Research Article

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12/21/2012
Polymorphisms; Recurrent pregnancy loss; VEGF

Vascular endothelial growth factor (VEGF) regulates endothelial cell proliferation, migration and differentiation. VEGF plays a critical role in angiogenesis during placenta formation. We investigated whether VEGF gene polymorphisms are associated with recurrent pregnancy loss. Thirty-eight women with recurrent pregnancy loss and 30 control women with live-born children were recruited ... more

H. Şamlı; B.Ç. Demir; A. Özgöz; M.A. Atalay; G. Uncu
12/03/2012
Bos indicus; Insulin-like growth factor; Polymorphisms; Yearling weight

Meat quality is an important trait for the beef industry. Backfat thickness, ribeye area, and shear force are traits measured late in life, and the investigation of molecular markers associated with these traits can help breeding programs. In cattle, some polymorphisms have been related to production traits. Thus, the purpose of this study was to assess the presence of polymorphisms in ... more

P.C. Tizioto; S.L. Meirelles; R.R. Tulio; A.N. Rosa; M.M. Alencar; S.R. Medeiros; F. Siqueira; G.L.D. Feijó; L.O.C. Silva; R.A.A.Torres Júnior; L.C.A. Regitano
10/04/2012
Glioma risk; MDM2; Meta-analysis; p53; Polymorphisms

Epidemiological studies of the association of variants p53 Arg72Pro and MDM2 single-nucleotide polymorphism 309 (SNP309) with glioma risk have produced inconsistent results. The aim of the current study was to evaluate the association of these 2 variants with glioma susceptibility using a meta-analysis approach. For p53 Arg72Pro, 10 case-control studies including ... more

J.N. Zhang; S.H. Yi; X.H. Zhang; X.Y. Liu; Q. Mao; S.Q. Li; W.H. Xiong; Y.M. Qiu; T. Chen; J.W. Ge
09/26/2012
Arg904Gln; Essential hypertension; Meta-analysis; Polymorphisms; TSC

Although there have been several studies investigating a possible association between essential hypertension and TSC gene Arg904Gln polymorphisms, the results have been inconsistent. We conducted a meta-analysis of four case-control studies (one study in Europe and three studies in Asia), including 1811 essential hypertension cases and 1381 controls. The pooled results showed no ... more

F. Zhang; Y. Yang; D. Hu; H. Lei; Y. Wang
08/16/2012
Han population genetics; HLA; Polymorphisms; STR

A large number of microsatellite genetic markers have been identified in the human leukocyte antigen (HLA) region. We investigated genetic polymorphism of the nine short tandem repeat (STR) loci (D6S276, MOGCA, D6S265, MIB, D6S273, G51152, TAP1CA, RING3CA, and D6S291) in the HLA region in the Shaanxi Han population. Using a fluorescence-labeled multiplex-PCR STR typing method, 6-13 ... more

H.B. Zhang; S.G. Wei; B. Yu; L. Li; J.H. Lai
05/09/2012
Cervical spondylotic myelopathy; Collagen IX; Polymorphisms; Smoking

We investigated a possible association of collagen IX tryptophan (Trp) alleles (Trp2 and Trp3) and smoking with cervical spondylotic myelopathy (CSM) in 172 Chinese patients and 176 age- and gender-matched controls. The smoking status was evaluated by smoking index (SI). The CSM cases had a significantly higher prevalence of Trp2 alleles (Trp2+) than controls (19.8 vs 6.2%, P = 0 ... more

Z.C. Wang; J.G. Shi; X.S. Chen; G.H. Xu; L.J. Li; L.S. Jia
12/04/2014
Ethnicity; Fat mass- and obesity-associated; Polymorphisms; Solute carrier family 30 member 8; Type 2 diabetes mellitus

Recent genome wide association studies identified many loci in several genes that have been consistently associated with type 2 diabetes mellitus in various ethnic populations. Among the genes that were most strongly associated with diabetes were fat mass- and obesity-associated, melanocortin 4 receptor, solute carrier family 30 member 8 (SLC30A8), and a member of the potassium voltage- ... more

M.D. Bazzi; F.A. Nasr; M.S. Alanazi; A. Alamri; A.A. Turjoman; A.S. Moustafa; A.A. Alfadda; A.A.K. Pathan; N.R. Parine
01/24/2014
Folate intake; Gastric cancer; Methylenetetrahydrofolate reductase; Polymorphisms

Folic acid and methylenetetrahydrofolate reductase (MTHFR) may both affect the development of human cancer. We conducted a population-based case-control study in a Chinese population to investigate the potential role of folate intake and MTHFR gene polymorphisms in gastric cancer, and their interaction with infection by Helicobacter pylori and tumor location. A total of ... more

J. Chen; L. Yuan; Y.Q. Duan; J.Q. Jiang; R. Zhang; Z.J. Huang; X.R. Xiao
10/27/2014
Glutamate receptor; Heroin addiction; Ionotropic; N-methyl D-aspartate 2A; Polymorphisms

Heroin dependence is a debilitating psychiatric disorder with a complex inheritance mechanism. Genetic polymorphisms in functional regions of the glutamate receptor, N-methyl D-aspartate 2A (GRIN2A) gene, which encodes the 2A subunit of the N-methyl D-aspartate (NMDA) receptor, may modulate the risk of heroin addiction. We investigated the potential association between 8 single ... more

H.J. Zhong; Z.H. Huo; J. Dang; J. Chen; Y.S. Zhu; J.H. Liu
10/20/2014
Polymorphisms; Serotonin; Tobacco smoking

Previous studies have revealed a genetic component, including genetic polymorphisms in the serotonergic pathway, particularly in the serotonin receptor gene (5-HT2A). The aim of this study was to investigate associations of the T102C (rs6313) and A-1438G (rs6311) polymorphisms with tobacco use in a population from northeastern Brazil. We evaluated these polymorphisms in 135 ... more

E.S.Ramos Neto; J.O. Mágulas; J.J.S. Sousa; A.C.M. Moura; G.R. Pinto; F.K.N. Yoshioka; R. Canalle; F.J.N. Motta

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