component of the insulin-like growth factor signaling system, and demonstrates important roles during growth. Based on information from livestock, we ... more

L. Guo; S. Yang; M.M. Li; Z.N. Meng; H.R. Lin; L. Guo; S. Yang; M.M. Li; Z.N. Meng; H.R. Lin
10/24/2016
-372C/G; -607A/C; Coronary artery disease; IL-18; Polymorphism

Coronary artery disease (CAD) has a high mortality rate in several countries. Interleukin (IL)-18 has been previously correlated with atherosclerotic plaque rupture. In this case-control study, the relationship between -607A/C and -372C/G promoter polymorphisms in IL-18 and risk of CAD development was investigated. A total of 326 CAD patients were ... more

J.B. Ma; L. Chen; B. Gao; J. Xu
11/03/2016
Classic Kaposi sarcoma; miR-146a; miR-149; Polymorphism

Classic Kaposi sarcoma is a type of vascular proliferative inflammatory disease. Previous studies have reported significant associations between microRNAs expression and the development of classic Kaposi sarcoma. Here, we conducted a case-control study to investigate the association between miR-146a and miR-149 genetic polymorphisms and ... more

H. Yang; Q.L. Lu; X.J. Wu; H.Y. Ma; Y.Y. Qu; D.Z. Zhang; X.M. Pu
11/03/2016
Gestational diabetes mellitus; Meta-analysis; PPARs; Pro12Ala polymorphism

The relationship between the Pro12Ala polymorphism of PPARγ and the risk of gestational diabetes mellitus remains unresolved. Here, we attempted to resolve this inconsistency. Case-control studies pertaining to the effect of the Pro12Ala polymorphism in the PPARγ protein and risk of gestational diabetes mellitus were extracted from the ... more

H.L. Shuai; X.Z. Lin; D.L. Chen; P. Li; X. Luo
11/03/2016
Chinese Han population; Dopamine D2 receptor; Heroin dependence; Single nucleotide polymorphism

Heroin dependence is a chronic relapsing brain disease. Researchers have reported that the dopamine D2 receptor (DRD2) is involved in the development of opiate dependence. To identify markers that contribute to the genetic susceptibility to heroin addiction, we examined the potential association between heroin dependence and ... more

N. Wang; J.B. Zhang; J. Zhao; X.T. Cai; Y.S. Zhu; S.B. Li; N. Wang; J.B. Zhang; J. Zhao; X.T. Cai; Y.S. Zhu; S.B. Li

Pages