Research Article

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Gastric cancer (GC) is a prevalent disease with a high mortality rate, especially in developing countries. Accumulating evidence suggests that single nucleotide polymorphisms in microRNA (miRNA) genes might influence the susceptibility to GC; such sequence variation might contribute to the development of disease by altering crucial cellular pathways. In this study, we assessed the ... more

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Helicobacter pylori is a gram-negative, microaerophilic bacterium and an etiological agent of gastroduodenal diseases, including gastritis, peptic ulcers, mucosa-associated lymphoid tissue lymphoma, and gastric cancer. H. pylori affects approximately half of the global population. Most infected patients remain asymptomatic or exhibit non-severe ... more

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Sex reversal due to duplication of the Xp21 dosage-sensitive sex reversal locus results in XY females with gonadal dysgenesis. Pure Xp disomy (without a concurrent loss of genetic material) can occur by translocation or interstitial duplication. The case reported here is the rare form with a t(Xp;Yp). The combination of conventional clinical cytogenetic techniques, microsatellite analysis and ... more

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Bioanalyzer; DNase treatment; Microarray; Preimplantation murine embryos; RNA extraction; RT-qPCR

The quality of RNA is crucial when performing microarray experiments. This is particularly important when dealing with preimplantation embryos, from which a minimum yield of RNA of good quality can be produced. We report the optimization of several RNA extraction methods applied to preimplantation embryos at different stages of development. The quality of the samples was confirmed using a ... more

J. Norhazlin; M.N.K. Nor-Ashikin; B.P. Hoh; S.H.Sheikh Abd Kadir; S. Norita; M. Mohd-Fazirul; W.J. Wan-Hafizah; D. Razif; M.H. Rajikin; B. Abdullah
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Mitochondria are closely associated with cell survival, and it is of interest to determine whether apoptosis pathways, which are mediated by mitochondria, are involved in liver regeneration (LR). To identify the mechanisms underlying mitochondria-mediated apoptosis during rat LR, we used the Rat Genome 230 2.0 Array to investigate changes in gene expression. Next, we searched the GO and ... more

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Biochemical analysis; Microarray; Mutant; Oryza sativa; Salt tolerance

Salinity is a major environmental stress to plants. In this study, the ability of plants to tolerate salt was investigated by studying growth, physiological characteristics, and expression levels of genes related to the salt-stress response in the salt-tolerant rice mutant (Till-II-877), which was derived from γ-ray irradiation. Compared to plants grown under ... more

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Cardiotoxicity; Celecoxib; Diclofenac; EC decoupling; Microarray; NSAIDs

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely-used medications for the treatment of many inflammatory diseases. . They inhibit cyclooxygenase (COX) enzymes as a primary mechanism of action. However, many of these drugs were withdrawn from the market because of cardiovascular side effects. To date, only a limited number of genes and specific gene ... more

C.K. Oh; M.S.F. Ahmed; C. Xie; J.H. Ryu; J. Choi; J.S. Chung; G.S. Roh; H.J. Kim; G.J. Cho; W.S. Choi; S.S. Kang; D.H. Lee
03/18/2016
Genome sequencing; Genome-scale metabolic model; Lipase-producing strain; Systems biology

Lipase-producing bacteria are naturally-occurring, industrially-relevant microorganisms that produce lipases, which can be used to synthesize biodiesel from waste oils. The efficiency of lipase expression varies between various microbial strains. Therefore, strains that can produce lipases with high efficiency must be screened, and the conditions of lipase metabolism and optimization of ... more

N. Li; D.D. Li; Y.Z. Zhang; Y.Z. Yuan; H. Geng; L. Xiong; D.L. Liu; N. Li; D.D. Li; Y.Z. Zhang; Y.Z. Yuan; H. Geng; L. Xiong; D.L. Liu; N. Li; D.D. Li; Y.Z. Zhang; Y.Z. Yuan; H. Geng; L. Xiong; D.L. Liu
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Gastric cancer; Invasion; miR-221; Proliferation; Propofol

Propofol is one of the extensively and commonly used intravenous anesthetic agents. The current study aimed to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms of this activity. The effects of propofol on SGC7901 and AGS cell proliferation, apoptosis, and invasion were detected by MTT assay, flow cytometric analysis, and matrigel ... more

Z.T. Wang; H.Y. Gong; F. Zheng; D.J. Liu; X.Q. Yue
12/21/2015
Clinical outcome; ERCC1; ERCC2; Gastric cancer; Polymorphism

We performed a study to investigate the role of ERCC1 (rs11615, rs2298881, and rs3212986) and ERCC2 (rs13181, rs238406, and rs1799793) polymorphisms in the prognosis of gastric cancer. A total of 346 patients with gastric cancer were recruited between May 2009 and May 2012. Single nucleotide polymorphism genotyping was performed using the Sequenom MassARRAY platform. The GA+ ... more

W.H. Yu; Y.X. Wang; J.Q. Guo; Y.L. Wang; J.S. Zheng; K.X. Zhu

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