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Related GMR Articles

06/11/2010
Biomonitoring; Chromosome aberration; Indoor exposure; Micronucleus; Petroleum exposure

We looked for genotoxic effects in laboratory personnel routinely exposed to petroleum derivate compounds in an indoor environment. The exposed group of 21 workers from the Fuel Quality Control Laboratory of the Brazilian Petroleum Agency was matched with a group of 10 people from the staff of the Brazilian Ministry of Health. Chromosome aberrations in peripheral blood lymphocytes, ... more

A.E.O. Araújo; B.P. Mezzomo; I. Ferrari; C.K. Grisolia
02/09/2010
Aspergillus nidulans; Diuron; Genotoxic agents; Herbicides; mitotic crossing-over; Trifluralin

Some herbicides are suspected of promoting teratogenic, carcinogenic and mutagenic events. Detection of induced mitotic crossing-over has proven to be an indirect way of testing the carcinogenic properties of suspicious substances, because mitotic crossing-over is involved in the multistep process of carcinogenesis. We examined mitotic crossing-over induced by two commercial herbicides ( ... more

R.A. Cardoso; L.T.A. Pires; T.D. Zucchi; F.D. Zucchi; T.M.A.D. Zucchi
12/30/2002
EMS; Ethyl methyl sulfonate; Gamma radiation; Glufosinate; Herbicide resistance; Mutagenesis; Rice; Segregation

Over the last two decades, mutational techniques have become one of the most important tools available to progressive rice- breeding programs. In a mutation-breeding program initiated in 1999 at the Instituto Agronômico of Campinas, SP, Brazil, a rice line, IAC103, was selected for mutational studies with gamma radiation and ethyl methyl sulfonate mutagenesis, with the aim of ... more

S.S. Sandhu; C.R. Bastos; L.Ernesto Azini; A.Tulmann Neto; C. Colombo
06/30/2003
Canova Method; Cytogenetics; Mitotic index; Mutagenesis

The Canova Methodâ (CM) is a homeopathic medicine indicated for the treatment of patients with cancer and for pathologies that involve a depressed immune system, such as AIDS. This product is composed of homeopathic dilutions of Aconitum napellus, Arsenicum album (arsenic trioxide), Bryonia alba, Lachesis muta venom and Thuya ... more

I.C. Seligmann; P.D.L. Lima; P.C.S. Cardoso; A.S. Khayat; M.O. Bahia; Dde Freitas Buchi; I.R. Cabral; R.R. Burbano
07/29/2008
Comet assay; Micronucleus test; Mutagenesis; Psidium cattleyanum; Single-cell gel electrophoresis

Cattley guava (Psidium cattleyanum Sabine) is a native fruit of Brazil that is popular both as a sweet food and for its reputed therapeutic properties. We examined whether it could damage DNA using the alkaline single-cell gel electrophoresis (comet assay) and the micronucleus test in leukocytes and in bone marrow cells of mice. P. cattleyanum leaf extract was tested at ... more

T.D.A. Costa; S. Vieira; S.F. Andrade; E.L. Maistro
07/24/2014
Inter-simple sequence repeat; Molecular marker; Mutagenesis; Orchid; Tissue culture

In vitro mutagenesis of Dendrobium ‘Earsakul’ was carried out by incubating the protocorm-like bodies in 0-5 mM sodium azide for 1 h. Twenty-eight putative mutants were evaluated for genetic variability compared to untreated control plants using inter-simple sequence repeat (ISSR) analysis. Polymorphic fragments were produced by 9 of 12 ISSR primers. A total of 173 ... more

A. Wannajindaporn; O. Poolsawat; W. Chaowiset; P.A. Tantasawat
07/07/2014
Comet assay; Cordia ecalyculata; Micronucleus; Mutagenesis; Spirulina maxima

Obesity is one of the most important nutritional disorders, and can be currently considered as an epidemic. Although there are few weight reduction drugs available on the market, some new drug candidates have been proposed, including Cordia ecalyculata, a Brazilian plant with anorectic properties, and Spirulina maxima, a cyanobacterium with antioxidant and anti-genotoxic ... more

R.P. Araldi; B.M. Rechiutti; T.B. Mendes; E.T. Ito; E.B. Souza
12/30/2003
Comet assay; Micronucleus test; Occupational exposure

The micronucleus (MN) test and the alkaline single cell gel or comet assay were applied to exfoliated cells of the buccal mucous in order to evaluate the genotoxic risk associated with occupational exposure of 10 storage battery renovation workers, and 10 car painters, with age matched controls, in Pelotas, RS, in southern Brazil. In the MN test, 2000 exfoliated buccal cells were ... more

M.G. Martino-Roth; J. Viégas; D.M. Roth
03/09/2006
Biological monitoring; Exfoliated cells; Gas station attendants; Micronucleus test; Mutagenicity; Occupational exposure

In the present study, the micronucleus test was applied in exfoliated cells of buccal mucosa to assess the mutagenicity risk associated with occupational exposure for gas station attendants. For each individual, 2000 exfoliated buccal cells were analyzed for micronucleus frequency. A highly significant difference was found between exposed and control groups. Likewise, a significant ... more

C.Iribarrem Benites; L.Lund Amado; R.Aloma Pack Vianna; Mda Graça Martino-Roth
05/21/2012
Ageing; Comet assay; GST genes; Micronucleus test; Multiplex PCR; Occupational exposure

We evaluated the possible influence of glutathione S-transferase mu (GSTM1) and glutathione S-transferase theta (GSTT1) genes on genetic damage due to occupational exposure, which contributes to accelerate ageing. This study was conducted on 120 car auto repair workshop workers exposed to occupational hazards and 120 controls without this kind of exposure. The null and non-null genotypes ... more

S.A. Eshkoor; S.J. Marashi; P. Ismail; S.A. Rahman; M. Mirinargesi; M.Y. Adon; R.V. Devan

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