Research Article

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11/03/2016
Alpha-actinin 3; Angiotensin-converting enzyme; Muscle fiber; Polymorphism; Scoliosis

The etiology of adolescent idiopathic scoliosis remains unknown. Angiotensin-converting enzyme and α-actinin-3 polymorphisms influence the characteristics of muscle fibers. The aim of this study was to examine the association between idiopathic scoliosis and genetic polymorphism of angiotensin-converting enzyme and α-actinin-3. Ninety-seven females with scoliosis, ... more

R.P. Luciano; M. Wajchenberg; S.S. Almeida; C.E.N. Amorim; L.M.R. Rodrigues; R.C. Araujo; E.B. Puertas; F. Faloppa; R.P. Luciano; M. Wajchenberg; S.S. Almeida; C.E.N. Amorim; L.M.R. Rodrigues; R.C. Araujo; E.B. Puertas; F. Faloppa
11/21/2016
IL-8; Meta-analysis; Periodontitis; Polymorphism

The -251A/T polymorphism in the anti-inflammatory cytokine interleukin-8 (IL-8) gene has been implicated in susceptibility to periodontitis; however, this correlation has not been elucidated. In this meta-analysis, we investigated the association between the IL-8 -251A/T polymorphism and the risk of periodontitis. All eligible case-control studies ... more

Z.J. Yang; X.P. Tang; Q.G. Lai; J.B. Ci; K.F. Yuan; Z.J. Yang; X.P. Tang; Q.G. Lai; J.B. Ci; K.F. Yuan; Z.J. Yang; X.P. Tang; Q.G. Lai; J.B. Ci; K.F. Yuan
11/26/2013
ABCB1; Carbamazepine; Complex partial seizure; G2677T; Malaysians

Carbamazepine (CBZ) is used as the first line of treatment of complex partial seizures (CPS) in Malaysia. While this drug is known to be effective for the treatment of CPS, more than 30% of patients remain drug resistant to CBZ mono-therapy. We examined a possible relationship between patients’ response to CBZ mono-therapy and the G2677T SNP of the ABCB1 gene. Three hundred and fourteen ... more

S. Subenthiran; N.R. Abdullah; P.K. Muniandy; J.P. Joseph; K.C. Cheong; Z. Ismail; Z. Mohamed
03/11/2013
ABCB1; Epigenetics; HRM-PCR; Methylation

Multidrug resistance is the major cause of cancer chemotherapy failure. This phenotype is mainly due to the overexpression of the human ABCB1 gene. Several studies have shown that the transcriptional regulation of this gene is complex. Yet, the impact of this transcriptional regulation has not been well studied in a clinical setting. The acquired expression of ABCB1 is ... more

A.L. Mencalha; E.F. Rodrigues; E. Abdelhay; T.S. Fernandez
02/13/2015
ABCB1; Breast cancer; MDR1; Polymorphisms; Pre- and postmenopausal women

MDR1, which is encoded by the ABCB1 gene, is involved in multidrug resistance (hydrophobic), as well as the elimination of xenotoxic agents. The association between ABCB1 gene polymorphisms and breast cancer risk in different populations has been described previously; however, the results have been inconclusive. In this study, we examined the association between ... more

S.A. Gutiérrez-Rubio; A. Quintero-Ramos; A. Durán-Cárdenas; R.A. Franco-Topete; J.M. Castro-Cervantes; A. Oceguera-Villanueva; L.M. Jiménez-Pérez; L.M.A. Balderas-Peña; G. Morgan-Villela; A. Del-Toro-Arreola; A. Daneri-Navarro
09/02/2016
ABCB1; Acute leukemia; C1236T; C3435T; Polymorphism

We carried out a case-control study to examine the relationship between the ATP-binding cassette subfamily B member 1 (ABCB1) gene polymorphisms C1236T, G2677T, and C3435T and risk of acute leukemia in a Chinese population. Between May 2013 and April 2015, we recruited 164 acute leukemia patients and 285 healthy controls, and determined polymorphism genotypes by polymerase chain ... more

R. Feng; H.X. Zhang; H.G. Zhang; C.F. Zhang; R. Feng; H.X. Zhang; H.G. Zhang; C.F. Zhang
11/03/2016
Age distribution; Cervical cancer; Human papilloma virus; Multiple infection; Subtype distribution

The aim of this study was to examine the subtype distribution of human papilloma virus (HPV) in women in the Shaanxi Province of China. A DNA chip, along with polymerase chain reaction amplification and reverse dot blot technology, was adopted to analyze the HPV genotypes of 22,937 cases of cervical cell specimens. The HPV infection ... more

J. Li; Y.Y. Wang; X.F. Tian; X. Nan; T. Yan; P. Wang; Y.L. Fu; G.Q. Wang
11/03/2016
Gestational diabetes mellitus; Meta-analysis; PPARs; Pro12Ala polymorphism

The relationship between the Pro12Ala polymorphism of PPARγ and the risk of gestational diabetes mellitus remains unresolved. Here, we attempted to resolve this inconsistency. Case-control studies pertaining to the effect of the Pro12Ala polymorphism in the PPARγ protein and risk of gestational diabetes mellitus were extracted from the ... more

H.L. Shuai; X.Z. Lin; D.L. Chen; P. Li; X. Luo
11/03/2016
Deciduous teeth; Pathway analyses; Pathway-related modules; Permanent teeth; Reverse transcription-polymerase chain reaction

The differences in genetic backgrounds between deciduous and permanent teeth might contribute to the differences in developmental processes, histological characteristics, and tooth life cycles. Here, we attempted to identify significantly different modules between permanent and deciduous teeth via network and pathway analyses. We ... more

J. Kang; R. Bai; K. Liu; X.P. Ji; Y. Li; J.Y. Han
11/03/2016
IL10 haplotypes; IL10 polymorphisms; Linkage disequilibrium; Mexican Mestizo population; Western Mexico

Interleukin 10 (IL-10) is an immunoregulatory cytokine with multiple roles in the immune system. Three single nucleotide polymorphisms at positions -1082 (A>G), -819 (C>T), and -592 (C>A) in the promoter region of the IL10 gene are believed to be associated with different inflammatory, infectious, and autoimmune ... more

M. Vázquez-Villamar; C.A. Palafox-Sánchez; J. Hernández-Bello; J.F. Muñoz-Valle; Y. Valle; A. Cruz; A.I. Alatorre-Meza; E. Oregon-Romero

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