Research Article

Related GMR Articles

11/17/2009
Bos indicus; Leptin; Linkage disequilibrium; Markers; UCP1

The association between two single nucleotide polymorphisms (SNPs), T945M and UCP1SNP1, with hot carcass weight (HCW, kg, N = 618), longissimus dorsi muscle area (REA, cm2, N = 633), and backfat thickness (BF, mm, N = 625), measured in Nellore cattle in Brazil, was evaluated. Likelihood ratio tests were used to evaluate reduced (fixed effects of general mean, contemporary ... more

J.B.S. Ferraz; L.F.B. Pinto; F.V. Meirelles; J.P. Eler; F.M. de Rezende; E.C.M. Oliveira; H.B. Almeida; B. Woodward; D. Nkrumah
11/02/2008
Leptin; obese gene; Polymerase chain reaction; Quantitative trait loci; Restriction fragment length polymorphism

The aim of the present study was to identify polymorphisms in the leptin gene of 112 pigs and compare the maternal and paternal lineage of Pietrain and Large White breeds that underwent a divergent selection for over 30 years. DNA samples extracted from the blood of these animals were amplified by polymerase chain reaction and genotyped by restriction fragment length polymorphism ... more

A.C.P. Silveira; R.C. Antunes; J.F. Almeida; T.F. Braga; P.F.A. Freitas; A.S.M. César; A.S.M. César; E.C. Guimarães
06/07/2011
BMI; Leptin; MC4R gene; Obesity

Mutations in the melanocortin-4 receptor (MC4R) are associated with severe obesity, independent of their effect on cortisol or thyroid-stimulating hormone levels. We examined a morbidly obese male (BMI = 62 kg/m2) with a binge-eating disorder and eight family members for mutations in the MC4R gene and potential differences in leptin levels. Fifty healthy individuals served as ... more

S. Buchbinder; U. Bärtsch; M. Müller; M. Zorn; P.P. Nawroth; T. Schilling
07/15/2013
Leptin; Leptin receptor; Polymorphism; Preeclampsia

The aim of this study was to investigate the relationship between the leptin receptor (LEPR) polymorphism/serum leptin level and preeclampsia. The prevalence of a single nucleotide polymorphism in the LEPR gene exon 14 at -656 and the serum leptin concentrations in 97 preeclamptic pregnant mothers were compared to those of 110 healthy controls. The Lys656Asn genotype and ... more

S. Wang; F.Y. Qiao; L. Feng
10/11/2012
Beef cattle; Bos indicus; Leptin; Molecular markers; Ultrasound traits

Given the important role of leptin in metabolism, we looked for a possible association of leptin and leptin receptor polymorphisms with carcass and growth traits in Nellore cattle. We examined associations of leptin and leptin receptor SNPs with ultrasound carcass (longissimus dorsi muscle area (ribeye area), backfat thickness and rump fat thickness and growth traits (weaning weight ... more

R.C.G. da Silva; J.B.S. Ferraz; F.V. Meirelles; J.P. Eler; J.C.C. Balieiro; D.C. Cucco; E.C. Mattos; F.M. Rezende; S.L. Silva
02/14/2014
Gene expression; Leptin; Leptin receptor; Swine

Leptin is an important regulator of appetite, energy metabolism, and reproduction and is mainly synthesized in the adipocytes and then secreted into the bloodstream. The leptin receptor was classified as type I cytokine receptor due to its structural homology with IL-6 receptors and the signaling pathways in which they are both involved. The aim of our study is to comparatively assess the ... more

S.E. Georgescu; M.A. Manea; S. Dinescu; M. Costache
04/12/2011
Lactation; Mouse; Pregnancy; PrRP

We compared levels of prolactin-releasing peptide (PrRP) mRNA expression in mouse medulla at different stages of pregnancy and lactation. Mouse medulla samples were collected on days 6, 12 and 18 of pregnancy and lactation, respectively (six per group), for mRNA. Expression levels of PrRP mRNA in the medulla were measured by semi-quantitative RT-PCR, with glyceraldehyde 3-phosphate ... more

H.S. Zhu; J.X. Du; Y.Y. Wang; L.F. Wang; L.Q. Hang; G.Y. Yang; Y.L. Wang
12/21/2012
IL-8; Lactation; Mammary gland; Mouse; Pregnancy

Interkeukin-8 (IL-8) is an important inflammatory mediator. It is an angiogenic factor associated with inflammation and carcinogenesis. To date, research on IL-8 has been limited to its role as an indicator of inflammation. There has been no systematic research concerning IL-8 expression levels in the mouse mammary gland during pregnancy and lactation. Mouse mammary gland samples were ... more

H.P. Li; Y.J. Guo; H.S. Zhu; K. Zhong; G.M. Zha; L.F. Wang; Y.L. Wang; W.F. Lu; Y.Y. Wang; G.Y. Yang
07/02/2014
Lactation; Lactoferrin; Mammary gland; Mouse; Pregnancy

Lactoferrin (Lf) is an iron-binding glycoprotein that is produced by mucosal epithelial cells in mammals. Lf has non-immune natural defense functions and biological functions in addition to and distinct from its role in regulating inflammatory responses. Lf also improved some physiological and immunological parameters. Lf is a biomarker for monitoring medical treatment in inflammatory ... more

H.P. Li; X.L. Jiao; X.J. Wang; F.T. Liu; H.S. Zhu; Y.Y. Wang; G.Y. Yang
10/05/2007
Genetic polymorphism; Leptin; Leptin receptor; Obesity; β3-adrenergic receptor

Obesity is due to the combined effects of genes, environment, lifestyle, and the interactions of these factors. The adrenergic receptor β3 (β3-AR), leptin (LEP) and leptin receptor (LEPR) genes have been intensively evaluated in the search of variants that could be related to obesity and its cardiometabolic complications. The results of most of these studies have ... more

S.F.P. Duarte; E.A. Francischetti; V.A. Genelhu; P.H. Cabello; M.M.G. Pimentel

Pages