Research Article

Related GMR Articles

09/27/2017
Genome, Plant; Iron; Oryza; Phenotype; Plant Proteins; Stress, Physiological; Transcription factors

Iron (Fe) is an essential microelement for all living organisms playing important roles in several metabolic reactions. Rice (Oryza sativa L.) is commonly cultivated in paddy fields, where Fe goes through a reduction reaction from Fe to Fe. Since Fe is more soluble, it can reach toxic levels inside plant cells, constituting an important target for studies. Here we aimed to verify morphological ... more

V.E. Viana; N. Marini; T. Finatto; I. Ezquer; C. Busanello; R.S.Dos Santos; C. Pegoraro; L. Colombo; C. de Oliveira
05/10/2017
Antibiotics, Antineoplastic; Apoptosis; Bleomycin; Cell line; Endoplasmic Reticulum Chaperone BiP; Endoplasmic reticulum stress; Heat-shock proteins; Human Umbilical Vein Endothelial Cells; Humans; Receptors, G-Protein-Coupled; Transcription Factor CHOP

In this study, we investigated the effects of pingyangmycin (PYM) on the growth inhibition and apoptosis of human umbilical vein endothelial cells (HUVEC). In this study, we aimed to explore the optimal concentration of PYM to induce the apoptosis of HUVEC and to determine its mechanism of action. After treatment of HUVEC with different concentrations of PYM for 24 h, cell counting kit-8 (CCK- ... more

Y.D. Huang; X. Tong; Q. Chen; S.W. Xia; Y. Zhuo; Z.H. Kang; X.Y. Xue
12/23/2016
Alleles; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; DNA-Binding Proteins; Genotype; Humans; Lung Neoplasms; Neoplasm Staging; Polymorphism, Genetic; Treatment outcome; X-ray Repair Cross Complementing Protein 1

Non-small cell lung cancer (NSCLC) is the most common cancer globally. The XRCC1 protein interacts with ligase and poly(ADP-ribose) polymerase to repair cisplatin-induced DNA damage. The authors of previous studies have reported XRCC1 Arg399Gln, Arg280His, and Arg194Trp polymorphisms and advanced NSCLC prognosis, but the results are inconclusive. We investigated the association between ... more

H.F. Liu; J.S. Liu; J.H. Deng; R.R. Wu
2/16/2017
Adolescent; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Cerebellar Neoplasms; Child; Child, Preschool; Gene Expression Regulation, Neoplastic; Hedgehog Proteins; Humans; Infant; Medulloblastoma; Oxides; Signal transduction

Recent innovations in the genomic understanding of medulloblastomas have provided new ways to explore this highly invasive malignant brain cancer arising from the cerebellum. Among the four different medulloblastoma subgroups described to date, the sonic hedgehog (SHH) genetic pathway is the pathway activated in the tumorigenesis of medulloblastoma. SHH-related medulloblastomas are usually of ... more

P.H.S. Klinger; A.F. Andrade; L.E.A. Delsin; R.G.P. Queiroz; C.A. Scrideli; L.G. Tone; E.T. Valera
4/28/2017
Biomarkers, Tumor; Carcinoma, Signet Ring Cell; CDX2 Transcription Factor; Codon; Female; Genes, ras; Humans; male; Middle Aged; Mucins; Mutation; Mutation Rate; Neoplasm Metastasis; Phenotype; Stomach neoplasms

We aimed to analyze gastric signet ring cell (SRC) carcinoma subtypes by investigating gastric and intestinal phenotypic marker expression, and explore the relationship between phenotype and K-ras mutation. Immunohistochemistry was performed on 163 SRC carcinoma patient specimens to detect gastric (MUC1, MUC5AC, and MUC6) and intestinal (MUC2 and CDX2) phenotypic markers, and tumors were ... more

Z.F. Xiong; J. Shi; Z.H. Fu; H.P. Wan; L.X. Tu
05/31/2017
Cell Line, Tumor; Drugs, Chinese Herbal; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Keratinocytes; Panax; Scutellaria; Ultraviolet Rays

Hypoxia-inducible factor-1α (HIF-1α) is considered the main transcriptional regulator of the hypoxia-specific cellular and developmental response. This study was performed to investigate the effect of Shenqin biochemical extract (SQBE) on HIF-1α expression in ultraviolet B (UVB)-irradiated HaCaT cells and the possible action mechanisms of SQBE against UVB-induced skin cancer. HaCaT cells in ... more

X. Chen; J. Bai; Y. Li; X.G. Li; G.F. Lv; H.C. Zhang
2017 Jun 20
Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Cell Adhesion Molecules; Female; Gene Expression Regulation, Neoplastic; Humans; Kalinin; Lung Neoplasms; male; Microfilament Proteins; Neoplasm Recurrence, Local

Lung cancer is the leading cause of cancer death in men and the second leading cause of cancer death in women worldwide. Fascin-1 and laminin-5 were associated with the invasiveness and prognoses of several cancers. The expression and the serum levels of fascin-1 and laminin-5 in patients with non-small cell lung cancer (NSCLC) were analyzed in this study. The expression of fascin-1 and ... more

L. Yang; Y. Teng; T.P. Han; F.G. Li; W.T. Yue; Z.T. Wang
03/18/2016
Breast neoplasms; Chemotherapy; DNA damage; Germline micronucleus; Sister chromatid exchange

The aim of the present study was to investigate DNA damage in peripheral blood lymphocytes of breast cancer (BC) patients before and after administration of chemotherapy. We analyzed the frequency of sister chromatid exchange (SCE), occurrence of micronuclei (MN), and lymphocyte proliferation rate index (PRI) as cytogenetic markers in 28 female BC patients before and after chemotherapy, ... more

P.A. Koşar; M. Koçer; D.A. Çelik; N. Ozcelik; P.A. Koşar; M. Koçer; D.A. Çelik; N. Ozcelik; P.A. Koşar; M. Koçer; D.A. Çelik; N. Ozcelik
08/29/2016
Cell cycle; Cell proliferation; Gastric cancer; Kallikrein 12; Small interfering RNA

Abnormal expression of the kallikrein (KLK) family of serine proteases closely correlates with onset, progression, and prognosis of endocrine gland-related malignant tumors. The aim of this study was to evaluate how downregulation of KLK12 influenced cell cycle and proliferation of the AGS gastric cancer cell line. KLK12 was detected by western blot in GES-1 normal gastric ... more

X.S. Li; X.L. He; X.S. Li; X.L. He
11/03/2016
Adipose-derived stem cell; Cell apoptosis; Cell proliferation; Histone acetylation; Stem cell multipotency

Adipose-derived stem cells (ADSCs) show nearly unlimited potential in medical and animal science. Currently, understanding of the biological mechanisms regulating ADSC growth in vitro remains very limited. Histone acetylation, an epigenetic modification, plays a key role in maintaining stem cell properties. To further study its effect on ADSC growth ... more

X. Wang; F.X. Zhang; Z.M. Wang; Q. Wang; H.F. Wang; Y. Ren; D.P. Tai; H. Liang; D.J. Liu; X. Wang; F.X. Zhang; Z.M. Wang; Q. Wang; H.F. Wang; Y. Ren; D.P. Tai; H. Liang; D.J. Liu

Pages