Research Article

Related GMR Articles

03/24/2014
DLK2 gene; Growth and meat traits; Mutation; Polymorphisms; Qinchuan cattle

The delta-like 2 homolog (DLK2) modulates adipogenesis, hematopoiesis, osteogenesis, and other cell-differentiation processes. In the present study, we detected potential polymorphisms in the DLK2 gene in 604 individuals of Qinchuan cattle by using PCR-RFLP and DNA-sequencing methods. Herein, we identified five novel single-nucleotide polymorphisms (SNPs) (g.888G>A, g.910A> ... more

N. Yang; L.S. Zan; Y.K. Li; J.B. Gao; X.H. Ma; C.Z. Fu; H. Wang; C. Adoligbe
03/17/2014
Down syndrome; Folate; MTHFD; Polymorphisms; Transcobalamin gene

We examined whether polymorphisms in the methylenetetrahydrofolate dehydrogenase (MTHFD) and transcobalamin (TC) genes, which are involved in folate metabolism, affect maternal risk for Down syndrome. We investigated 76 Down syndrome mothers and 115 control mothers from Bengbu, China. Genomic DNA was isolated from the peripheral lymphocytes. Polymerase chain reaction and ... more

Y.P. Liao; D. Zhang; W. Zhou; F.M. Meng; M.S. Bao; P. Xiang; C.Q. Liu
02/28/2014
Asthma; IL-4; Meta-analysis; Polymorphisms; Promoter

This study aimed to more precisely assess the correlation between interleukin-4 (IL-4) promoter polymorphisms and the susceptibility risk of asthma. We conducted association studies on IL-4 promoter C-33T, C-589T, and G-1098T polymorphisms with asthma using data obtained from MEDLINE up to September 2011. Results showed that the polymorphisms IL-4 C-33T and C-589T were significantly ... more

L. Tang; H.G. Lin; B.F. Chen
06/12/2015
Chinese raccoon dog; Coat color; EDNRB gene; KIT gene; Polymorphisms

The Chinese raccoon dog (Nyctereutes procyonoides procyonoides) is one of the most important fur-bearing animal species. The dominant white individual, a coat color variant in farmed Chinese raccoon dog, shows a completely white phenotype over the entire body. The KIT and EDNRB genes have been reported to be associated with the dominant white coat color in some ... more

S.Q. Yan; C.Y. Bai; S.M. Qi; M.L. Li; S. Si; Y.M. Li; J.H. Sun
06/11/2015
Breast cancer; Ethnicity; Glutathione S-transferases; Northeastern Mexico; Polymorphisms

Glutathione S-transferases (GSTs) are a family of phase II metabolizing enzymes involved in carcinogen detoxification and the metabolism of various bioactive compounds. Several genes that code for these enzymes are polymorphic in an ethnicity-dependent manner, with particular genotypes previously associated with an increased risk of breast cancer. The purpose of this study was to ... more

G. Jaramillo-Rangel; M. Ortega-Martínez; R.M. Cerda-Flores; H.A. Barrera-Saldaña
06/12/2015
Molecular epidemiology; Osteoprotegerin; Polymorphisms; Rheumatoid arthritis

In order to investigate the association between osteoprotegerin (OPG) gene polymorphisms and rheumatoid arthritis (RA), we studied OPG rs3102735 T/C and rs2073618 G/C polymorphisms in a Chinese Han population comprising 574 patients with RA and 804 controls. Genotyping by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was conducted. Our data ... more

X.H. Ye; J.L. Cheng; R.P. Liu
05/11/2015
Meat quality traits; Polymorphisms; Qinchuan cattle

Here, we detected 2 SNPs, A85C and T335C, that were located on the 3rd exon and the 3 untranslated regions of the bovine Osteocrin gene, respectively, using 413 Qinchuan cattle DNA samples. PCR-SSCP and DNA sequencing methods were specifically used. Three genotypes (AA, AC, and CC) were found at A85C; yet, only 2 genotypes (TC and CC) were found at T335C. Association analysis showed that ... more

Y.F. Huangfu; L.S. Zan; C. Adoligbe; H.B. Wang; H. Wang; J.B. Gao
04/13/2015
Ethnic; Infectious disease; Interleukin-10; Interleukin-12B; Malaysia; Polymorphisms

Inheritance of polymorphisms in the interleukin (IL)-10 promoter and IL-12B genes, which influence cytokine production and activities, may define the balance in T helper response in infection and autoimmune diseases. In the present study, we investigated the distribution of the IL-10 promoter and IL-12B gene polymorphisms in a multiethnic Malaysian population. Overall, ... more

S.S. Sam; B.T. Teoh; S. AbuBakar
04/10/2015
Breeding; Hybrid rice; Indels; Polymorphisms; Single nucleotide polymorphisms

Genome-wide re-sequencing of the Zhenshan 97 (ZS97) and Milyang 46 (MY46) parents of an elite three-line hybrid rice developed in China resulted in the generation of 9.91 G bases of data with an effective sequencing depth of 11.66x and 11.51x, respectively. Detection of genome-wide DNA polymorphisms, single nucleotide polymorphisms (SNPs), short insertions/deletions (InDels; 1-5 bp), and ... more

K. Wang; J.Y. Zhuang; D.R. Huang; J.Z. Ying; Y.Y. Fan
03/31/2015
Amerindian; Ethnicity; Mexican Mestizo population; MMP-9; Polymorphisms; Population genetics

We studied the interethnic variation of the MMP-9 microsatellite in the Mestizo and Amerindian populations using blood samples collected from 435 healthy unrelated individuals from the Central Valley of Mexico. DNA samples were genotyped using the -90 (CA)12-27 repeat near the MMP transcriptional start site using capillary electrophoresis. Our data were ... more

R. Camacho-Mejorado; G. Noris; C. Santana; J.J. Magaña; A. Majluf-Cruz; J. Arellano-Galindo; A. De la Peña; J. Hernández-Juárez; E.S. Calderón-Aranda; M.A. Meraz-Ríos; R. Gómez

Pages