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Related GMR Articles

05/16/2014
Glioma; Polymorphisms; Xeroderma pigmentosum complementation group F

We aimed to investigate the role of 4 single nucleotide polymorphisms of the xeroderma pigmentosum complementation group F (XPF) gene (rs3136038, rs1799798, rs1800067, and rs2276466) in glioma, and the roles of gene-gene interactions in the risk of developing this type of cancer. We collected samples from 225 glioma cases and 262 controls and genotyped the rs3136038, rs1799798, rs1800067 ... more

W.K. Zhou; L.Y. Huang; L. Hui; Z.W. Wang; B.Z. Jin; X.L. Zhao; X.Z. Zhang; J.X. Wang; J.C. Wang; R.Z. Wang
05/09/2014
Acute myeloid leukemia; Glutathione S-transferase; Polymorphisms

We aimed to investigate the relationships between polymorphisms of the glutathione S-transferases (GSTs) GSTM1, GSTTI, and GSTP1 and the risk of developing acute myeloid leukemia (AML). A total of 206 AML cases and 231 controls were collected for our study. The genotyping of GSTs (GSTM1, GSTTI, and GSTP1) was based upon the duplex ... more

Y.M. Zi; S. Wu; D. Ma; C. Yang; M. Yang; Y. Huang; S.J. Yang
02/14/2014
Colorectal cancer; Mexican population; MMP13; MMP7; Polymorphisms

Colorectal cancer (CRC) is characterized by enhanced expression and activity of several metalloproteinases (MMPs), including MMP13 and MMP7, which play an important role in tumor invasion and metastasis. The objective of this study was to analyze the association of functional MMP7-181A/G and MMP13-77A/G promoter polymorphisms with susceptibility to CRC ... more

J.M. Moreno-Ortiz; M. Gutierrez-Angulo; M. Partida-Pérez; J. Peregrina-Sandoval; R. Ramírez-Ramírez; R. Muñiz-Mendoza; S. Suárez-Villanueva; M. Centeno-Flores; V. Maciel-Gutiérrez; J.E. Cabrales-Vazquez; M.L. Ayala-Madrigal
03/31/2014
Breast cancer; Excision repair cross-complimentary group 1; Polymorphisms; susceptibility; Xeroderma pigmentosum complementation group F

Breast cancer is one of the most frequently diagnosed cancer in women worldwide, and we conducted a case-control study by genotyping seven potentially functional SNPs, three in ERCC1 and four in XPF, in a Chinese population of 417 breast cancer cases and 417 cancer-free controls. Three SNPs in ERCC1 and four SNPs in XPF were genotyped by using the Taqman Universal PCR Master Mix in the ... more

X.H. Pei; Z. Yang; X.Q. Lv; H.X. Li
03/24/2014
DLK2 gene; Growth and meat traits; Mutation; Polymorphisms; Qinchuan cattle

The delta-like 2 homolog (DLK2) modulates adipogenesis, hematopoiesis, osteogenesis, and other cell-differentiation processes. In the present study, we detected potential polymorphisms in the DLK2 gene in 604 individuals of Qinchuan cattle by using PCR-RFLP and DNA-sequencing methods. Herein, we identified five novel single-nucleotide polymorphisms (SNPs) (g.888G>A, g.910A> ... more

N. Yang; L.S. Zan; Y.K. Li; J.B. Gao; X.H. Ma; C.Z. Fu; H. Wang; C. Adoligbe
03/17/2014
Down syndrome; Folate; MTHFD; Polymorphisms; Transcobalamin gene

We examined whether polymorphisms in the methylenetetrahydrofolate dehydrogenase (MTHFD) and transcobalamin (TC) genes, which are involved in folate metabolism, affect maternal risk for Down syndrome. We investigated 76 Down syndrome mothers and 115 control mothers from Bengbu, China. Genomic DNA was isolated from the peripheral lymphocytes. Polymerase chain reaction and ... more

Y.P. Liao; D. Zhang; W. Zhou; F.M. Meng; M.S. Bao; P. Xiang; C.Q. Liu
02/28/2014
Asthma; IL-4; Meta-analysis; Polymorphisms; Promoter

This study aimed to more precisely assess the correlation between interleukin-4 (IL-4) promoter polymorphisms and the susceptibility risk of asthma. We conducted association studies on IL-4 promoter C-33T, C-589T, and G-1098T polymorphisms with asthma using data obtained from MEDLINE up to September 2011. Results showed that the polymorphisms IL-4 C-33T and C-589T were significantly ... more

L. Tang; H.G. Lin; B.F. Chen
06/12/2015
Chinese raccoon dog; Coat color; EDNRB gene; KIT gene; Polymorphisms

The Chinese raccoon dog (Nyctereutes procyonoides procyonoides) is one of the most important fur-bearing animal species. The dominant white individual, a coat color variant in farmed Chinese raccoon dog, shows a completely white phenotype over the entire body. The KIT and EDNRB genes have been reported to be associated with the dominant white coat color in some ... more

S.Q. Yan; C.Y. Bai; S.M. Qi; M.L. Li; S. Si; Y.M. Li; J.H. Sun
06/11/2015
Breast cancer; Ethnicity; Glutathione S-transferases; Northeastern Mexico; Polymorphisms

Glutathione S-transferases (GSTs) are a family of phase II metabolizing enzymes involved in carcinogen detoxification and the metabolism of various bioactive compounds. Several genes that code for these enzymes are polymorphic in an ethnicity-dependent manner, with particular genotypes previously associated with an increased risk of breast cancer. The purpose of this study was to ... more

G. Jaramillo-Rangel; M. Ortega-Martínez; R.M. Cerda-Flores; H.A. Barrera-Saldaña
06/12/2015
Molecular epidemiology; Osteoprotegerin; Polymorphisms; Rheumatoid arthritis

In order to investigate the association between osteoprotegerin (OPG) gene polymorphisms and rheumatoid arthritis (RA), we studied OPG rs3102735 T/C and rs2073618 G/C polymorphisms in a Chinese Han population comprising 574 patients with RA and 804 controls. Genotyping by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was conducted. Our data ... more

X.H. Ye; J.L. Cheng; R.P. Liu

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