Research Article

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2016 Nov 21
Apoptosis; bcl-X Protein; Cell Line, Tumor; Cell proliferation; Cell survival; Female; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Uterine cervical neoplasms

Cervical cancer is a life-threatening condition. MicroRNAs (miRNAs) can promote or inhibit cell death and proliferation. The present study investigated the effect of miRNA 421 on the growth and apoptosis of cervical cancer cells. miRNA 421 and control miRNA were synthesized and transfected into c-33a cervical cancer cells. A thiazolyl blue tetrazolium bromide assay, caspase-3 activity, and ... more

X.J. Lai; X.Y. Cheng; L.D. Hu
2016 Dec 19
Adult; Aged; Apoptosis; Bone neoplasms; Caspase 8; Cell proliferation; Cell survival; Female; Gene Expression Regulation, Neoplastic; Humans; male; Middle Aged; Osteochondroma; Osteosarcoma; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Young Adult

Osteosarcoma is a common malignant bone tumor that mainly affects children and adolescents. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor superfamily. Caspase-8 appears in the upstream of apoptosis signaling pathway among caspases. We investigated TRAIL and caspase-8 levels in osteosarcoma patients to determine their correlation with ... more

X. Ning; X.W. Shang; Y. Zhuang; M. Liu; H. Yang; H. Zhang; M.Z. Huang
2017 Feb 23
Blotting, Western; Cadherins; Cell Movement; Cell proliferation; Cell survival; Female; Gene Expression Regulation, Neoplastic; Hela cells; Humans; MicroRNAs; Neoplasm Metastasis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Long Noncoding; Uterine cervical neoplasms; Vimentin

Cervical cancer is a common female malignancy of global dimensions. MicroRNAs (miRNAs) play crucial roles in the development, differentiation, proliferation, and apoptosis of tumors. The non-coding RNA MALAT1 participates in various physiological processes that are important for proper functioning of the body. Here, we analyzed the expression of miRNA-143 and MALAT1 in HeLa cells to evaluate ... more

L. Zhang; H.E.X.D. Niyazi; H.R. Zhao; X.P. Cao; M.N.S. Abudula; W.J. Ye; S.A. Zhang; R.H.M. Yiming; Y. Zhang; W.P. Su; R. Chen; Y. Ouyang; N. Miao; Y.X. Bao
2017 Jun 29
Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell proliferation; Colorectal neoplasms; Curcumin; Drug Resistance, Neoplasm; Heat-shock proteins; HSP27 Heat-Shock Proteins; Humans; Inhibitor of Apoptosis Proteins; Molecular chaperones; Proto-Oncogene Proteins c-bcl-2; Survivin

Since there are no studies on the reversal of multidrug resistance by curcumin in the human colorectal cancer cell line HCT-8/5-FU, our aim was to search for highly efficient reversal agents and investigate the underlying mechanisms of this reversal. The cytotoxic effects of curcumin and 5-FU on HCT-8 and HCT-8/5-FU cells and the reversal effects of 5-FU in combination with curcumin on HCT-8/5 ... more

Y.X. Fan; P. Abulimiti; H.L. Zhang; Y.K. Zhou; L. Zhu
2017 Jan 23
Apoptosis; Cell Line, Tumor; Cell proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Proto-Oncogene Proteins c-bcl-2; RNA interference; Uterine cervical neoplasms

Cervical carcinoma is a life-threatening illness posing considerable danger to women's health. microRNAs (miRNAs) have been shown to regulate multiple cellular events, including growth and proliferation, and miR-187 is thought to regulate the growth and apoptosis of certain cell types. Our study focused on the influence of miR-187 on the growth, proliferation, and apoptosis of SiHa cervical ... more

C.Y. He; J. Yang
2017 Mar 08
Adaptor Proteins, Signal Transducing; Adult; Aged; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell proliferation; Down-regulation; Female; Genes, Tumor Suppressor; Humans; KB Cells; male; MicroRNAs; Middle Aged; Monomeric GTP-Binding Proteins; Mouth Neoplasms; RNA, Messenger

Ras association domain family member 5 (RASSF5), a member of the Ras association domain family, induces cell apoptosis by phosphorylating FOXO3a, which triggers target gene BIM (pro-apoptotic factor) activation. MiR-214 is overexpressed in oral cancer tissue, indicating its possible involvement in oral cancer pathogenesis. Bioinformatics analysis has revealed a complimentary sequence between ... more

T.K. Li; K. Yin; Z. Chen; Y. Bao; S.X. Zhang
2016 Dec 19
Animals; Cell Line, Tumor; Cell Movement; Cell proliferation; Endoglin; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; MicroRNAs; Neoplasm Invasiveness; Neoplasm Transplantation; Neovascularization, Pathologic; Thyroid Neoplasms

Thyroid cancer is the most common type of endocrine tumor. MicroRNAs (miRNAs) play a critical role in a variety of diseases, especially cancer occurrence and progression. However, the specific mechanism by which miRNAs trigger disease states has not been fully elucidated. This study aims to investigate the role of miR-27a in thyroid cancer cells. A wound healing assay was adopted to examine ... more

Y.L. Wang; W.G. Gong; Q.L. Yuan
02/23/2017
Apoptosis; Blotting, Western; Breast neoplasms; Cell Line, Tumor; Cell Movement; Cell proliferation; Cyclin-Dependent Kinase Inhibitor p21; DNA-Binding Proteins; Down-regulation; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; MCF-7 cells; MicroRNAs; Microscopy, Electron; Neoplasm Invasiveness; Neoplasm Metastasis; Reverse Transcriptase Polymerase Chain Reaction; Transcription factors

Breast cancer, which derives from the epithelium of the mammary glands, is one of the most common cancers diagnosed in women globally. To date, the authors of many studies have reported that the deregulation of microRNAs (miRNAs) plays a crucial role in the occurrence, development, and metastasis of tumors. Here, we discovered that miR-660-5p was upregulated in the breast cancer cell lines ... more

Y. Shen; Y.F. Ye; L.W. Ruan; L. Bao; M.W. Wu; Y. Zhou
2017 Mar 30
3' Untranslated Regions; AC133 Antigen; Apoptosis; Cell cycle; Cell Line, Tumor; Cell Movement; Cell proliferation; Gene Expression Regulation, Neoplastic; Glioma; Humans; MicroRNAs; Nervous System Neoplasms; RNA, Messenger; Transfection

MiR-200b, a member of the microRNA-200 family, has been identified to be capable of suppressing glioma cell growth through targeting CREB1 or CD133. However, whether miR-200b affects the biological behavior (proliferation, invasion, and migration) of glioma cells is poorly understood. The aim of this study was to evaluate the effect of miR-200b on the biological behavior of glioma cells in ... more

C. Zhao; Z.G. Ma; S.L. Mou; Y.X. Yang; Y.H. Zhang; W.C. Yao
2016 Dec 02
Adenocarcinoma; Adult; Carcinoma, Squamous Cell; Cell proliferation; Female; Fibroblast growth factor 1; Fibroblast Growth Factor 2; Gene Expression Regulation, Neoplastic; Hela cells; Humans; Middle Aged; Neoplasm Staging; Prognosis; Uterine cervical neoplasms; Young Adult

Fibroblast growth factors (FGFs) play important roles in angiogenesis, wound healing, embryonic development, and endocrine signaling pathways. Increasingly, recent studies have reported aberrant FGF expression in various malignancies. However, the involvement of FGFs in cervical carcinoma pathogenesis remains unclear. We aimed to investigate expression of acidic (aFGF) and basic FGF (bFGF) in ... more

Q.H. Zhang; P. Xu; Y.X. Lu; H.T. Dou

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