Research Article

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10/19/2010
Antioxidant; Lipid metabolism genes; Oxidative stress; Thai black sticky rice

Anthocyanins, which are found in some food, including Thai black sticky rice, are reported to have health-promoting properties. Oxidative stress plays a major role in the pathogenesis of many degenerative diseases induced by free radicals, such as cardiovascular disease, stroke and cancer. We evaluated the anthocyanin-rich extract (ARE) from Thai black sticky rice for antioxidative and ... more

W. Sangkitikomol; T. Tencomnao; A. Rocejanasaroj
06/13/2013
Mitochondrial plasmid; Moniliophthora perniciosa; Oxidative stress; Polymerases

Moniliophthora perniciosa (Stahel) Aime and Phillips-Mora is a hemibiotrophic basidiomycete (Agaricales, Tricholomataceae) that causes witches’ broom disease in cocoa (Theobroma cacao L.). This pathogen carries a stable integrated invertron-type linear plasmid in its mi­tochondrial genome that encodes viral-like DNA and RNA polymerases re­lated to fungal senescence and ... more

B.S. Andrade; C. Villela-Dias; D.S. Gomes; F. Micheli; A. Góes-Neto
04/28/2015
Cyclophilin-D protein; Endothelial cells; Oxidative stress

We examined the influence of cyclophilin-D (CypD) protein expression level on endothelial cell oxidative damage resistance. A model of CypD protein expression or high expression in endothelial cells was established through gene silencing or cloning. The comparable groups were normal endothelial cells cultured in phosphate-buffered solution in liquid handling cells containing 500 mM H ... more

J.Z. Peng; L. Xue; J. Chen; B.S. Chen; Y.Q. Yang
03/30/2015
3-NPA; Ovary; Oxidative stress; Proanthocyanidins

Oxidative stress, which poses a threat to reproductive health, causes many serious female reproductive diseases. In this study, we investigated whether proanthocyanidins (PC) have a protective effect against oxidative stress-induced ovarian damage. Forty female ICR mice were randomized into 4 groups: a control group, a control plus PC group, a 3-nitropropionic acid (3-NPA) group, and a 3- ... more

J.Q. Zhang; B.S. Xing; C.C. Zhu; M. Shen; F.X. Yu; H.L. Liu
03/20/2015
Corynebacterium glutamicum; Oxidative stress; Peptide methionine sulfoxide reductase; Superoxide dismutase

Promoters of genes encoding superoxide dismutase (sodA) and peptide methionine sulfoxide reductase (msrA) from Cory­nebacterium glutamicum were cloned and sequenced. Promoter region analysis of sodA-msrA was unable to identify putative sites of fixed eventual regulators except for possible sites of fixed OxyR and integra­tion host factor. A study of the ... more

H.M.El Shafey; S. Ghanem
12/21/2005
Breast cancer; Polymorphisms; RAD51-G135C; XPD-Lys751Gln; XRCC1-Arg399Gln; XRCC3-Thr241Met

Several studies have reported that the genes involved in DNA repair and in the maintenance of genome integrity play a crucial role in protecting against mutations that lead to cancer. Epidemiologic evidence has shown that the inheritance of genetic variants at one or more loci results in a reduced DNA repair capacity and in an increased risk of cancer. Polymorphisms have been ... more

R.Mucha Dufloth; S. Costa; F. Schmitt; L.Carlos Zeferino
04/13/2005
DNA; Minisequencing; Multiplex; Polymorphisms; Single nucleotide polymorphisms

Several technologically sophisticated high-throughput techniques have been recently developed for the study of human single nucleotide polymorphisms and the diagnosis of point mutations in human diseases. However, there is also a need for simple and inexpensive techniques suitable for clinical services and small research laboratories. Minisequencing meets the latter requirements. It is ... more

C.M.B. Carvalho; S.D.J. Pena
12/01/2009
Childhood acute lymphoblastic leukemia; Haplotypes; Mexicans; Polymorphisms; XRCC1

We examined the influence of the Arg194Trp, Arg280His, and Arg399Gln polymorphisms of XRCC1 (X-ray repair cross-complementing group 1) on the development of childhood acute lymphoblastic leukemia (ALL) in 120 ALL patients and 120 controls in Mexico. All of them were genotyped for these polymorphisms, using polymerase chain reaction. No significant differences in allele and ... more

J.P. Meza-Espinoza; V. Peralta-Leal; M. Gutierrez-Angulo; N. Macias-Gomez; M.L. Ayala-Madrigal; P. Barros-Nuñez; J. Duran-Gonzalez; E. Leal-Ugarte
07/01/2008
Breast cancer; estrogen; Hereditary disease; Polymorphisms

The association of tumor differentiation and estrogen receptor expression with the prognosis of breast cancer has been well established. Nevertheless, little is yet reported about the association of morphological characteristics of the tumor, estrogen receptor status and polymorphisms in low penetrance genes. The aim of the present study was to investigate a possible association between DNA ... more

R.M. Dufloth; A. Arruda; J.K.R. Heinrich; F. Schmitt; L.C. Zeferino

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